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Autor:
Ritsu Sumiyoshi, Haruko Tashiro, Ryosuke Shirasaki, Takuji Matsuo, Tadashi Yamamoto, Kensuke Matsumoto, Jun Ooi, Naoki Shirafuji
Publikováno v:
Leukemia research. 113
The role of the FMS-like tyrosine kinase 3 (FLT3) gene in acute myeloid leukemia (AML) has been well documented and the FLT3-internal tandem duplication (FLT3-ITD) mutation has been identified as a prognostic factor in AML. Due to its low incidence,
Autor:
Jane L. Liesveld, Haley Misch, Andrea Baran, Michael W. Becker, Kristen M. O'Dwyer, Mitra Azadniv, Katherine Nedrow, Kah Poh Loh, Jason H. Mendler
Publikováno v:
Leukemia research. 112
A phase II study was conducted to ascertain whether sequential exposure to decitabine followed by rapamycin, an mTOR (mechanistic target of rapamycin) inhibitor would result in better responses than decitabine alone. Newly diagnosed acute myelogenous
Autor:
Keya Sha, Xuhui Liu, Peipei Ye, Shanhao Tang, Shuangyue Li, Xian xu Zhuang, Yin Lu, Lieguang Chen, Junjie Cao, Renzhi Pei, Yiyu Xie, Xiaojin Wu, Dong Chen, Xiaohong Du, Pisheng Zhang
Publikováno v:
Leukemia research. 110
In order to investigate the efficacy of lenalidomide, bortezomib and dexamethasone (VRD) induction chemotherapy regimen combined with tandem autologous stem cell transplantation (ASCT) in treating multi-hit multiple myeloma (MM), we analyzed 252 case
Autor:
Gregoire Calon, Virginia O. Volpe, Chetasi Talati, Abida Babu, Constantine Logothetis, Andrew T. Kuykendall, Nicole D. Vincelette, Pukhraz Basra, Jeffrey E. Lancet, David Gajzer, Rami S. Komrokji, Seongseok Yun, Qianxing Mo, David A. Sallman, Najla Al Ali, Kendra Sweet, Eric Padron, Onyee Chan, Ling Zhang
Publikováno v:
Leuk Res
Recent studies demonstrated that MYC epigenetically regulates AML cell survival and differentiation by suppressing IDH1/2-TET2-5hmC signaling and that MYC overexpression is associated with poor survival outcomes in multiple AML patient cohorts. Howev
Autor:
Blanca Xicoy, Lurdes Zamora, Natalia Estrada, Marta Cabezón, Laura Martinez-Verbo, Laura Palomo, Olga García, Rosa Coll, Monserrat Arnan
Publikováno v:
Leukemia research. 111
Autor:
Veronika Everatt, Justinas Daraskevicius, Kazimieras Maneikis, Andrius Zucenka, Ugne Ringeleviciute, Vilmante Vaitekenaite
Publikováno v:
Leukemia research. 111
Publikováno v:
Leukemia research. 110
Autor:
Z V Martina, Nadia I. Bilous, I. Abramenko, Iryna Kryachok, Z P Fedorenko, A Chumak, Iryna Dyagil
Publikováno v:
Leukemia research. 110
The mutational status of the variable region of the immunoglobulin heavy chain (IGHV) genes remains the most significant prognostic factor in chronic lymphocytic leukemia (CLL) patients. However, the groups of mutated (M) and unmutated (UM) patients
Autor:
Mehmet Sinan Dal, Burcu Arslan Candır, Semih Başcı, Jale Yıldız, Bahar Uncu Ulu, Merih Kızıl Çakar, Sema Secilmis, Dicle İskender, Tahir Darçın, Fevzi Altuntaş, Tuğçe Nur Yiğenoğlu, Samet Yaman, Nuran Ahu Baysal, Derya Şahin, Ersin Bozan, Mehmet Bakırtaş
Publikováno v:
Leukemia research. 110
Diffuse large B cell lymphoma (DLBCL) has an increasing incidence in elderly patients with poorer prognosis than in younger patients. Clinicians should clearly identify the characteristics and prognostic factors of elderly patients. We analyzed the o
Autor:
Stephen Marcus, Eric Huselton, Amanda F. Cashen, Meagan A. Jacoby, Rizwan Romee, Iskra Pusic, Peter Westervelt, Michael P. Rettig, Feng Gao, Kirsten Campbell, Geoffrey L. Uy, John F. DiPersio, Mark A. Schroeder
Publikováno v:
Leukemia research. 110
Leukemia stem cells utilize cell adhesion molecules like CXCR4/CXCL12 to home to bone marrow stromal niches where they are maintained in a dormant, protected state. Dociparstat sodium (DSTAT, CX-01) is a low anticoagulant heparin with multiple mechan