Zobrazeno 1 - 10
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pro vyhledávání: ''
Autor:
Terri Gelbart, D L Graham, G E Sandusky, Anantha Shekhar, J O Niezer, Daniel R. Salomon, A. Williams, Sunil M. Kurian, H L Dainton, A Ballew, Helen Le-Niculescu, T. Jones, E M Niculescu, K. Roseberry, V Venugopal, Daniel F. Levey, Nicholas J. Schork, M Yard, Alexander B. Niculescu, Peter Phalen
Publikováno v:
Molecular Psychiatry
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identific
Publikováno v:
Molecular Psychiatry
Chronic stress can be a precipitating factor in the onset of depression. Lentiviral-mediated knockdown of HCN1 protein expression and reduction of functional Ih produce antidepressant behavior. However, whether h-channels are altered in an animal mod
Autor:
L. Fernández de la Cruz, David Mataix-Cols, Catarina Almqvist, Gustaf Brander, Ralf Kuja-Halkola, Paul Lichtenstein, Eva Serlachius, Mina Rydell, Henrik Larsson, Christian Rück, Brian M. D’Onofrio
Publikováno v:
Molecular Psychiatry
Adverse perinatal events may increase the risk of Tourette’s and chronic tic disorders (TD/CTD), but previous studies have been unable to control for unmeasured environmental and genetic confounding. We aimed to prospectively investigate potential
Autor:
Wei Gan, Julien Vaucher, Guillaume Paré, Aurélie M. Lasserre, Brendan J. Keating, Michael V. Holmes, Daniel J. Smith, Naveed Sattar, Joey Ward, Jill P. Pell, Donald M. Lyall
Publikováno v:
Molecular Psychiatry
Molecular psychiatry, vol. 23, no. 5, pp. 1287-1292
Molecular psychiatry, vol. 23, no. 5, pp. 1287-1292
Cannabis use is observationally associated with an increased risk of schizophrenia, but whether the relationship is causal is not known. Using a genetic approach, we took 10 independent genetic variants previously identified to associate with cannabi
Autor:
John A. Bilello, Bradford C. Dickerson, Gustavo Kinrys, Linda M. Thurmond, Marlene P. Freeman, Bettina B. Hoeppner, David Mischoulon, K Johe, Larry Ereshefsky, Maurizio Fava, Martina Flynn, J Johnstone, L G Gertsik, Brett A. English, Nikos Makris
Publikováno v:
Molecular Psychiatry
We wanted to examine tolerability and efficacy of NSI-189, a benzylpiperizine-aminiopyridine neurogenic compound for treating major depressive disorder (MDD). This was a Phase 1B, double blind, randomized, placebo controlled, multiple-dose study with
Publikováno v:
Molecular Psychiatry
Survival analyzes are usually based on a single point in time predefined event. Dissatisfied with this approach to evaluating maintenance treatment outcomes, we developed the Multi-state Outcome Analysis of Treatments (MOAT) methodology using a combi
Autor:
H Duckworth, A Ballew, Daniel R. Salomon, M Ayalew, Robert Schweitzer, Sunil M. Kurian, K Olesek, E Bellanger, N Jain, Evan A. Winiger, M Yard, S Bhosrekar, L M Gavrin, G E Sandusky, H Le-Niculescu, G Shankar, Nicholas J. Schork, L Palmer, Daniel F. Levey, J Vergo, Alexander B. Niculescu, Anantha Shekhar, M Radel
Publikováno v:
Molecular Psychiatry
Suicides are a leading cause of death in psychiatric patients, and in society at large. Developing more quantitative and objective ways (biomarkers) for predicting and tracking suicidal states would have immediate practical applications and positive
Autor:
Peter Boesiger, Dominique J.-F. de Quervain, Klaus Scheffler, Amanda Aerni, Christian Vogler, Sandra Ackermann, Kostic, Andreas Papassotiropoulos, Edveena Hanser, Kim-Dung Huynh, Roger Luechinger, Markus Klarhöfer, Philippe Demougin, Leo Gschwind, Elka Stefanova, Klara Spalek, Ivana Novakovic, Angela Heck, Björn Rasch
Publikováno v:
Molecular Psychiatry; Vol 18
Molecular Psychiatry
Molecular psychiatry
Molecular Psychiatry
Molecular psychiatry
Unbiased genome wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome wide screen to identify episodic memory related gene variants. A genomic locu
Autor:
Renee Testa, Christos Pantelis, Efstratios Skafidas, Ian P. Everall, Daniela Zantomio, Gursharan Chana
Publikováno v:
Molecular Psychiatry
Autism spectrum disorder (ASD) depends on a clinical interview with no biomarkers to aid diagnosis. The current investigation interrogated single-nucleotide polymorphisms (SNPs) of individuals with ASD from the Autism Genetic Resource Exchange (AGRE)
Antemortem biomarker support for a diagnosis of clinically probable chronic traumatic encephalopathy
Publikováno v:
Molecular Psychiatry
Antemortem biomarker support for a diagnosis of clinically probable chronic traumatic encephalopathy