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Autor:
Kathy B. Baumgartner, Stephanie D. Boone, Yunfeng Cao, Avonne E. Connor, Kala Visvanathan, Richard N. Baumgartner
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-8 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Physical activity is recommended for most cancer patients as a nonpharmacological therapy to improve prognosis. Few studies have investigated the association between physical activity and breast cancer prognosis by ethnicity, biological, and modifiab
Autor:
Lixi Li, Jingtong Zhai, Xiuwen Guan, Haili Qian, Hui Li, Quchang Ouyang, Jin Li, Binliang Liu, Fei Ma, Binghe Xu, Chunxiao Li, Yanfang Guan, Guohua Rong, Ling Yang, Zongbi Yi, Wenna Wang, Xin Yi, Chang Lianpeng, Xuefeng Xia, Lifeng Li
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-8 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Human epidermal growth factor receptor 2 (HER2) protein overexpression or gene amplification is an important predictive biomarker for identifying patients with breast cancer, who may benefit from HER2-targeted therapy. However, little is known about
Autor:
Sarat Chandarlapaty, Hong Zhang, Fresia Pareja, Jorge S. Reis-Filho, Pier Selenica, Lorenzo Ferrando, Britta Weigelt, Amir Farmanbar, Gabriele Zoppoli, Pedram Razavi, Simon S K Lee, Hannah Y Wen, Edi Brogi, David N Brown, Mark E. Robson, Francisco Beca, Mahsa Vahdatinia, Arnaud Da Cruz Paula
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-10 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Histologic special types of breast cancer (BC) account for ~20% of BCs. Large sequencing studies of metastatic BC have focused on invasive ductal carcinomas of no special type (IDC-NSTs). We sought to define the repertoire of somatic genetic alterati
Autor:
Regina Barragan-Carrillo, Ana S. Ferrigno, Cynthia De la Garza-Ramos, Hatem A. Azim, Cynthia Villarreal-Garza, Matteo Lambertini
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-9 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Risk stratification by genomic signatures has been shown to improve prognostication and guide treatment decisions among patients with hormone-sensitive breast cancer. However, their role in young women has not been fully elucidated. In this review, a
Autor:
Xiang Zhang, Guo Chao Zhong, Guosheng Ren, Zhu Yue Li, Qing Li, Yang Shi, Tingxiu Xiang, James R. Hébert, Kang Wang, Theodoros Foukakis, Hong Yuan Li, Jia Zheng Sun, Nitin Shivappa, Jiali Zheng, Da Xue Li, Qian Xue Wu, Yong Fu Xiong
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-11 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Inflammation-modulating nutrients and inflammatory markers are established cancer risk factors, however, evidence regarding the association between post-diagnosis diet-associated inflammation and breast cancer survival is relatively sparse. We aimed
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-12 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Recurrence of estrogen receptor (ER)-positive breast tumors despite curative-intent adjuvant therapy is thought to be due to enrichment of tumor initiating cells (TIC) during endocrine therapy (ET). Recently, it was identified that by antagonizing th
Autor:
Athina Kostara, Hakima Harrach, Mattea Reinisch, Mark H Dyson, Rita K. Schmutzler, Ouafaa Chiari, Sherko Kuemmel, Katja Ziegler-Löhr
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-4 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
There is a strong biologic rationale that poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors may benefit a broader range of metastatic breast cancer (MBC) patients than covered by current approvals, which require a germline BRCA1/2 seque
Autor:
Brian M. Alexander, Miriam J. Haviland, Nadine Tung, Judy Garber, Edward T. Richardson, Laura C. Collins, Vanda F. Torous, Jaymin M. Patel, Gordon J. Freeman, Michele R. Hacker, Stuart J. Schnitt, Andrew J. Goss, Tessa Nalven, Larissa J. Lee
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-6 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Retinoblastoma protein (Rb) is a product of the RB tumor suppressor gene. Its expression is highly prevalent in luminal breast cancers and is critical to the success of cyclin-dependent kinase (CDK) 4/6 inhibitor therapy. Expression of Rb in triple-n
Autor:
Andrew R. Green, David L Goode, Simone M Rowley, Jia-Min Pang, Kylie L. Gorringe, Ian G. Campbell, Tanjina Kader, Dane Cheasley, Emad A. Rakha, Prue Hill, G. Bruce Mann, Kenneth Elder, Niko Thio, Stephen B. Fox, David J Byrne, Timothy Semple, Islam M. Miligy, Magnus Zethoven
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-13 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Intraductal papillomas (IDP) are challenging breast findings because of their variable risk of progression to malignancy. The molecular events driving IDP development and genomic features of malignant progression are poorly understood. In this study,
Autor:
Michael Vallis, Som D. Mukherjee, Kathleen I. Pritchard, Roanne J. Segal, B. Findlay, André Robidoux, Pamela J. Goodwin, Gregory R. Pond, Mark Levine, Julie R. Gralow, Jennifer A. Ligibel
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-7 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Obesity has been associated with poor breast cancer (BC) outcomes. We investigated whether a standardized, telephone-based weight loss lifestyle intervention in the adjuvant setting would impact BC outcomes. We conducted a multicenter trial randomizi