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Autor:
Jouji Horiuchi, Yu Sato
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 115(6)
In this study, we investigated the hypothesis that mexiletine has an inhibitory action on spontaneous sensory afferent activity caused by small fiber neuropathy in diabetic rats (WBN/Kob rats). Gastric administrations of mexiletine (10 mg in 0.3 ml s
Autor:
Osamu YAOKA, Kazumi AOKI, Tsuneyo YAMADA, Tohru NAKAJIMA, Michihide SETOGUCHI, Ikurou NAKAMURA, Kiyoteru IKEGAMI, Yuuji TOMITAKA, Kyoryu OKUDA, Hiroshi HORIZOE, Tadao NAKAMURA, Yutaka MARUYAMA
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 102(5)
The effects of repeated administration of quinapril (10 mg/kg/day) on the development of hypertension, cardiac hypertrophy and survival rate were examined, and compared with those of enalapril (10 mg/kg) in salt-sensitive Dahl (Dahl S) rats and 1% sa
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 100(4)
To clarify the therapeutic effects of several traditional Chinese medicines to improve disorders of carbohydrate, lipid and mineral metabolism, spontaneously diabetic rats (WBN/Kob) were treated with Vit. D2, 1 x 10(5) I.U./kg b.w./day, for 4 days, a
Autor:
Koichi Seto, Kyoji Chaki, Eijiro Tagashira, Yuko Hori, Tomoyuki Yoneta, Hitoshi Morita, Hiroko Yamada, Toshihiko Takemasa, Masao Seiki, Hiroyuki Aita
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 99(5)
We studied the healing promoting action of Z-103 on the chronic gastric ulcer induced by acetic acid (AAU) or Fe-ascorbic acid (FAU) in rats. The area of the gastric ulcers, hydroxyproline (Hyp) and DNA contents in the ulcer region were measured as a
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 99(4)
In mice, SNB-5001 released reticulocytes dose-dependently. In rats, rabbits and dogs given the same doses of SNB-5001, each dose-response curve of hemopoiesis almost showed parallelism. SNB-5001 induced nearly the same extent of hemopoiesis in these
Autor:
Seiji Toyama, Shigeru Furuta, Yuko Hori, Hitoshi Morita, Masao Seiki, Yukinori Mera, Eijiro Tagashira, Tomoyuki Yoneta, Kaneyasu Arai, Hiroyuki Aita
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 99(4)
The gastric mucosal adhesiveness of Z-103 in rats with acetic acid ulcer was studied macroscopically, histologically, and biochemically. From macroscopical observations, when Z-103 was orally administered to an acetic acid ulcer model, there was adhe
Autor:
Tohru Natsuga, Takayuki Sugiyama
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 98(4)
The effects of low molecular weight heparin (LHG) on the blood coagulation system, hemorrhage, lipolytic activity and bone metabolism were compared with those of conventional sodium heparin (Heparin). The anti-thrombin activity of LHG measured by the
Autor:
K, Kamiyasu, H, Awata, S, Inoshiri, A, Doi, N, Omawari, T, Okegawa, A, Kawasaki, K, Shinomiya, M, Tanaka, Y, Suzuki
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 97(5)
We investigated the effect of camostat mesilate (FOY-305), an oral protease inhibitor, on reflux esophagitis after total gastrectomy followed by an end-to-side esophago-jejunostomy (Billroth-II) in rats. Effects of FOY-305 were compared with those of
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 97(3)
Amlodipine (AML), a new 1,4-dihydropyridine derivative, similar to nifedipine (NIF), dose-dependently relaxed or inhibited the KCL-contraction (cont.) of dog coronary artery (DCA) and rat aorta (RA) and the spontaneous motility of rat portal vein (RP
Autor:
Seiichiro Mochizuki, Shuichi Wakabayashi, Hitomi Sekiguchi, Makoto Matsumoto, Masaya Takeuchi, Koji Takeuchi, Susumu Okabe, Akira Tomiyama, Kazuhiro Kosakai
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 97(2)
We examined the healing promoting effects of azuletil sodium on acetic acid and clamping cortisone-induced gastric ulcer in rats. For the experiments on clamping-cortisone gastric ulcer, we used not only conventional rats in conventional conditions b