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Publikováno v:
Journal of Pharmaceutical Sciences. 111:1391-1400
We developed a composite system combining self-targeted carbon dots and thermosensitive in situ hydrogels for ocular drug delivery of diclofenac sodium (DS). DS-CDC-HP nanoparticles were prepared by loading DS on the surface of CDC-HP via electrostat
Autor:
Jaidev L. Chakka, Juliana C. Quarterman, Aliasger K. Salem, Dongrim Seol, James A. Martin, Youssef W. Naguib
Publikováno v:
J Pharm Sci
A mitochondrial electron transport chain member complex I inhibitor, amobarbital, can reduce oxidative damage and chondrocyte death, eventually preventing post-traumatic osteoarthritis (PTOA). Viscosupplementation using a crosslinked hyaluronic acid
Publikováno v:
J Pharm Sci
Carfilzomib (CFZ) is an FDA-approved proteasome inhibitor with antineoplastic properties against various cancers, yet its short blood retention time after intravenous injection (< 30 min) makes clinical applications limited to multiple myeloma. We pr
Publikováno v:
Journal of Pharmaceutical Sciences. 111:417-431
This work aimed to develop a new efficient approach for safe treatment of psoriasis. To achieve that, resveratrol-loaded spanlastics(F1-F12) were prepared and evaluated by complete in vitro characterization. The two optimal formulations (F10 and F11)
Publikováno v:
Journal of Pharmaceutical Sciences. 111:517-528
Background Early assessment of pH-dependent drug-drug-interactions (DDIs) for salts of poorly soluble weakly acidic compounds offers various advantages for patient safety, the pharmaceutical industry, and regulatory bodies. Biorelevant media and test
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Sitagliptin Phosphate Monohydrate
Autor:
Rodrigo Cristofoletti, Mehul Mehta, Tomokazu Tajiri, Jennifer B. Dressman, Peter Langguth, James E. Polli, Naseem A. Charoo, Hassan A. Hassan, Daud Baraka Abdallah, Ahmed Abdalla Bakheit, Bertil Abrahamsson, Vinod P. Shah, Kashif Ul Haque, Alan F. Parr
Publikováno v:
Journal of Pharmaceutical Sciences. 111:2-13
Sitagliptin is an antihyperglycemic drug used in adults for the treatment of diabetes Type 2. Literature data and in-house experiments were applied in this monograph to assess whether methods based on the Biopharmaceutics Classification System (BCS)
Publikováno v:
Journal of Pharmaceutical Sciences. 111:82-87
Drug-drug cocrystals, which can regulate physicochemical properties of individual drugs and might produce synergistic therapeutic effects, have drawn growing interest in the pharmaceutical industry. In this study, a novel drug-drug (1:1) cocrystal hy
Publikováno v:
Guimaraes Sa Correia, M, Somville, P, Vertzoni, M & Fotaki, N 2021, ' Investigating the critical variables of azithromycin oral absorption using in vitro tests and PBPK Modeling ', Journal of Pharmaceutical Sciences, vol. 110, no. 12, pp. 3874-3888 . https://doi.org/10.1016/j.xphs.2021.09.013
Azithromycin is an antibiotic listed in the essential list of medicines for adults and pediatrics. Conflicting evidence has been found regarding azithromycin classification according to the Biopharmaceutics classification system (BCS). The purpose of
Autor:
Raj Suryanarayanan, Navpreet Kaur
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3743-3756
Even though levothyroxine sodium pentahydrate tablets have been in the market since 1955, there continue to be recalls due to sub potency. We have comprehensively reviewed the factors affecting its stability in solid oral dosage forms. A compilation
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3464-3470
The improvement effect of the combined use of spermine (SPM), a polyamine, with sodium taurocholate (STC) on the pulmonary drug absorption was investigated utilizing poorly absorbable drugs with various molecular sizes in rats. The pulmonary absorpti