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Autor:
Arnaud Seigneurin, Jean Donadieu, Jean-François Emile, Mohamed Barkaoui, Franck Boralevi, A. Neron, Mathilde Tardieu, Islam Amine Larabi, Sophie Duvert-Lehembre
Publikováno v:
Pediatric Blood & Cancer. 68
BACKGROUND The somatic BRAFV600E mutation occurs in 38-64% of pediatric cases of Langerhans cell histiocytosis (LCH). Vemurafenib (VMF), a BRAF inhibitor, was approved for refractory BRAFV600E mutated LCH. In adults, VMF causes frequent cutaneous adv
Publikováno v:
Pediatric Blood & Cancer. 68
Objective Cytokine storms are central to the development of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH). Previous studies have shown that single-nucleotide polymorphisms (SNPs) of cytokine genes may be associated with t
Autor:
David A. Jacobsohn, Morris Kletzel, Jennifer Schneiderman, William T. Tse, Jenna Rossoff, Soyang Kwon, Sonali Chaudhury, Reggie E. Duerst
Publikováno v:
Pediatric Blood & Cancer. 68
Myeloablative conditioning regimens decrease the risk of relapse in pediatric patients undergoing allogeneic hematopoietic stem cell transplant (HCT) for hematologic malignancies, but cause significant toxicities PROCEDURE: This prospective study eva
Autor:
Alexandra J. Borst, Christopher M Bonfield, Chi H. Le, Jenna H. Sobey, Poornachanda S. Deenadayalan, Srijaya K Reddy, Meng Xu
Publikováno v:
Pediatric Blood & Cancer. 68
Complex cranial vault reconstruction (CCVR) for pediatric craniosynostosis is a high blood loss surgery, for which antifibrinolytic agents have been shown to reduce bleeding and transfusion requirements. The relative efficacy of ε-aminocaproic acid
Autor:
Qing Li, Vicky R. Breakey, Sumit Gupta, Jason D. Pole, Nicole Mittmann, Veda Zabih, Paul Gibson, Petros Pechlivanoglou, Mylene Bassal, Serina Patel, Uma H. Athale, Rinku Sutradhar, Mariana Silva
Publikováno v:
Pediatric Blood & Cancer. 68
BACKGROUND Therapy for childhood acute lymphoblastic leukemia (ALL) is associated with substantial health care utilization and burden on families. Little is known about health care utilization during specific treatment phases. PROCEDURES We identifie
Autor:
Brian T. Fisher, Lillian Sung, Ha Dang, Christopher C. Dvorak, Joel Thompson, Tammy Lo, Sarah Alexander
Publikováno v:
Pediatric Blood & Cancer. 68
Background Children receiving intensive chemotherapy for leukemia or undergoing hematopoietic stem cell transplant (HSCT) for solid tumors or leukemia are at risk for musculoskeletal (MSK) impairment from their underlying disease and from treatment.
Autor:
Kimikazu Matsumoto, Akimasa Yamatani, Motohiro Kato, Daisuke Tomizawa, Tomoo Osumi, Tomoyuki Utano, Kenichi Sakamoto, Kana Matsumoto
Publikováno v:
Pediatric Blood & Cancer. 68
Background Therapeutic drug monitoring for busulfan is important to prevent adverse events and improve outcomes in stem cell transplantation. We investigated intravenous busulfan pharmacokinetics and evaluated the utility of limited sampling strategy
Autor:
Fausto R. Loberiza, Andrew St. Martin, Wael Saber, Deborah Chirnomas, Christine Duncan, Patricia Steinert, Waleska S. Pérez, Caroline J. Hoang, Mei-Jie Zhang
Publikováno v:
Pediatr Blood Cancer
BACKGROUND: Gemtuzumab ozogamicin (GO) administered before allogeneic hematopoietic cell transplantation (alloHCT) has been linked to an increased risk of hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS). PROCEDURE: This retro
Autor:
Kelly E. Lake, Michael B. Jordan, Rebecca A. Marsh, Parinda A. Mehta, Adam Lane, Azada Ibrahimova, Vijaya Chaturvedi, Stella M. Davies, Erika Owsley, Kasiani C. Myers, Adam S. Nelson, Bridget Litts, Pooja Khandelwal
Publikováno v:
Pediatric Blood & Cancer. 68
Background We hypothesized that α4β7 integrin expression on effector memory T cells (TEMs) would be elevated in pediatric hematopoietic stem cell transplant (HSCT) patients before and at diagnosis of acute gastrointestinal graft-versus-host disease
Autor:
Cindy L. Schwartz, Andrea Lo, Tanja Pelz, Dirk Vordermark, Rita Engenhart-Cabillic, Kenneth B. Roberts, Louis S. Constine, Kara M. Kelly, Eve Gallop-Evans, David R. W. Hodgson, Karin Dieckmann
Publikováno v:
Pediatric Blood & Cancer. 68
Over the past century, classical Hodgkin lymphoma (HL) has been transformed from a uniformly fatal disease to one of the most curable cancers. Given the high cure rate, a major focus of classical HL management is reducing the use of radiation therapy