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Autor:
Paul J.M. Roholl, Nicolas Collin, Harry van Dijken, Martin Friede, Paulo Lee Ho, José A Ferreira, Femke de Heij, Rineke de Jong, Eduardo Alfredo Adami, Sanne Spijkers, Milena Apetito Akamatsu, Justin Mouthaan, Willem Luytjes, Livia Brunner, Jørgen de Jonge
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-14 (2020)
npj Vaccines 5 (2020) 1
NPJ Vaccines
npj Vaccines, 5(1)
npj Vaccines 5 (2020) 1
NPJ Vaccines
npj Vaccines, 5(1)
Until universal influenza vaccines become available, pandemic preparedness should include developing classical vaccines against potential pandemic influenza subtypes. We here show that addition of SWE adjuvant, a squalene-in-water emulsion, to H7N9 s
Autor:
Q. David Walker, Cynthia M. Kuhn, Bruce E. Blough, Soman N. Abraham, Herman F. Staats, Hae Woong Choi, Ashley L. St. John
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-9 (2020)
NPJ Vaccines
NPJ Vaccines
Cocaine is one of the most potent and addictive psychostimulants known and there are no available pharmacotherapies to treat cocaine addiction. Here we describe a novel cocaine vaccine employing the mucosal adjuvant and mast cell-activating oligopept
Autor:
Do Jin Kim, Greta Van Slyke, Miles B. Brennan, Nicholas J. Mantis, Peter J. Didier, Neil Mlakar, Zachary A. Bornholdt, Ellen S. Vitetta, Dylan J. Ehrbar, Lioudmila Campbell, Kevin J. Whaley, Fernando J Torres-Velez, Chad J. Roy, Michelle Chen, Larry Zeitlin, Jeffrey W Froude, Lara A. Doyle-Meyers
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-8 (2020)
NPJ Vaccines
NPJ Vaccines
Inhalation of ricin toxin (RT), a Category B biothreat agent, provokes an acute respiratory distress syndrome marked by pro-inflammatory cytokine and chemokine production, neutrophilic exudate, and pulmonary edema. The severity of RT exposure is attr
Autor:
Kathleen A. Ross, Adel M. Talaat, Balaji Narasimhan, Yashdeep Phanse, Howard Steinberg, Chungyi Hansen, Akanksha Thukral
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-10 (2020)
NPJ Vaccines
NPJ Vaccines
Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) causes Johne’s disease in ruminants and is characterized by chronic gastroenteritis leading to heavy economic losses to the dairy industry worldwide. The currently available vaccine
Autor:
Anja Weinreich Olsen, Emma Lorenzen, Peter Andersen, Jes Dietrich, Malene Hvid, Nina Dieu Nhien Tran Nguyen, Frank Follmann
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-12 (2020)
NPJ Vaccines
Nguyen, N D N T, Olsen, A W, Lorenzen, E, Andersen, P, Hvid, M, Follmann, F & Dietrich, J 2020, ' Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge ', npj Vaccines, vol. 5, no. 1, 7 . https://doi.org/10.1038/s41541-020-0157-x
NPJ Vaccines
Nguyen, N D N T, Olsen, A W, Lorenzen, E, Andersen, P, Hvid, M, Follmann, F & Dietrich, J 2020, ' Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge ', npj Vaccines, vol. 5, no. 1, 7 . https://doi.org/10.1038/s41541-020-0157-x
The optimal protective immunity against Chlamydia trachomatis (C.t.) is still not fully resolved. One of the unresolved issues concerns the importance of resident immunity, since a recent study showed that optimal protection against a transcervical (
Autor:
Germain J. P. Fernando, Hwee-Ing Ng, Mark A. F. Kendall, Zewen K. Tuong, Stefano C. Meliga, Ian H. Frazer, Alexandra C. I. Depelsenaire
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-12 (2019)
NPJ Vaccines
NPJ Vaccines
Chemical adjuvants are typically used to improve immune responses induced by immunisation with protein antigens. Here we demonstrate an approach to enhance immune responses that does not require chemical adjuvants. We applied microprojection arrays t
Autor:
Soiba Khalid Mansoor, Laurel O. Sillerud, Judy L. Cannon, David S. Peabody, Fadi A. Jamaleddin Ahmad, Jonathan L. Brigman, Erin Crossey, Kiran Bhaskar, Yirong Yang, Amanda Yaney, Julianne Peabody, Bryce Chackerian, Colin M. Wilson, Maria Alvarez, Nicole Maphis, Shanya Jiang, Reed Selwyn
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-13 (2019)
NPJ Vaccines
NPJ Vaccines
Tauopathies, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are progressive neurodegenerative diseases clinically characterized by cognitive decline and could be caused by the aggregation of hyperphosphorylated pathological ta
Autor:
Charles A. Scanga, Mario Roederer, JoAnne L. Flynn, Mark Rodgers, Pauline Maiello, Joshua A Hackney, Thomas Lindenstrøm, Amy J. Myers, Victor Prikhodko, Dominick Laddy, Hannah P. Gideon, Patricia A. Darrah, Philana Ling Lin, Robert M. DiFazio, Peter Andersen, Thomas J. Evans, Robert A. Seder
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-13 (2019)
NPJ Vaccines
NPJ Vaccines
Tuberculosis (TB) is the leading cause of death from infection worldwide. The only approved vaccine, BCG, has variable protective efficacy against pulmonary TB, the transmissible form of the disease. Therefore, improving this efficacy is an urgent pr
Autor:
Rhea N. Coler, Tracey A. Day, Ruth Ellis, Franco M. Piazza, Anna Marie Beckmann, Julie Vergara, Tom Rolf, Lenette Lu, Galit Alter, David Hokey, Lakshmi Jayashankar, Robert Walker, Margaret Ann Snowden, Tom Evans, Ann Ginsberg, Steven G. Reed, The TBVPX-113 Study Team
Publikováno v:
npj Vaccines, Vol 3, Iss 1, Pp 1-9 (2018)
NPJ Vaccines
NPJ Vaccines
Tuberculosis (TB) is the leading cause of infectious death worldwide. Development of improved TB vaccines that boost or replace BCG is a major global health goal. ID93 + GLA-SE is a fusion protein TB vaccine candidate combined with the Toll-like Rece
Publikováno v:
npj Vaccines, Vol 3, Iss 1, Pp 1-9 (2018)
NPJ Vaccines
NPJ Vaccines
With increasing age, as the incidence of Alzheimer’s disease is increasing, finding a therapeutic intervention is becoming critically important to either prevent or slow down the progression of the disease. Passive immunotherapy has been demonstrat