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Autor:
Christian Hartmann, Anton Buzdin, Amir Samii, Ella Kim, Aleksey Moisseev, Maxim Sorokin, Andrew Garazha, Luidmila Makovskaia, Alf Giese, Souvik Kar
Publikováno v:
Cold Spring Harbor Molecular Case Studies
Glioblastoma multiforme (GBM) is the most malignant brain tumor with patient mortality rate close to 100%, 5-yr survival rate of ∼5%, and a median survival of 14 mo. GBMs have notorious histomorphologic and molecular heterogeneities thus giving hop
Autor:
Brian H. Ladle, Steven P. Rowe, Tingting Liu, Allen R. Chen, Christine A. Pratilas, Matthew D. Merguerian
Publikováno v:
Cold Spring Harbor Molecular Case Studies
Treatment of high-risk neuroblastoma typically incorporates multiagent chemotherapy, surgery, radiation therapy, autologous stem cell transplantation, immunotherapy, and differentiation therapy. The discovery of activating mutations in ALK receptor t
Publikováno v:
Molecular Case Studies. 6:a005785
Tyrosine kinase inhibitors (TKIs) have transformed the standard of care in lung cancer. A number of TKIs have been discovered that specifically target oncogenes, including MET receptor tyrosine kinase. Second-generation MET TKIs are showing improved
Autor:
Selene C. Koo, Bhuvana A. Setty, Kristen M. Leraas, Peter White, Jennifer A. Belsky, Catherine E. Cottrell, Kris R. Jatana, Sean McGrath, Richard K. Wilson, Elaine R. Mardis, Kathleen M. Schieffer, Ajay Gupta, Vincent Magrini, Elizabeth Varga
Publikováno v:
Molecular Case Studies. 6:a005645
Infantile fibrosarcoma (IFS) is nearly universally driven by gene fusions involving the NTRK family. ETV6-NTRK3 fusions account for ∼85% of alterations; the remainder are attributed to NTRK-variant fusions. Rarely, other genomic aberrations have be
Autor:
Jason Roszik, Shiao Pei Weathers, Marta Penas-Prado, Ryuma Tanaka, Soumen Khatua, Amini Behrang, Wafik Zaky, Filip Janku, Shiraj Sen, Vivek Subbiah
Publikováno v:
Molecular Case Studies. 6:a005041
Although BRAF inhibition has demonstrated activity in BRAFV600–mutated brain tumors, ultimately these cancers grow resistant to BRAF inhibitor monotherapy. Parallel activation of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathw
Autor:
Albrecht Stenzinger, Volker Endris, Michael Thomas, Steffen Dietz, Lisa Gu, Tomasz Zemojtel, Matthias Schlesner, Martin Reck, Simon J. Ogrodnik, Petros Christopoulos, Marc A. Schneider, Claus Peter Heussel, Zhao Yuan, Michael Meister, Thomas Muley, Holger Sültmann, Anna-Lena Volckmar
Publikováno v:
Molecular Case Studies. 5:a004630
Genetic rearrangements involving the anaplastic lymphoma kinase (ALK) gene confer sensitivity to ALK tyrosine kinase inhibitors (TKIs) and superior outcome in non-small-cell lung cancer (NSCLC). However, clinical courses vary widely, and recent studi
Autor:
Lauren L. Young, Margaret Rosenzweig, Rachel L. Erlich, Theodore W. Laetsch, Dinesh Rakheja, Yanbin Zheng, Priscilla Liem, Patrick J. Leavey, Siraj M. Ali, Angshumoy Roy, Raphael Wilson, D. Williams Parsons, Erin Butler, Mohammed Hassan, Stephen X. Skapek, Dean Pavlick
Publikováno v:
Molecular Case Studies. 5:a004440
Infantile myofibromatosis (IM) is an aggressive neoplasm composed of myofibroblast-like cells in children. Although typically localized, it can also present as multifocal disease, which represents a challenge for effective treatment. IM has previousl
Autor:
Carlos Pagan, Anjali Saqi, Helen Fernandes, Subit Barua, Vundavalli V. Murty, Mahesh M. Mansukhani, Susan J. Hsiao
Publikováno v:
Cold Spring Harbor Molecular Case Studies
Assessment of ALK gene rearrangements is strongly recommended by the Molecular Testing Guideline for Selection of Lung Cancer Patients proposed by IASLC, AMP, and CAP at the time of diagnosis for patients with advanced stage disease. Non-small-cell l
Autor:
Greg Taylor, Jasleen K. Grewal, Jenny J. Ko, Christian Kollmannsberger, Kasmintan A. Schrader, Steven J.M. Jones, My Linh Thibodeau, Marco A. Marra, Andrew J. Mungall, Janessa Laskin, Tony Ng, Yaoqing Shen, Jean-Michel Lavoie
Publikováno v:
Cold Spring Harbor Molecular Case Studies
Thyroid-like follicular renal cell carcinoma (TLFRCC) is a rare cancer with few reports of metastatic disease. Little is known regarding genomic characteristics and therapeutic targets. We present the clinical, pathologic, genomic, and transcriptomic
Autor:
Christopher Dardis, Winnie S. Liang, Jonathan Adkins, Daniel Enriquez, Sara A. Byron, Adrienne Helland, Shobana Sekar, Andrew S. Little, Lori Cuyugan
Publikováno v:
Cold Spring Harbor Molecular Case Studies
Chordoma is a rare, orphan cancer arising from embryonal precursors of bone. Surgery and radiotherapy (RT) provide excellent local control, often at the price of significant morbidity because of the structures involved and the need for relatively hig