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Publikováno v:
Journal of pharmaceutical sciences. 95(12)
Although displacement from plasma protein binding (dPB) is usually of little clinical significance, it should be taken into account when interpreting changes in total plasma concentrations of drugs subject to metabolically based drug-drug interaction
Publikováno v:
Journal of pharmaceutical sciences. 94(12)
The aim of this study was to evaluate whether or not starch acetate can act as a release-controlling excipient with physicochemically different drugs, using multivariate data analyses (PLS) for the modelling of drug release from starch acetate tablet
Publikováno v:
Journal of pharmaceutical sciences. 93(5)
Interleukin 2 (IL-2) is a pleotropic growth factor essential to immune system function. Current methods of administration are limited by the necessity of hospitalization as well as dose-limiting toxicities and side effects. There is also the issue of
Publikováno v:
Journal of pharmaceutical sciences. 93(4)
Acitretin, an active metabolite of etretinate, is as effective as etretinate in the treatment of psoriasis. Recently, we developed some water-soluble formulations of acitretin with 2-hydroxypropyl-beta-cyclodextrin (HPBCD)/randomly substituted methyl
Publikováno v:
Journal of pharmaceutical sciences. 91(6)
DPC 961 is a low-solubility, high-permeability, second-generation non-nucleoside reverse transcriptase inhibitor. The purpose of these studies was to evaluate the effects of drug substance and formulation variables on DPC 961 oral absorption, and to
Publikováno v:
Journal of pharmaceutical sciences. 89(12)
Studies have shown that the dose-limiting toxicity of amphotericin B (AmB), a key drug for systemic mycoses, depends on its self-aggregation state. In a step toward understanding the various factors in blood mediating the toxicity of AmB, we have inv
Autor:
Salomon A Stavchansky, Vaishali Pade
Publikováno v:
Journal of pharmaceutical sciences. 87(12)
The objective of this investigation was to establish a relationship between drug permeability and solubility in vitro and the extent of drug absorption in humans. We selected drugs with varying permeabilities and solubilities with the aim of establis
Autor:
Jukka Gynther, Tapio Nevalainen, Jarkko Rautio, Tomi Järvinen, Hannu Taipale, Jouko Vepsäläinen
Publikováno v:
Journal of pharmaceutical sciences. 87(12)
A series of acyloxyalkyl esters of ketoprofen and naproxen were synthesized and investigated as topical prodrugs with the aim of improving the dermal delivery of the drugs. In addition, some hydroxyalkyl esters of ketoprofen and naproxen were synthes
Autor:
C. Geraldine M. Jordan
Publikováno v:
Journal of pharmaceutical sciences. 87(7)
beta-Blockers including timolol and propranolol are administered in eye-drops for the treatment of glaucoma. Due to high incidence of cardiovascular and respiratory side-effects, their therapeutic value is limited. As a result of poor ocular bioavail
Publikováno v:
Journal of pharmaceutical sciences. 85(6)
The soft drug approach was applied to synthesize seven soft analogs of propantheline, which by design display predictable and controllable decomposition to inactive metabolites. Their synthesis involved the quatemization of several different amine gr