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Autor:
Hiroyuki Sasaki, Aya Muto, Yu Tahara, Takuya Shiraishi, Atsushi Haraguchi, Shigenobu Shibata, Mayu Yamazaki, Yosuke Kikuchi, Yuta Takatsu, Takahiro Nakamura, Hiroaki Motohashi, Daisuke Kuriki
Publikováno v:
NPJ Aging and Mechanisms of Disease
The ability of the circadian clock to adapt to environmental changes is critical for maintaining homeostasis, preventing disease, and limiting the detrimental effects of aging. To date, little is known about age-related changes in the entrainment of
Autor:
Matthias P. Mayer, Robert A. Knieß
Publikováno v:
NPJ Aging and Mechanisms of Disease
What is cause and what is consequence of aging and whether reactive oxygen species (ROS) contribute to this phenomenon is debated since more than 50 years. Notwithstanding, little is known about the cellular buffer and redox systems in aging Saccharo
Publikováno v:
NPJ Aging and Mechanisms of Disease
Different cell types within the body exhibit substantial variation in the average time they live, ranging from days to the lifetime of the organism. The underlying mechanisms governing the diverse lifespan of different cell types are not well underst
Autor:
Alejandro Martin-Montalvo, Kevin J. Pearson, Annie X Wang, Kenneth W. Fishbein, Ahmed Ali, Morten Scheibye-Knudsen, Julia Ariza, Jessica Curtis, Michel Bernier, Alberto Diaz-Ruiz, Emilio Siendones, Xianlin Han, José M. Villalba, Howard G. Shertzer, Rafael de Cabo, Richard G. Spencer, Plácido Navas, Joe A Baur, Gelareh Abulwerdi, Yaning Sun, Xiaoping Sun, Vincent M. Gutierrez, Sige Zou, Hector H. Palacios, Miao Wang
Publikováno v:
NPJ Aging and Mechanisms of Disease
Cytochrome b5 reductases (CYB5R) are required for the elongation and desaturation of fatty acids, cholesterol synthesis and mono-oxygenation of cytochrome P450 enzymes, all of which are associated with protection against metabolic disorders. However,