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Autor:
Jamie M. Schwartz, Reem Almuqati, Sherrill D. Caprarola, Allen D. Everett, Megan K. Carroll, Ryan J. Felling, Aylin Tekes, Derek K. Ng, Melania M. Bembea, Cynthia F. Salorio
Publikováno v:
Pediatric Research. 92:549-556
BACKGROUND Inflammatory and endothelial activation responses during extracorporeal membrane oxygenation (ECMO) support in children are poorly understood. In this study, we aimed to determine if circulating inflammatory, endothelial activation, and fi
Autor:
Dean Huggard, Joanne Balfe, Lucas Lu Yoo, Fiona McGrane, Niamh Lagan, Edna Roche, Eleanor Gallagher, Amy Worrall, Eleanor J. Molloy, Lynne Kelly, Lida Fallah, Derek G. Doherty
Publikováno v:
Pediatric Research. 91:1812-1820
BackgroundDown syndrome (DS) is a disorder characterised by marked immune dysfunction, increased mortality from sepsis, chronic inflammation, increased oxidative stress, sleep disturbance and possibly abnormal endogenous melatonin levels. Melatonin h
Autor:
Jasmin Freeborn, Evelyn S. Park, J. Marc Rhoads, Stefan Roos, Venugopal Reddy Venna, Yuying Liu
Publikováno v:
Pediatric Research. 90:980-988
Background Probiotic Lactobacillus reuteri DSM 17938 (LR 17938) is beneficial to infants with colic. To understand its mechanism of action, we assessed ultrasonic vocalizations (USV) and brain pain/stress genes in newborn mice exposed to maternal sep
Autor:
Mark L. Hudak, Julia Harris, Joern Hendrik Weitkamp, Rajan Wadhawan, Jeanette M. Asselin, Cindy T. McEvoy, Dara G. Torgerson, Roberta A. Ballard, Philip L. Ballard, Cheryl J. Chapin
Publikováno v:
Pediatric Research
Background The pathogenesis of BPD includes inflammation and oxidative stress in the immature lung. Corticosteroids improve respiratory status and outcome, but the optimal treatment regimen for benefit with low systemic effects is uncertain. Methods
Publikováno v:
Pediatric Research
BackgroundNecrotizing enterocolitis (NEC) is the most common gastrointestinal disorder in premature neonates. Possible therapeutic approaches are centered on promoting maturation of the gastrointestinal mucosal barrier. Studies have demonstrated that
Autor:
Leenah Abugisisa, Erin L. Fee, Fabrizio Salomone, Noah H. Hillman, Gabrielle C. Musk, Emily Royse, Judith Rittenschober-Böhm, Matthew W. Kemp, Alan H. Jobe
Publikováno v:
Pediatric Research
Background Chorioamnionitis is associated with increased rates of bronchopulmonary dysplasia (BPD) in ventilated preterm infants. Budesonide when added to surfactant decreased lung and systemic inflammation from mechanical ventilation in preterm lamb
Autor:
Erin L. Fee, Leenah Abugisisa, Gabrielle C. Musk, Augusto F. Schmidt, Alan H. Jobe, Michael W. Clarke, Noah H. Hillman, Boris W. Kramer, Emily Royse, Matthew W. Kemp, Fabrizio Salomone
Publikováno v:
Pediatric research
Pediatric Research, 88(5), 726-732. Nature Publishing Group
Pediatric Research, 88(5), 726-732. Nature Publishing Group
Background: The addition of budesonide (Bud) 0.25 mg/kg to surfactant decreased the lung and systemic responses to mechanical ventilation in preterm sheep and the rates and severity of bronchopulmonary dysplasia (BPD) in preterm infants. We hypothesi
Autor:
Jelena Klawitter, Valerie Y. Chock, Uwe Christians, Adam Frymoyer, Krisa P. Van Meurs, David R. Drover
Publikováno v:
Pediatric research
BACKGROUND Theophylline, a non-selective adenosine receptor antagonist, improves renal perfusion in the setting of hypoxia-ischemia and may offer therapeutic benefit in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing hypothermia. We ev
Publikováno v:
Pediatric research
BACKGROUND Neonates with hypoxic-ischemic encephalopathy (HIE) frequently develop acute kidney injury (AKI). Aminophylline has been shown to reduce severe renal dysfunction in neonates after perinatal asphyxia. However, the effect of aminophylline on
Publikováno v:
Pediatric Research
Preterm infants are exposed to frequent painful procedures and agitating stimuli over the many weeks of their hospitalization in the neonatal intensive care unit (NICU). The adverse neurobiological impact of pain and stress in the preterm infant has