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Autor:
Seung Hoi Koo, Thomas Vargas, Jose E. Heredia, Yi Liu, John R. Yates, Marc Montminy, Susan Hedrick, Renaud Dentin
Publikováno v:
Nature. 449:366-369
During feeding, increases in circulating pancreatic insulin inhibit hepatic glucose output through the activation of the Ser/Thr kinase AKT and subsequent phosphorylation of the forkhead transcription factor FOXO1 (refs 1-3). Under fasting conditions