Zobrazeno 1 - 10
of 25
pro vyhledávání: ''
Publikováno v:
Molecular Endocrinology. 28:197-207
Insulin, an established mitogen that promotes breast cancer cell growth, has been implicated in the link between obesity and an increased risk of breast cancer. However, the current understanding of signaling pathways that mediate the mitogenic actio
Autor:
Abdallah Hamze, Marie-Edith Rafestin-Oblin, Jean-Daniel Brion, Jérôme Fagart, Abdellatif Tikad, Michel Fay, Mouad Alami, Nathalie Chabbert-Buffet, Hugues Loosfelt, Larbi Amazit, Geri Meduri, Marc Lombès, Junaid Ali Khan
Publikováno v:
Molecular Endocrinology. 27:909-924
Currently available progesterone (P4) receptor (PR) antagonists, such as mifepristone (RU486), lack specificity and display partial agonist properties, leading to potential drawbacks in their clinical use. Recent x-ray crystallographic studies have i
Autor:
Grant Buchanan, Luke A. Selth, Tiffany J. Harris, Stephen N. Birrell, Wayne D. Tilley, Eleanor F. Need
Publikováno v:
Molecular Endocrinology. 26:1941-1952
The cellular response to circulating sex steroids is more than the sum of individual hormone actions, instead representing an interplay between activities of the evolutionarily related steroid hormone receptors. An example of this interaction is in b
Autor:
Jonna Frasor, Sarah C. Baumgarten
Publikováno v:
Molecular Endocrinology. 26:360-371
Approximately 75% of breast tumors express the estrogen receptor (ER), and women with these tumors will receive endocrine therapy. Unfortunately, up to 50% of these patients will fail ER-targeted therapies due to either de novo or acquired resistance
Autor:
Kathryn B. Horwitz
Publikováno v:
Molecular Endocrinology. 22:2743-2750
This transcript is based on my The Year in Basic Science lecture at ENDO 2008. I reviewed current data surrounding hormone replacement therapy and the relationship between systemic estrogen plus progestin (E+P) treatment and increased breast cancer r
Autor:
Suzanne D. Conzen
Publikováno v:
Molecular Endocrinology. 22:2215-2228
Until recently, the study of nuclear receptor (NR) function in breast cancer biology has been largely limited to estrogen and progesterone receptors. The development of reliable gene expression arrays, real-time quantitative RT-PCR, and immunohistoch
Autor:
Sujit S. Nair, Darrell W Brann, Dujin Zhou, Rajib Rajhans, Valerie Cortez, Hareesh B. Nair, Ratna K. Vadlamudi, Nameer B. Kirma, Alan E.C. Holden, Kijima Ikuko, Rajeshwar Rao Tekmal, Shiuan Chen
Publikováno v:
Molecular Endocrinology. 22:649-664
In situ estrogen synthesis is implicated in tumor cell proliferation through autocrine or paracrine mechanisms especially in postmenopausal women. Several recent studies demonstrated activity of aromatase, an enzyme that plays a critical role in estr
Autor:
Elwood V. Jensen
Publikováno v:
Molecular Endocrinology. 19:1439-1442
In the 47 yr since the first evidence for a steroid hormone receptor was presented at an international congress to an audience of five persons, the concept of “alternative approach” has played an important role in providing new understanding. By
Publikováno v:
Molecular Endocrinology. 19:312-326
We evaluated the signaling pathways involved in regulating vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, in response to natural and synthetic progestins in breast cancer cells. Inhibition of the phosphoinositide-3′-k
Publikováno v:
Molecular Endocrinology. 18:1396-1410
Estrogen receptor alpha (ERalpha) negative breast tumors often present with enhanced expression and/or activation of growth factor receptors, resulting in increased growth factor signaling and hyperactivation of MAPK (ERK1 and ERK2). We have pre-viou