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Autor:
Alla Mitrofanova, Jacopo Sgrignani, Judith Molina, Andrea Cavalli, Mengyuan Ge, Cyrille Maugeais, Alexis Sloan, Marco Prunotto, Laura Barisoni, G. Michelle Ducasa, Matthew Blake Wright, Christian Kemmer, Christopher E. Pedigo, Anis Ahmad, Javier Varona Santos, Stephan Roever, Jeffrey Pressly, Alessia Fornoni, Armando J. Mendez, Sandra Merscher, Jean-Philippe Carralot
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Impaired cellular cholesterol efflux is a key factor in the progression of renal, cardiovascular, and autoimmune diseases. Here we describe a class of 5-arylnicotinamide compounds, identified through phenotypic drug discovery, that upregulate ABCA1-d
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Kinship networks are a fundamental social unit in human societies, and like social networks in general, provide social support in times of need. Here, we investigate the impact of sudden environmental shock, the Ms 7.0 2013 Ya’an earthquake, on the
Autor:
Rachit Badolia, Salah Sommakia, Aishwarya Aravamudhan, Aspasia Thodou Krokidi, Dipayan Chaudhuri, Thomas Gudermann, Paulina Sander, Kira Steinhorst, Ohyun Kwon, Stavros G. Drakos, Dinesh K. A. Ramadurai, Kenneth W. Spitzer, Sutip Navankasattusas, Andreas Dendorfer, Frank B. Sachse, Jing Ling, Emily H. Cheng, Thirupura S. Shankar, Johann Schredelseker, Dallen Calder, Kevin J. Whitehead, Changmin Xie, Oh Sung Kwon, Russel S. Richardson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin known to play a significant role in apoptosis and calcium signaling. Abnormalities in calcium homeostasis often leads to electrical and contractile dysfunction and can
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal cell development and motility. Aberrant activation of c-MET can lead to both tumors growth and metastatic progression of cancer cells. C-MET can be activated
Autor:
Liqin Xu, Jia Fan, Yu Zhong, Miaomiao Jiang, Xiao-Rui Zhou, Yong Hou, Geng Liu, Min Du, Guibo Li, Shuang-Jian Qiu, Yuan Ji, Sun Yunfan, Xiangdong Wang, Bo Hu, Ashley R. Dennison, Sheng Liu, Ze-Fan Zhang, Qichao Yu, Xiaoyun Huang, Yang Xu, Ying-Hong Shi, David H. Peng, Wen-Yuan Chung, Kai-Qian Zhou, Nannan Li, Wei Guo, Liang Wu, Jian Zhou, Xin-Rong Yang, Hui-Chuan Sun, Michael Dean, Shiping Liu, Zhikun Zhao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the transcriptome of 113 single CTCs from 4 different vascular sites, including hepa
Autor:
James M. Dolezal, Lara R. Heij, Jefree J. Schulte, Dezheng Huo, Olufunmilayo I. Olopade, Robert L. Grossman, Heather Chen, Nicole A. Cipriani, Frederick M Howard, Sara Kochanny, Jakob Nikolas Kather, Rita Nanda, Alexander T. Pearson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications 12(1), 4423 (2021). doi:10.1038/s41467-021-24698-1
Nature Communications
Nature Communications 12(1), 4423 (2021). doi:10.1038/s41467-021-24698-1
The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital histology. Deep learning (DL) models have been trained on TCGA to predict numerous features directly from histology, including survival, gene expression patterns, and dri
Autor:
Harvey J. Kliman, Lorena Benedetti, Zhonghua Tang, Tzumin Lee, Isabel Espinosa-Medina, Jennifer Lippincott-Schwartz, Kristin M. Milano, Seth Guller, Aubrey V. Weigel, Carolyn Ott, Daniel Feliciano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Cells in many tissues, such as bone, muscle, and placenta, fuse into syncytia to acquire new functions and transcriptional programs. While it is known that fused cells are specialized, it is unclear whether cell-fusion itself contributes to programma
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Stimulator of interferon genes (STING) promotes anti-tumour immunity by linking innate and adaptive immunity, but it remains unclear how intratumoural treatment with STING agonists yields anti-tumour effects. Here we demonstrate that intratumoural in
Autor:
Bing Su, Yalan Chen, Zi Liang, Quan Zheng, Rong Cai, Jianmin Gu, Qi Wang, Wen Yang, Qiuju Fan, Gaolei Hu, Y. Eugene Chin, Jiao Ma, Ying Cao, Liufu Deng, Yitao Qi, Guo-Qiang Chen, Tianshi Wang, Wei Zhou, Yong Zuo, Jun Tu, Wei Xue, Xun Shangguan, Cen Jiang, Shengdian Wang, Jinke Cheng, Hongsheng Tan, Baijun Dong, Jianli He
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Metabolic programming and mitochondrial dynamics along with T cell differentiation affect T cell fate and memory development; however, how to control metabolic reprogramming and mitochondrial dynamics in T cell memory development is unclear. Here, we
Autor:
Jason Y. K. Chan, Vivian Wai Yan Lui, Sau Dan Lee, Trevor J. Pugh, Brigette B.Y. Ma, Yvonne Y. Y. Or, Kwok Wai Lo, Lee Fah Yap, Yuk-Yu Chan, Edwin P. Hui, Fei-Fei Liu, Yuchen Liu, Michael K. F. Mak, Chit Chow, Pui Kei Siu, Anthony T.C. Chan, Samah El Ghamrasni, Chi Man Tsang, Grace Tin-Yun Chung, Johnny S. H. Kwan, Ian C. Paterson, Jeff Bruce, Man Wu, C. Andrew van Hasselt, Kevin Y. Yip, Christopher W. Dawson, Sai Wah Tsao, John K. S. Woo, Sharmila Velapasamy, Ka Fai To, Lawrence S. Young, Stephenie Prokopec
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Interplay between EBV infection and acquired genetic alterations during nasopharyngeal carcinoma (NPC) development remains vague. Here we report a comprehensive genomic analysis of 70 NPCs, combining whole-genome sequencing (WGS) of microdissected tu