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Autor:
A. Coutrot, E. Manley, S. Goodroe, C. Gahnstrom, G. Filomena, D. Yesiltepe, R. C. Dalton, J. M. Wiener, C. Hölscher, M. Hornberger, H. J. Spiers
Publikováno v:
Nature. 604:104-110
The cultural and geographical properties of the environment have been shown to deeply influence cognition and mental health1-6. Living near green spaces has been found to be strongly beneficial7-11, and urban residence has been associated with a high
Autor:
Guanghui Dong, Sihao Wu, Yang Xu, Qingyan Dai, Xingjun Hu, Chao Ning, Idilisi Abuduresule, Xiaotian Feng, Linyuan Fan, Zihua Tang, Qiaomei Fu, Martine Robbeets, Chunxiang Li, Choongwon Jeong, Wenying Li, Pengcheng Ma, Yinqiu Cui, Wenjun Wang, Rasmus Bjørn, Hui Zhou, Feng Liu, Alipujiang Niyazi, R. Yang, Ashley Scott, Johannes Krause, Shao-Qing Wen, Qiurong Ruan, Shizhu Gao, Fan Zhang, Hong Zhu, Peng Cao, Vikas Kumar, Christina Warinner, Dong Wei
Publikováno v:
Nature
The identity of the earliest inhabitants of Xinjiang, in the heart of Inner Asia, and the languages that they spoke have long been debated and remain contentious1. Here we present genomic data from 5 individuals dating to around 3000–2800 bc from t
Autor:
Fuyuki Kametani, Ruben Vidal, Mike van Beers, Abhay Kotecha, H. Tanaka, Airi Tarutani, Tammaryn Lashley, Wenjuan Zhang, Yang Yang, Yang Shi, Benjamin Falcon, Takeshi Ikeuchi, Michel Goedert, Sjors H.W. Scheres, Holly J. Garringer, Bernardino Ghetti, Gabor G. Kovacs, Mari Yoshida, Masato Hasegawa, Akiyoshi Kakita, Alexey G. Murzin, Andrew C Robinson, David M. A. Mann, Tamas Revesz, Yuko Saito, G.I. Hallinan, Shigeo Murayama
Publikováno v:
Nature
Shi, Y, Zhang, W, Yang, Y, Murzin, A G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H J, Vidal, R, Hallinan, G I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A C, Mann, D M A, Kovacs, G G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M & Scheres, S H W 2021, ' Structure-based classification of tauopathies ', Nature, vol. 598, no. 7880, pp. 359-363 . https://doi.org/10.1038/s41586-021-03911-7
Shi, Y, Zhang, W, Yang, Y, Murzin, A G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H J, Vidal, R, Hallinan, G I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A C, Mann, D M A, Kovacs, G G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M & Scheres, S H W 2021, ' Structure-based classification of tauopathies ', Nature, vol. 598, no. 7880, pp. 359-363 . https://doi.org/10.1038/s41586-021-03911-7
Ordered assembly of the tau protein into filaments characterizes multiple neurodegenerative diseases, which are called tauopathies. We previously reported that by electron cryo-microscopy (cryo-EM), tau filament structures from Alzheimer’s disease
Autor:
Andrew D. Chisholm, Richard Schalek, Yufang Liu, Wan Xian Koh, Ben Mulcahy, Jeff W. Lichtman, Yaron Meirovitch, Yuelong Wu, Daniel R. Berger, James K. Mitchell, Rajeev Parvathala, Douglas Holmyard, Nir Shavit, Mei Zhen, Daniel Witvliet, Aravinthan D. T. Samuel
Publikováno v:
Nature
An animal’s nervous system changes as its body grows from birth to adulthood and its behaviours mature1–8. The form and extent of circuit remodelling across the connectome is unknown3,9–15. Here we used serial-section electron microscopy to rec
Publikováno v:
Nature
Ageing is driven by a loss of cellular integrity1. Given the major role of ubiquitin modifications in cell function2, here we assess the link between ubiquitination and ageing by quantifying whole-proteome ubiquitin signatures in Caenorhabditis elega
Autor:
Francisco Martínez-Jiménez, Abel Gonzalez-Perez, Nuria Lopez-Bigas, Ferran Muiños, Oriol Pich
Publikováno v:
Nature. 596:428-432
Despite the existence of good catalogues of cancer genes1,2, identifying the specific mutations of those genes that drive tumorigenesis across tumour types is still a largely unsolved problem. As a result, most mutations identified in cancer genes ac
Publikováno v:
Nature. 595:205-213
Social and cultural forces shape almost every aspect of infectious disease transmission in human populations, as well as our ability to measure, understand, and respond to epidemics. For directly transmitted infections, pathogen transmission relies o
Autor:
Sumana Chakravarty, Eric R. James, Stephen L. Hoffman, Lei K. Ding, Jillian Neal, Charles Wyatt, Sahand Kalhori, Anita Manoj, Alemush Imeru, Omely Marte-Salcedo, Sangeeta N. Bhatia, Hope Decederfelt, David M. Cook, Agnes Mwakingwe-Omari, Martha Nason, Jen C. C. Hume, Sara A. Healy, Aarti Kolluri, Natasha Kc, Ijeoma Ikpeama, B. Kim Lee Sim, Peter F. Billingsley, Sean C. Murphy, L. W. Preston Church, Jihyun E. Jeon, Sandra March, Grace K. Lee, Irfan Zaidi, Jacob Raiten, Junhui Duan, Anusha Gunasekera, Thomas L. Richie, Tooba Murshedkar, Jacquelyn Lane, Patrick E. Duffy, Charles Anderson
Publikováno v:
Nature. 595:289-294
The global decline in malaria has stalled1, emphasizing the need for vaccines that induce durable sterilizing immunity. Here we optimized regimens for chemoprophylaxis vaccination (CVac), for which aseptic, purified, cryopreserved, infectious Plasmod
Autor:
Kenneth A. Ohgi, Aneel K. Aggarwal, Michael G. Rosenfeld, Fan Yang, Bogdan Tanasa, Rudi Micheletti
Publikováno v:
Nature
The size of the transcriptional program of long non-coding RNAs in the mammalian genome has engendered discussions about their biological roles1, particularly the promoter antisense (PAS) transcripts2,3. Here we report the development of an assay—r
Autor:
Ruohan Zhang, Scott T. Retterer, Baron Chanda, Randall H. Goldsmith, Vinay Idikuda, Sandipan Chowdhury, David S. White
Publikováno v:
Nature
Electrical activity in the brain and heart depends on rhythmic generation of action potentials by pacemaker ion channels (HCN) whose activity is regulated by cAMP binding1. Previous work has uncovered evidence for both positive and negative cooperati