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Publikováno v:
Journal of Pharmaceutical Sciences. 112:1705-1714
A modified in vitro-in vivo correlation (IVIVC) of the oral solid dosage forms has been proposed as a linear correlation between in vitro and in vivo dissolution. Nevertheless, the analysis of in vivo dissolution is limited by the lack of available m
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1667-1673
We aimed to understand the impact of the interplay between bile salts and cyclodextrins on the dissolution-permeation of poorly soluble drug compounds with a moderate-strong binding constant to cyclodextrin. Phase diagrams were prepared on the chosen
Autor:
Christopher Day, Fiona King, Diego Zulkiewicz Gomes, Richard E. Jones, Laurence James Harris, Nancy Lewen, Andrew Teasdale, Enid Gatimu, Grace Kocks, Ruth Boetzel, Susana Torres
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1421-1428
The purpose of this publication is to show how an elemental impurities excipient database can be used in assisting the execution of a drug product elemental impurities risk assessment as required by the ICH Q3D guidelines. As a result of this exercis
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1391-1400
We developed a composite system combining self-targeted carbon dots and thermosensitive in situ hydrogels for ocular drug delivery of diclofenac sodium (DS). DS-CDC-HP nanoparticles were prepared by loading DS on the surface of CDC-HP via electrostat
Autor:
Jaidev L. Chakka, Juliana C. Quarterman, Aliasger K. Salem, Dongrim Seol, James A. Martin, Youssef W. Naguib
Publikováno v:
J Pharm Sci
A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA). Viscosupplementation using a crosslinked hyaluronic acid
Autor:
Norman W. Barton, Mark D. Turner, Wanlu Qu, Dongdong Wang, Nazila Salamat-Miller, Jennifer S. Chadwick, Paul A. Salinas, Christopher McPherson
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1486-1496
The protein complex of recombinant human insulin-like growth factor-1 and insulin‑like growth factor binding protein‑3 (rhIGF-1/rhIGFBP-3; mecasermin rinfabate), is an investigational product for the prevention of complications of prematurity. De
Publikováno v:
J Pharm Sci
Carfilzomib (CFZ) is an FDA-approved proteasome inhibitor with antineoplastic properties against various cancers, yet its short blood retention time after intravenous injection (< 30 min) makes clinical applications limited to multiple myeloma. We pr
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1126-1132
Opalescence is a problem concerned with the stability of an antibody solution. It occurs when a high concentration of a protein is present. Arginine (Arg) is a versatile aggregation suppressor of proteins, which is among the candidates that suppress
Publikováno v:
Journal of Pharmaceutical Sciences. 111:710-716
The increase in solid fraction (SF) of a packed granule bed with pressure applied during the in-die compression process results in an evolution of the tablet's matrix and mechanical strength. In this case study, the tensile strength (TS) of a dry gra
Publikováno v:
Journal of Pharmaceutical Sciences. 111:485-494
The conjugation of chitosan (CS) and folic acid (FA) was prepared and used to coat PLGA nanoparticles (NPs) that are loaded with Docetaxel (DTX) to target cancer cells that have lower pH and overexpression of folate receptors in comparison to normal