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Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Diagnostic histopathology is a gold standard for diagnosing hematopoietic malignancies. Pathologic diagnosis requires labor-intensive reading of a large number of tissue slides with high diagnostic accuracy equal or close to 100 percent to guide trea
Autor:
Nikunj Sharma, David R Sweet, Panjamaporn Sangwung, Yoichi Takami, Neelakantan T Vasudevan, Anthony Wynshaw-Boris, Paul Holvoet, Yuan Lu, Liyan Fan, Xudong Liao, Stanton L. Gerson, E. Ricky Chan, Chen Fu, Chloe E Booth, Vinesh Vinayachandran, Guangjin Zhou, Lilei Zhang, Keiichiro Matoba, Yulan Qing, Komal S Keerthy, Mukesh K. Jain, Lalitha Nayak, Derin Tugal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Substantial evidence implicates crosstalk between metabolic tissues and the immune system in the inception and progression of obesity. However, molecular regulators that orchestrate metaflammation both centrally and peripherally remains incompletely
Autor:
Michael F. Press, Ali Madani, Nitish Shirish Keskar, David B. Agus, Daniel Ruderman, Nikhil Naik, Richard Socher, Andre Esteva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications
Nature Communications
For newly diagnosed breast cancer, estrogen receptor status (ERS) is a key molecular marker used for prognosis and treatment decisions. During clinical management, ERS is determined by pathologists from immunohistochemistry (IHC) staining of biopsied
Autor:
Melissa Cadena, Erkki Ruoslahti, Robert Doherty, Padma Kadiyala, Maria G. Castro, Samer Habeel, Joerg Lahann, Jason V. Gregory, Pedro R. Lowenstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Glioblastoma (GBM), the most aggressive form of brain cancer, has witnessed very little clinical progress over the last decades, in part, due to the absence of effective drug delivery strategies. Intravenous injection is the least invasive drug deliv
Autor:
R. Stephanie Huang, Alexander Ling
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Evidence has recently emerged that many clinical cancer drug combinations may derive their efficacy from independent drug action (IDA), where patients only receive benefit from the single most effective drug in a drug combination. Here we present IDA
Autor:
Fenghua Zhang, Yingcai Wang, Boning Zhang, Hanan S. Haymour, Xin Liu, Madduri Srinivasarao, Philip S. Low, Le Cun Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Seasonal influenza epidemics lead to 3–5 million severe infections and 290,000–650,000 annual global deaths. With deaths from the 1918 influenza pandemic estimated at >50,000,000 and future pandemics anticipated, the need for a potent influenza t
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer
Autor:
Liang Jin, Zijie Cai, Hongna Lai, Ying Li, Zongqi Wu, Erwei Song, Yujie Liu, Jingru Wang, Qiang Liu, Yudong Li, Mengdi Zhu, Shunying Li, Qianfeng Shi, Qian Li, Yanqing Wu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-r
Autor:
Jun Yong Lee, David J. Mooney, Bo Ri Seo, David M. Wu, Catia S. Verbeke, Miguel C. Sobral, Hua Wang, Aileen Weiwei Li, Alexander J. Najibi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Poorly immunogenic tumors, including triple negative breast cancers (TNBCs), remain resistant to current immunotherapies, due in part to the difficulty of reprogramming the highly immunosuppressive tumor microenvironment (TME). Here we show that peri
Autor:
Ze-Lin Li, Ji-Hong Liu, Xin-Hong Zhu, Qiang-Long You, Xiaochun Bai, Neng-Yuan Hu, Yan Wang, Jian-Ming Yang, Jiang-Ping Xu, Shu-Ji Li, Zeng-Lin Jin, Tian-Ming Gao, Yifan Dai, Qian Wang, Xiao-Wen Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on n
Autor:
Hyun Guy Kang, Yi Jun Kim, Kyoung Min Lee, Yongsik Cho, Jin-Hong Kim, Moon Jong Chang, Chong Bum Chang, Donghyeon Cheon, Hyeon Seop Kim, Hyeonkyeong Kim, Donghyun Kang, Seung Baik Kang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Chondrosarcomas, malignant cartilaginous neoplasms, are capable of transitioning to highly aggressive, metastatic, and treatment-refractory states, resulting in significant patient mortality. Here, we aim to uncover the transcriptional program direct