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Autor:
Abdallah Hamze, Marie-Edith Rafestin-Oblin, Jean-Daniel Brion, Jérôme Fagart, Abdellatif Tikad, Michel Fay, Mouad Alami, Nathalie Chabbert-Buffet, Hugues Loosfelt, Larbi Amazit, Geri Meduri, Marc Lombès, Junaid Ali Khan
Publikováno v:
Molecular Endocrinology. 27:909-924
Currently available progesterone (P4) receptor (PR) antagonists, such as mifepristone (RU486), lack specificity and display partial agonist properties, leading to potential drawbacks in their clinical use. Recent x-ray crystallographic studies have i
Autor:
Grant Buchanan, Luke A. Selth, Tiffany J. Harris, Stephen N. Birrell, Wayne D. Tilley, Eleanor F. Need
Publikováno v:
Molecular Endocrinology. 26:1941-1952
The cellular response to circulating sex steroids is more than the sum of individual hormone actions, instead representing an interplay between activities of the evolutionarily related steroid hormone receptors. An example of this interaction is in b
Autor:
Timothy Cardozo, Ritu Goyanka, Sharmistha Das, Matthieu Schapira, Marjana Tomic-Canic, Herbert H. Samuels
Publikováno v:
Molecular Endocrinology. 21:2672-2686
In silico docking of a chemical library with the ligand-binding domain of thyroid hormone nuclear receptor-beta (TRbeta) suggested that farnesyl pyrophosphate (FPP), a key intermediate in cholesterol synthesis and protein farnesylation, might functio
Autor:
Ai Li Yeo, Peter Nowotny, Maria Nilsson, Edison T. Liu, Thomas M. Stulnig, Chin-Yo Lin, Knut R. Steffensen
Publikováno v:
Molecular Endocrinology. 21:126-137
The nuclear hormone receptors liver X receptor α (LXRα) (NR1H3) and LXRβ (NR1H2) are established regulators of cholesterol, lipid, and glucose metabolism and are attractive drug targets for the treatment of diabetes and cardiovascular disease. Adr
Publikováno v:
Molecular Endocrinology. 20:2062-2079
FSH is produced by the pituitary gonadotrope to regulate gametogenesis. Steroid hormones, including androgens, progestins, and glucocorticoids, have all been shown to stimulate expression of the FSHβ subunit in primary pituitary cells and rodent mod
Autor:
Michelle M. Tabb, Bruce Blumberg
Publikováno v:
Molecular Endocrinology. 20:475-482
Endocrine-disrupting chemicals (EDC) are commonly considered to be compounds that mimic or block the transcriptional activation elicited by naturally circulating steroid hormones by binding to steroid hormone receptors. For example, the Food Quality
Autor:
Ronald M. Evans
Publikováno v:
Molecular Endocrinology. 19:1429-1438
In the December 1985 issue of Nature, we described the cloning of the first nuclear receptor cDNA encoding the human glucocorticoid receptor (GR) (1). In the 20 yr since that event, our field has witnessed a quantum leap by the subsequent discovery a
Autor:
Elwood V. Jensen
Publikováno v:
Molecular Endocrinology. 19:1439-1442
In the 47 yr since the first evidence for a steroid hormone receptor was presented at an international congress to an audience of five persons, the concept of “alternative approach” has played an important role in providing new understanding. By
Autor:
Walter L. Miller, Ningwu Huang
Publikováno v:
Molecular Endocrinology. 19:409-420
The cholesterol side-chain cleavage enzyme, P450scc, initiates biosynthesis of all steroid hormones. Adrenal and gonadal P450scc expression requires steroidogenic factor-1 (SF1), but P450scc expression in human placental JEG-3 cells utilizes an SF1-i
Autor:
Anthony W. Norman, June E. Bishop, Christopher J. Olivera, Laura P. Zanello, Johanna A. Huhtakangas
Publikováno v:
Molecular Endocrinology. 18:2660-2671
The steroid hormone 1α,25(OH)2-vitamin D3 (1,25D) regulates gene transcription through a nuclear receptor [vitamin D receptor (VDR)] and initiation of rapid cellular responses through a putative plasma membrane-associated receptor (VDRmem). This stu