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Autor:
Tongtong Zhao, Zachary D. Chiang, Julia W. Morriss, Lindsay M. LaFave, Evan M. Murray, Isabella Del Priore, Kevin Meli, Caleb A. Lareau, Naeem M. Nadaf, Jilong Li, Andrew S. Earl, Evan Z. Macosko, Tyler Jacks, Jason D. Buenrostro, Fei Chen
Publikováno v:
Nature
The state and behavior of a cell can be influenced by both genetic and environmental factors. In particular, tumor progression is determined by underlying genetic aberrations(1–4) as well as the makeup of the tumor microenvironment(5,6). Quantifyin
Autor:
Jessica A. Stewart, Javier M. Di Noia, Amy Hin Yan Tong, Diana Nakib, Maribel Berru, Alberto Martin, Katherine Chan, Noé Seija Desivo, Gholam Ali Kardar, James R. Carlyle, Daniel Durocher, Rukshana Mohamad-Ramshan, Yuqing Feng, Jason Moffat, Madusha L. W. Perera, Rossanna C. Pezo, Alejandro Álvarez-Quilón, Philip Barbulescu, Ashok S. Bhagwat, Gavin Li, Conglei Li
Publikováno v:
Nature
Activation-induced cytidine deaminase (AID) catalyses the deamination of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and class-switch recombination1,2. AID-generated deoxyuracils are recognized and proce
Autor:
Elmir Mahammadov, Shota Nakanoh, Shankar Srinivas, Ludovic Vallier, Antonio Scialdone, Richard C. V. Tyser
Publikováno v:
Nature 600, 285-289 (2021)
Gastrulation is the fundamental process in all multicellular animals through which the basic body plan is first laid down1–4. It is pivotal in generating cellular diversity coordinated with spatial patterning. In humans, gastrulation occurs in the
Autor:
Ravi C. Kalathur, SangJoon Lee, Thirumala-Devi Kanneganti, Lam Nhat Nguyen, Rajendra Karki, Yaqiu Wang
Publikováno v:
Nature. 597:415-419
Inflammasomes are important sentinels of innate immune defence, sensing pathogens and inducing cell death in infected cells1. There are several inflammasome sensors that each detect and respond to a specific pathogen- or damage-associated molecular p
Autor:
Jialiang Guan, Jie Chen, Dong Wang, Peixue Xia, Yi Li, Yuhui Ou, Ying Liu, Jie Wang, Rong Luo, Peng Chen
Publikováno v:
Nature. 596:281-284
The mTOR complex 1 (mTORC1) controls cell growth in response to amino acid levels1. Here we report SAR1B as a leucine sensor that regulates mTORC1 signalling in response to intracellular levels of leucine. Under conditions of leucine deficiency, SAR1
Autor:
Yeqing Angela Yang, Christian Cox, Matthew B. Buechler, Zora Modrusan, Merone Roose-Girma, Rachana N. Pradhan, Roger Caothien, Richard Bourgon, Sören Müller, Amber W. Wang, Akshay T. Krishnamurty, Shannon J. Turley, Aslihan Karabacak Calviello, Joseph R. Arron, Lucinda Tam
Publikováno v:
Nature. 593:575-579
Fibroblasts are non-haematopoietic structural cells that define the architecture of organs, support the homeostasis of tissue-resident cells and have key roles in fibrosis, cancer, autoimmunity and wound healing1. Recent studies have described fibrob
Autor:
Carmen Sonntag, Laura A. Galvis, Phong D. Nguyen, Fernando J. Rossello, Jeroen Bakkers, Christophe Marcelle, Kelly L. Rogers, Verena C. Wimmer, Ziad Julier, Abdulsalam I. Isiaku, Thomas Boudier, Mikaël M. Martino, Dhanushika Ratnayake, Silke Berger, Jean Tan, Graham J. Lieschke, A.J. Wood, Peter D. Currie, Viola Oorschot
Publikováno v:
Nature, 591(7849), 281-287. Nature Publishing Group
Skeletal muscle regenerates through the activation of resident stem cells. Termed satellite cells, these normally quiescent cells are induced to proliferate by wound-derived signals1. Identifying the source and nature of these cues has been hampered
Autor:
Li Wang, Berta Pozzi, Jenna N. Kelly, Malania M. Wilson, Fabien Labroussaa, Nannan Jiang, Charaf Benarafa, Jasmine Portmann, John R. Barnes, Matthew W. Keller, Volker Thiel, Bin Zhou, Bernd Hoffmann, Joerg Jores, Lorenz Ulrich, Silvio Steiner, Jacqueline King, Tran Thi Nhu Thao, Ronald Dijkman, Xiaoyu Fan, Nico Joel Halwe, David E. Wentworth, Hanspeter Stalder, Dan Cui, Bettina Salome Trüeb, Jaber Hossain, Simone de Brot, Donata Hoffmann, Thomas J. Stark, Martin Beer, Xudong Lin, Anne Pohlmann, Adriano Taddeo, Lisa Thomann, Nadine Ebert
Publikováno v:
Nature
During the evolution of SARS-CoV-2 in humans, a D614G substitution in the spike glycoprotein (S) has emerged; virus containing this substitution has become the predominant circulating variant in the COVID-19 pandemic1. However, whether the increasing
Autor:
Victor Thiruthuvanathan, Susmita Kaushik, Edward Nieves, Yun Ruei Kao, Julie A. Reisz, Qian Wang, Britta Will, Ana Maria Cuervo, Angelo D'Alessandro, Shuxian Dong, Inmaculada Tasset, Evripidis Gavathiotis, Aliona Zintiridou, Monika Dzieciatkowska, Antonio Diaz
Publikováno v:
Nature
Cell Res
Cell Res
The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-long production of blood cells1. This process requires major molecular adaptations to allow HSCs to meet the regulatory and metabolic requirements for cell
Autor:
Bruce R. Ksander, Morgan E. Levine, Emma Hoffmann, Luis A. Rajman, Zhigang He, Meredith S Gregory-Ksander, Michael Bonkowski, Anitha Krishnan, Jae-Hyun Yang, Chen Wang, Alice E. Kane, Ekaterina Korobkina, Songlin Zhou, Xiao Tian, Margarita Meer, George M. Church, Yu D, Michael B. Schultz, Karolina Chwalek, Noah Davidsohn, Steve Horvath, Yuancheng Lu, Qiurui Zeng, Konrad Hochedlinger, David A. Sinclair, Daniel L. Vera, Vadim N. Gladyshev, Margarete M. Karg, Benedikt Brommer
Publikováno v:
Nature
Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause of ageing is the accumulation of epigenetic noise that disrupts gene expression patterns, leading to decreases in tissue function and regenerative capacity1