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Publikováno v:
Pediatric research
BACKGROUND Neonates with hypoxic-ischemic encephalopathy (HIE) frequently develop acute kidney injury (AKI). Aminophylline has been shown to reduce severe renal dysfunction in neonates after perinatal asphyxia. However, the effect of aminophylline on
Autor:
Marta Generoso, G. Marroncini, Iuri Corsini, Elena Gozzini, Cecilia Bresci, Simone Polvani, Carlo Dani, S. Tempesti, Tommaso Bianconi, Mirko Tarocchi, Andrea Galli
Publikováno v:
Pediatric Research. 81:364-368
Factors affecting innate immunity and acting as inflammatory regulators, such as the nuclear peroxisome proliferator-activated receptors (PPAR) could be crucial in the pathogenesis of necrotizing enterocolitis (NEC). We hypothesized that the PPARγ a
Publikováno v:
Pediatric research. 84(6)
Fetal erythropoietin (EPO), in addition to regulating erythropoiesis, has also tissue-protective properties based on its anti-inflammatory, anti-apoptotic, antioxidant, and neurotrophic effects. Notably, EPO concentrations needed for tissue protectio
Autor:
Luis Arruza, Nagat Mohammed, Natalia Escribano, Hector Lafuente, William H Hind, María Ruth Pazos, Francisco J. Alvarez-Diaz, Martín Santos, José Martínez-Orgado
Publikováno v:
Pediatric research. 82(1)
Brain hypoxic–ischemic (HI) damage induces distant inflammatory lung damage in newborn pigs. We aimed to investigate the effects of cannabidiol (CBD) on lung damage in this scenario. Newborn piglets received intravenous vehicle, CBD, or CBD+WAY1006
Publikováno v:
Pediatric Research
Background: Apnea associated with infection and inflammation is a major medical concern in preterm infants. Prostaglandin E2 (PGE2) serves as a critical mediator between infection and apnea. We hypothesize that alteration of the microsomal PGE syntha
Autor:
Adolf Valls-i-Soler, Heike Rabe, Carmen Rey-Santano, Juan M Lopez-de-Heredia, Victoria E. Mielgo
Publikováno v:
Pediatric research. 81(3)
Background: The aim of our study was to measure drug-related changes in hemodynamics and oxygen metabolism in response to different doses of an age-appropriate dobutamine formulation in hypoxic pigs. A secondary aim was to validate superior vena cava
Autor:
Thomas A. Churchill, Máximo Vento, David L. Bigam, Po-Yin Cheung, Namdar Manouchehri, Chloe Joynt
Publikováno v:
Pediatric research
INTRODUCTION There is little information regarding the comparative hemodynamic effects of adding milrinone or levosimendan to dopamine infusion in hypoxia-reoxygenated (H-R) newborns. RESULTS Severely hypoxic piglets had cardiogenic shock with depres
Publikováno v:
Pediatric Research. 69:378-383
Both the renin-angiotensin-aldosterone system (RAAS) and hypoxia are vital physiological factors involved in the control of nephrogenesis and vascularization. We investigated the relationship between RAAS and hypoxia in the developing kidney. The exp
Publikováno v:
Pediatric Research. 68:105-111
The mechanisms underlying the therapeutic function of caffeine on apneas in preterm neonates are not well determined. To better understand these effects, we exposed rat pups from postnatal d 3-12 to chronic intermittent hypoxia (5% O2/100 s every 10
Publikováno v:
Pediatric Research. 63:620-624
Preconditioning with hypoxia and hypoxia-mimetic compounds cobalt chloride (CoCl2) and desferrioxamine (DFX) protects against hypoxic-ischemic (HI) injury in neonatal rat brain. We examined long-term functional and protective actions of preconditioni