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Autor:
Nobuyoshi Ishii, Masaru Tomita, Hisami Watanabe, Masayuki Honma, Yuki Takai, Hirotada Mori, Tomoyoshi Soga, Miki Hasegawa, Kenji Nakahigashi, Yoshihiro Toya
Publikováno v:
Molecular Systems Biology
Central carbon metabolism is a basic and exhaustively analyzed pathway. However, the intrinsic robustness of the pathway might still conceal uncharacterized reactions. To test this hypothesis, we constructed systematic multiple‐knockout mutants inv
Publikováno v:
Molecular Systems Biology
Promoters control the expression of genes in response to one or more transcription factors (TFs). The architecture of a promoter is the arrangement and type of binding sites within it. To understand natural genetic circuits and to design promoters fo
Autor:
Ofer Biham, Gilgi Friedlander, Yishai Shimoni, Gali Niv, Hanah Margalit, Shoshy Altuvia, Guy Hetzroni
Publikováno v:
Molecular Systems Biology
The importance of post-transcriptional regulation by small non-coding RNAs has recently been recognized in both pro- and eukaryotes. Small RNAs (sRNAs) regulate gene expression post-transcriptionally by base pairing with the mRNA. Here we use dynamic
Publikováno v:
Molecular Systems Biology
Molecular systems biology, vol 3, iss 1
Molecular systems biology, vol 3, iss 1
Microorganisms use genetic circuits to integrate environmental information. We have constructed a synthetic AND gate in the bacterium Escherichia coli that integrates information from two promoters as inputs and activates a promoter output only when
Autor:
Johannes B. Goll, Jodi R. Parrish, Peter Uetz, Hirotada Mori, Seesandra V. Rajagopala, Timothy Palzkill, Björn Titz, Katrin Wohlbold, Russell L. Finley, Matthew McKevitt
Publikováno v:
Molecular Systems Biology
Motility is achieved in most bacterial species by the flagellar apparatus. It consists of dozens of different proteins with thousands of individual subunits. The published literature about bacterial chemotaxis and flagella documented 51 protein?prote
Autor:
Ronish Gupta, Nevan J. Krogan, Bart Kus, John Parkinson, Sachdev S. Sidhu, Christopher Fladd, James D. Wasmuth, Daniela Rotin, Raffi Tonikian
Publikováno v:
Molecular Systems Biology
Ubiquitin-protein ligases (E3s) are responsible for target recognition and regulate stability, localization or function of their substrates. However, the substrates of most E3 enzymes remain unknown. Here, we describe the development of a novel prote
Publikováno v:
Molecular Systems Biology; Vol 7
Molecular Systems Biology
Molecular Systems Biology
How can cancer cells survive the consequences of cyt-c release? Huber et al provide a quantitative analysis of the protective role of enhanced glucose utilization in cancer cells and investigate the impact of cell-to-cell heterogeneity in mitochondri
Autor:
Adina Weinberger, Maya Lotan-Pompan, Uri Barenholz, Leeat Keren, Ora Zackay, Erez Dekel, Anat Bren, Uri Alon, Vered Sasson, Eran Segal, Guy Aidelberg, Danny Zeevi, Ron Milo
Publikováno v:
Molecular Systems Biology
Libraries of S. cerevisiae and E. coli promoter reporters measured under different conditions reveal scaling relationships between expression profiles across conditions and suggest that most changes in activity are due to global effects.
Between
Between
Autor:
Alina Isakova, Jean-Daniel Feuz, Carine Gubelmann, Jovan Simicevic, Sunil K. Raghav, Wiebke Holcombe, Bart Deplancke, Sebastian M. Waszak, Antonina Iagovitina, Korneel Hens
Publikováno v:
Molecular Systems Biology
A combined cross-platform approach is presented to experimentally identify and characterize interactions between mouse transcription factors and regulatory elements at unprecedented resolution and throughput.
We generated a mouse-specific transc
We generated a mouse-specific transc
Autor:
Nils Johnsson, Johann M. Kraus, Joachim Neller, Daniel Moreno, Alexander Dünkler, Hans A. Kestler
Publikováno v:
Molecular Systems Biology
A method based on a combination of the Split-Ubiquitin system with two spectrally different fluorescent proteins (SPLIFF) is shown to enable measurement of protein interactions in vivo with high spatial and temporal resolution in yeast.
SPLIFF v
SPLIFF v