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Autor:
Darren H. Freed, M. Buchko, Kieran Halloran, A. Hirji, Jeffrey C. Cheng, Jayan Nagendran, Nasim Boroumand
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
Nature Communications
Nature Communications
Lung transplantation remains the best treatment option for end-stage lung disease; however, is limited by a shortage of donor grafts. Ex situ lung perfusion, also known as ex vivo lung perfusion, has been shown to allow for the safe evaluation and re
Autor:
Jun Yong Lee, David J. Mooney, Bo Ri Seo, David M. Wu, Catia S. Verbeke, Miguel C. Sobral, Hua Wang, Aileen Weiwei Li, Alexander J. Najibi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Poorly immunogenic tumors, including triple negative breast cancers (TNBCs), remain resistant to current immunotherapies, due in part to the difficulty of reprogramming the highly immunosuppressive tumor microenvironment (TME). Here we show that peri
Autor:
Wei-Yu Chen, Ming-Shi Chang, Shao Wei Lu, Kung Chao Chang, Yu Hsiang Hsu, Li Wha Wu, Hong Chin Pan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Pancreatic ductal adenocarcinoma (PDAC) and cancer-associated cachexia (CAC) are multifactorial and characterized by dysregulated inflammatory networks. Whether the proinflammatory cytokine IL-20 is involved in the complex networks of PDAC and CAC re
Autor:
Luke F Fritzky, Qing Yi, Hsiang chi Tseng, Jie gen Jiang, James V. Guarrera, Wei-Xing Zong, Ting Liu, Minh Ma, Wei Xiong, Yan Yang, Dongfang Liu, Saiaditya Badeti, Gianpietro Dotti, Carlos A. Ramos, Chen Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Chimeric antigen receptor (CAR) therapy is a promising immunotherapeutic strategy for treating multiple refractory blood cancers, but further advances are required for solid tumor CAR therapy. One challenge is identifying a safe and effective tumor a
Autor:
Zhaoyang Li, Zhenduo Cui, Yong Han, Kelvin W.K. Yeung, Yufeng Zheng, Changyi Li, Yuqian Qiao, Xiangmei Liu, Yanqin Liang, Xianbao Wang, Shuilin Wu, Shengli Zhu, Bo Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomy
Autor:
Guoxiang Cai, Zhenyu Liu, Jie Tian, Jiangang Liu, Xiaochun Meng, Peiyi Xie, Hongmei Zhang, Yingying Ding, Kai Sun, Meiyun Wang, Yankai Meng, Weixing Dai, Zhenhui Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Distant metastasis (DM) is the main cause of treatment failure in locally advanced rectal cancer. Adjuvant chemotherapy is usually used for distant control. However, not all patients can benefit from adjuvant chemotherapy, and particularly, some pati
Autor:
Robert W. Cross, Abhishek N. Prasad, Zachary A. Bornholdt, Joan B. Geisbert, Krystle N. Agans, Daniel J. Deer, Viktoriya Borisevich, Larry Zeitlin, Armand Sprecher, Thomas W. Geisbert, Heinz Feldmann, Karla A. Fenton, Kevin Melody
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications
Nature Communications
A replication-competent vesicular stomatitis virus vaccine expressing the Ebola virus (EBOV) glycoprotein (GP) (rVSV-ZEBOV) was successfully used during the 2013-16 EBOV epidemic. Additionally, chimeric and human monoclonal antibodies (mAb) against t
Autor:
Li Chen, Robert N. Cooney, Matthew Dai, Lili Wang, Juntao Luo, Qinghe Meng, Dandan Guo, Changying Shi, Guirong Wang, Xiaojing Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Targeting single mediators has failed to reduce the mortality of sepsis. We developed a telodendrimer (TD) nanotrap (NT) to capture various biomolecules via multivalent, hybrid and synergistic interactions. Here, we report that the immobilization of
Autor:
Sylvain Provot, Hervé Acloque, Yetki Aslan, William Taylor, Charlotte Auriau, Eva Hadadi, Marthe Villote, Gaelle Duvallet, Xiao-Mei Li, Julie Rivière, Annelise Bennaceur-Griscelli, Isabelle Raymond-Letron, Sandrine Dulong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.3193. ⟨10.1038/s41467-020-16890-6⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3193. ⟨10.1038/s41467-020-16890-6⟩
Nature Communications
Nature Communications, 2020, 11 (1), pp.3193. ⟨10.1038/s41467-020-16890-6⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3193. ⟨10.1038/s41467-020-16890-6⟩
Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption m
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Chronic pancreatitis represents a risk factor for the development of pancreatic cancer. We find that heterozygous loss of histone H2A lysine 119 deubiquitinase BAP1 (BRCA1 Associated Protein-1) associates with a history of chronic pancreatitis and oc