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Autor:
Ronald Schilderink, Maria Vertzoni, Christina Pentafragka, Irena Tomaszewska, Susann Bellmann, Christos Reppas, Mans Minekus, Mark McAllister
Publikováno v:
Journal of Pharmaceutical Sciences. 111:197-205
We evaluated the environment in TIM-1 luminal compartments using paracetamol and danazol solutions and suspensions and the fed state configuration. Data were compared with recently published data in healthy adults. TIM-1 experiments were performed wi
Autor:
Raj K.S. Badhan, He Yu
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3507-3519
Gefitinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, is used to treat non-small-cell lung cancer (NSCLC). Lung cancer rates are high in China and are expected to increase over the next decade. CYP 2D6 inter
Autor:
Craig R. Lee, Craig Sykes, Angela D. M. Kashuba, John K. Fallon, Rebecca J.B. Rementer, Melina M. Malinen, Kim L. R. Brouwer, Amanda P. Schauer, Merrie Mosedale, Paul B. Watkins, Philip C. Smith, Natasha Kulick, Raju Khatri, Kim A. Boggess
Publikováno v:
J Pharm Sci
Pregnancy-related hormones (PRH) have emerged as key regulators of hepatic cytochrome P450 (CYP) enzyme expression and function. The impact of PRH on protein levels of CYP3A4 and other key CYP enzymes, and the metabolism of nifedipine (a CYP3A4 subst
Autor:
Zhiyuan Ma, Hui Zhou, Huidi Jiang, Wang Wei, Xi Yang, Su Zeng, Nengming Lin, Ting Jiang, Shuanghui Lu
Publikováno v:
Journal of Pharmaceutical Sciences. 109:1811-1818
Entecavir (ETV) is a first-line antiviral drug against the hepatitis B virus. This study was designed to investigate whether ETV pharmacokinetics changes during pregnancy and the underlying mechanism. The results showed that ETV exposure in plasma wa
Autor:
Jing-song Mu, Chun-hui Du, Hong Zhu, Qing-guo Zhao, Yan-hong Wang, Qiu-xia Ren, Xingang Li, Jing-feng Bi, Peng Lv
Publikováno v:
Journal of Pharmaceutical Sciences. 108:3923-3931
Because voriconazole metabolism is highly influenced by liver function, the dose regimen of voriconazole should be carefully assessed in patients with liver cirrhosis. We aimed to identify significant factors associated with plasma concentrations. Bl
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2756-2764
The present study examined the significance of enterohepatic circulation and the effect of rifampicin [an inhibitor of organic anion-transporting polypeptide 1B (OATP1B)] on the plasma concentrations of bile acid-O-sulfates (glycochenodeoxycholate-O-
Publikováno v:
Journal of pharmaceutical sciences. 110(8)
Pegylated liposomal doxorubicin (PLD) is widely utilised in cancer chemotherapy, but exhibits large inter-individual pharmacokinetic variability and sex differences in plasma clearance. Population pharmacokinetic modelling has suggested PLD plasma cl
Autor:
John R. Ussher, Zaid H. Maayah, Dion R. Brocks, Ayman O.S. El-Kadi, Hamdah M. Al Nebaihi, Rami Al Batran
Publikováno v:
Journal of pharmaceutical sciences. 109(2)
The effects of a high-fat diet on mRNA and protein of cytochrome P450 (CYP) enzymes in rats and mice and its impact on lidocaine deethylation to its main active metabolite, monoethylglycinexylidide (MEGX), in rats were investigated. The effect of a c
Publikováno v:
Journal of Pharmaceutical Sciences. 106:3402-3409
Tobramycin inhalation solution given as a twice daily inhalation of nebulized aerosols of 300 mg is approved for the treatment of Pseudomonas aeruginosa infection in cystic fibrosis patients over 6 years of age. To investigate tobramycin pharmacokine
Publikováno v:
Journal of Pharmaceutical Sciences. 106:2899-2903
Crizotinib, a tyrosine kinase inhibitor, exhibits some cases of an increase in serum creatinine levels. Creatinine is excreted by not only glomerular filtration but also active secretion by organic cation transporters such as organic cation transport