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Bridging the Gap Between In Vitro Dissolution and the Time Course of Ibuprofen-Mediating Pain Relief
Publikováno v:
Journal of pharmaceutical sciences. 105(12)
In vitro–in vivo extrapolation techniques combined with physiologically based pharmacokinetic models represent a feasible approach to establishing links between critical quality attributes and the time course of drug concentrations in vivo . By fur
Autor:
Leonid M. Berezhkovskiy
Publikováno v:
Journal of pharmaceutical sciences. 105(8)
An uncommon innovative consideration of the well-stirred linear physiologically based pharmacokinetic model and the drug plasma concentration-time profile, which is measured in routine intravenous bolus pharmacokinetic study, was applied for the calc
Autor:
Matteo D'Amore, Giuseppe Titomanlio, Anna Angela Barba, Sara Cascone, Gaetano Lamberti, Serafina Chirico
Publikováno v:
Journal of Pharmaceutical Sciences. 98:4100-4110
Design of systems for oral controlled release of drug could take advantages from the knowledge of which phenomena take place. In this work matrices obtained by powders compression (50:50, hydroxypropyl methylcellulose, a swelling hydrogel, and theoph
Publikováno v:
Journal of Pharmaceutical Sciences. 98:4264-4271
Topical monotherapy of nail diseases such as onychomycosis and nail psoriasis has been less successful due to poor permeability of the human nail plate to topically administered drugs. Chemical enhancers are utilized to improve the drug delivery acro
Autor:
Anthony P. Sileno, Charles Arthur Foerder, Conor J. Macevilly, Henry R. Costantino, Alexis Kays Leonard, Steven C. Quay
Publikováno v:
Journal of Pharmaceutical Sciences. 94:1736-1746
The goal of the current study was to develop an intranasal (IN) formulation of the acetylcholinesterase inhibitor galantamine, an important therapeutic for treating Alzheimer's disease. To allow for delivering a therapeutically relevant dose, it was
Publikováno v:
Journal of Pharmaceutical Sciences. 85:1044-1048
The serum drug levels and pharmacological effects of leuprorelin acetate (leuprolide acetate) in female rats after subcutaneous (sc) injection of 3-month release injectable and biodegradable microspheres were investigated. After sc injection, the mic
Autor:
Jukka Gynther, Tapio Nevalainen, Jarkko Rautio, Tomi Järvinen, Hannu Taipale, Jouko Vepsäläinen
Publikováno v:
Journal of pharmaceutical sciences. 87(12)
A series of acyloxyalkyl esters of ketoprofen and naproxen were synthesized and investigated as topical prodrugs with the aim of improving the dermal delivery of the drugs. In addition, some hydroxyalkyl esters of ketoprofen and naproxen were synthes
Publikováno v:
Journal of pharmaceutical sciences. 84(3)
The plasma levels of phenytoin after oral administration of phenytoin and phenytoin 2-monoglyceride, a phenytoin prodrug, to rats were determined by gas chromatography. Compared to the application of the parent drug, administration of the prodrug res
Publikováno v:
Journal of Pharmaceutical Sciences. 71:767-771
The technical feasibility of utilizing tampons as a drug delivery system for prolonged intravaginal drug administrations was studied. Several commercially available brands of tampons were examined. The methodology for the incorporation of various dos
Autor:
Joseph Adir, William H. Barr
Publikováno v:
Journal of Pharmaceutical Sciences. 66:1000-1004
The effect of sleep on the bioavailability of tetracycline was studied using 250-mg tetracycline hydrochloride capsules from two commercial sources. One capsule of each brand was given to each of 12 healthy volunteers on two separate occasions. On on