Zobrazeno 1 - 10
of 100
pro vyhledávání: ''
Autor:
Melissa Cadena, Erkki Ruoslahti, Robert Doherty, Padma Kadiyala, Maria G. Castro, Samer Habeel, Joerg Lahann, Jason V. Gregory, Pedro R. Lowenstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Glioblastoma (GBM), the most aggressive form of brain cancer, has witnessed very little clinical progress over the last decades, in part, due to the absence of effective drug delivery strategies. Intravenous injection is the least invasive drug deliv
Autor:
Xuejiang Gu, Xinjie Zhao, Shenghan Lai, Guixue Hou, Yixuan Qiu, Huanzi Zhong, Ping Kong, Huahui Ren, Jialin Yang, Yongde Peng, Shan Huang, Zhun Shi, Yanyun Gu, Guowang Xu, Guang Ning, Shen Qu, Junhua Li, Yifei Zhang, Li Chen, Qin Huang, Yaoming Xue, Li Qin, Xiaolin Wang, Qi Li, Mengyu Gao, Jing Ma, Li Xuelin, Gang Chen, Huanming Yang, Weiqing Wang, Shujie Wang, Yuanqiang Zou, Jian Wang, Jun Liang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering gut microbiota like oral intake of probiotics or berberine (BBR), a bacteriostatic agent, merit metabolic homoeostasis. We hence conducted a randomized,
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
Harmful effects of high fructose intake on health have been widely reported. Although fructose is known to promote cancer, little is known about the underlying mechanisms. Here, we found that fructose triggers breast cancer metastasis through the ket
Autor:
Peter Abbink, Jinyan Liu, Mish Michael R, Po-Ting Liu, Noe B. Mercado, Dan H. Barouch, Joseph Hesselgesser, Elena Bekerman, Erica N. Borducchi, Brandon F. Keele, Abishek Chandrashekar, Gregory Chin, Esther A. Bondzie, Romas Geleziunas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Viral rebound following antiretroviral therapy (ART) discontinuation in HIV-1-infected individuals is believed to originate from a small pool of CD4+ T cells harboring replication-competent provirus. However, the origin and nature of the rebound viru
Autor:
Tobias Junt, Gieri Cathomas, Kirsten D. Mertz, Viktor H. Koelzer, Holger Moch, Francesca Demichelis, Thomas Hoyler, Alexandar Tzankov, Nathalie Schwab, Niels Willi, Maurice Henkel, Werner Kempf, Angela Frank, Ronny Nienhold, Thomas Menter, Markus Tolnay, Veronika Zsikla, Mattia Barbareschi, Jasmin D. Haslbauer, Yari Ciani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has been proposed as a patho
Autor:
Larissa M. N. Pereira, Katherine A. Fitzgerald, Caroline Junqueira, Patricia A. Assis, Ricardo T. Gazzinelli, Dario S. Zamboni, Dhelio Batista Pereira, Natalia M. de Araujo, Danielle Fernandes Durso, Egil Lien, Douglas T. Golenbock, Marco Antonio Ataide
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications
Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a central mediator of systemic inflammation, septic shock in the Pl
Autor:
Liu Xiaolin, Nanshan Zhong, Jia Wu, Fan Zhang, Xuefeng Niu, Chufang Li, Yichu Liu, Jia Luo, Xinglong Liu, Ying Feng, Jincun Zhao, Peiyu Hu, Chenchen Yang, Guan Suhua, Ren-Di Jiang, Xinwen Chen, Ling Chen, Zhiming Yuan, Xuehua Zheng, Qian Wang, Yingying Gu, Chao Shan, Liqiang Feng, Yiwu Zhou, Jing Sun, Yongcun Xu, Changwen Ke, Tao Xu, Weiqi Pan, Bo Liu, Pingchao Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
The rapid spread of coronavirus SARS-CoV-2 greatly threatens global public health but no prophylactic vaccine is available. Here, we report the generation of a replication-incompetent recombinant serotype 5 adenovirus, Ad5-S-nb2, carrying a codon-opt
Autor:
Charlotte Hansen, Marcus Altfeld, Claudia Marggraff, Jill Noll, Stefan Hoenow, Iris Bruchhaus, Nahla Galal Metwally, Marie Weskamm, Marie Groneberg, Christoph Dorn, Stephanie Stanelle-Bertram, Svenja Kuehl, Harald Ittrich, Thomas Jacobs, Sven Hendrik Hagen, Julie Sellau, Egbert Tannich, Julia Wernecke, Vincent Wolf, Helena Fehling, Thorsten Thye, Hannelore Lotter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Hepatic amebiasis, predominantly occurring in men, is a focal destruction of the liver due to the invading protozoan Entamoeba histolytica. Classical monocytes as well as testosterone are identified to have important functions for the development of
Autor:
Peiqiang Su, Chunyu Li, Xilin Liu, Gene Elliott, Zhuo Zhao, Yingzi Yang, Alejandro A. Schäffer, Yueshu Wang, Nga Ting Choi, Cheng Wang, Danny Chan, Lisa Garrett, Yufa Wang, Bo Gao, Jin Wang, Ni Wang, Shusen Cui
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Carpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment syndrome, affecting a large proportion of the general population. Genetic susceptibility has been implicated in CTS, but the causative genes remain elusive. Here, we report t
Autor:
Robert W. Cross, Abhishek N. Prasad, Zachary A. Bornholdt, Joan B. Geisbert, Krystle N. Agans, Daniel J. Deer, Viktoriya Borisevich, Larry Zeitlin, Armand Sprecher, Thomas W. Geisbert, Heinz Feldmann, Karla A. Fenton, Kevin Melody
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications
Nature Communications
A replication-competent vesicular stomatitis virus vaccine expressing the Ebola virus (EBOV) glycoprotein (GP) (rVSV-ZEBOV) was successfully used during the 2013-16 EBOV epidemic. Additionally, chimeric and human monoclonal antibodies (mAb) against t