Zobrazeno 1 - 10
of 57
pro vyhledávání: ''
Autor:
Herbert Chen, Ronadip R. Banerjee, Deepti Dhall, Priyanka Gupta, Fabrice Viol, Rachael Guenter, M. Shahid Mukhtar, Frank Gillardon, Eugene A. Woltering, James A. Bibb, Angela M. Carter, Chunfeng Tan, John Totenhagen, Tyler R. McCaw, Hayden H Bickerton, Nilesh Kumar, J. Bart Rose, Elizabeth M. Kurian, Wayne Howse, Rahul Telange, Joerg Schrader, Sushanth Reddy, Brendon Herring
Publikováno v:
Oncogenesis, Vol 10, Iss 12, Pp 1-13 (2021)
Oncogenesis
Oncogenesis
Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous population of neoplasms that arise from hormone-secreting islet cells of the pancreas and have increased markedly in incidence over the past four decades. Non-functional PanNETs, which oc
Publikováno v:
Oncogenesis, Vol 10, Iss 11, Pp 1-12 (2021)
Oncogenesis
Oncogenesis
The role of Golgi/endosome-localized clathrin adapters in the maintenance of steady-state cell surface epidermal growth factor receptor (EGFR) is not well known. Here, we show that EGFR associates preferentially with both AP-1 and GGA2 in vitro. AP-1
Autor:
Cong Wang, Xintong Li, Kun Xu, Yongqian Shu, Fangyan Gao, Longfei Hu, Xiaoxiang Guan, Cenzhu Wang, Guohua Zhou, Hui Xie, Runtian Wang, Yiqiu Liu, Chengjun Zhu, Jiali Xu, Jinyi Huang, Wenbin Zhou
Publikováno v:
Oncogenesis, Vol 10, Iss 10, Pp 1-12 (2021)
Oncogenesis
Oncogenesis
Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single cells from 15 paired samples of primary tumors and axillary lymph nodes. We i
Autor:
Yang Sun, Hui-Nan Zhang, Wen Tian, Wei Cao, Xiao-Qiang Li, Shou-Jia Wang, Chen Ye, Yuan-Yuan Gao, Guang-Yuan Ma, Ying-Da Feng, Wen Ye
Publikováno v:
Oncogenesis, Vol 10, Iss 10, Pp 1-13 (2021)
Oncogenesis
Oncogenesis
Transient receptor potential canonical (TRPC) channels are the most prominent nonselective cation channels involved in various diseases. However, the function, clinical significance, and molecular mechanism of TRPCs in colorectal cancer (CRC) progres
Publikováno v:
Oncogenesis, Vol 10, Iss 9, Pp 1-12 (2021)
Oncogenesis
Oncogenesis
To understand the role of polyploid giant cancer cells (PGCCs) in drug resistance and disease relapse, we examined the mRNA expression profile of PGCCs following treatment with paclitaxel in ovarian cancer cells. An acute activation of IL-6 dominated
Publikováno v:
Oncogenesis, Vol 10, Iss 8, Pp 1-9 (2021)
Oncogenesis
Oncogenesis
Epidermal growth factor receptor (EGFR) remains the sole druggable molecular target other than the PD1/PD-L1 pathway with meaningful clinical benefit in squamous cell carcinoma of head and neck (SCCHN). Human epidermal growth factor receptor 3 (HER3)
Publikováno v:
Oncogenesis, Vol 10, Iss 7, Pp 1-14 (2021)
Oncogenesis
Oncogenesis
Ovarian cancer is the leading cause of gynecological malignancy-related deaths. Current therapies for ovarian cancer do not provide meaningful and sustainable clinical benefits, highlighting the need for new therapies. We show that the histone H3K79
Publikováno v:
Oncogenesis, Vol 10, Iss 7, Pp 1-12 (2021)
Oncogenesis
Oncogenesis
Interferon-inducible guanylate-binding proteins (GBPs) are well-known for mediating host-defense mechanisms against cellular pathogens. Emerging evidence suggests that GBPs are also implicated in tumorigenesis; however, their underlying molecular mec
Autor:
Xiaoya Duan, Wei Yang, Wencai Wang, Jiwen Li, Yuanyong Huang, Qihan Wu, Jiemin Wong, Jialun Li, Xiaoxing Chen, Jiwei Chen
Publikováno v:
Oncogenesis, Vol 10, Iss 5, Pp 1-15 (2021)
Oncogenesis
Oncogenesis
Global DNA hypomethylation is a most common epigenetic alteration in human neoplasia. However, accumulative evidence shows that global DNA hypomethylation impacts tumorigenesis in a tissue-specific manner, promoting tumorigenesis in some but suppress
Autor:
Tuyen Bui, Xiayu Rao, Natalie W. Fowlkes, Adel K. El-Naggar, Laurent Meijer, Jing Wang, Said Akli, Cansu Karakas, Khandan Keyomarsi, Amriti R. Lulla, Yoshitsugu Mitani, Kelly K. Hunt, Min Jin Ha
Publikováno v:
Oncogenesis, Vol 10, Iss 5, Pp 1-17 (2021)
Oncogenesis
Oncogenesis
Salivary gland cancers (SGCs) are rare yet aggressive malignancies with significant histological heterogeneity, which has made prediction of prognosis and development of targeted therapies challenging. In majority of patients, local recurrence and/or