Zobrazeno 1 - 10
of 66
pro vyhledávání: ''
Publikováno v:
Journal of Pharmaceutical Sciences. 111:417-431
This work aimed to develop a new efficient approach for safe treatment of psoriasis. To achieve that, resveratrol-loaded spanlastics(F1-F12) were prepared and evaluated by complete in vitro characterization. The two optimal formulations (F10 and F11)
Publikováno v:
Journal of Pharmaceutical Sciences. 111:517-528
Background Early assessment of pH-dependent drug-drug-interactions (DDIs) for salts of poorly soluble weakly acidic compounds offers various advantages for patient safety, the pharmaceutical industry, and regulatory bodies. Biorelevant media and test
Publikováno v:
Journal of Pharmaceutical Sciences. 109:3471-3479
The physiological pH changes and peristalsis activities in gastrointestinal (GI) tract have big impact on the dissolution of oral drug products, when those oral drug products include APIs with pH-dependent solubility. It is well documented that predi
Publikováno v:
Journal of Pharmaceutical Sciences. 109:2173-2179
Drug release plays a critical role in defining bioavailability for an extended release solid oral drug products and predictive dissolution tests are desired to establish clinically relevant quality standards for batch release. The objective of this s
Autor:
Jesper Kabel, Kristina Öbrink-Hansen, Mats Bue, Maiken Stilling, Mikkel Tøttrup, Maja B. Thomassen, Kjeld Søballe, Pelle Hanberg
Publikováno v:
Hanberg, P, Bue, M, Öbrink-Hansen, K, Kabel, J, Thomassen, M, Tøttrup, M, Søballe, K & Stilling, M 2020, ' Simultaneous retrodialysis by drug for cefuroxime using meropenem as an internal standard : A microdialysis validation study ', Journal of Pharmaceutical Sciences, vol. 109, no. 3, pp. 1373-1379 . https://doi.org/10.1016/j.xphs.2019.11.014
Microdialysis is a valuable pharmacokinetic tool for obtaining samples of drug concentrations from tissues of interest. When an absolute tissue concentration is needed, a calibration of the microdialysis catheter is required. The use of an internal s
Autor:
Alla Verlinsky, Nathan H. Joh, Shawn Cao, Nancy Jiao, Vibha Jawa, Lisa Thomas, Marisa K. Joubert, Twinkle R. Christian, Linda O. Narhi, Nilo Allotta
Publikováno v:
Journal of Pharmaceutical Sciences. 109:845-853
Silicone oil is a lubricant for prefilled syringes (PFS), a common primary container for biotherapeutics. Silicone oil particles (SiOP) shed from PFS are a concern for patients due to their potential for increased immunogenicity and therefore also of
Autor:
Masato Kaneko, Tero Jalkanen, Shunji Matsuki, Joachim Höchel, Rüdiger Nave, Christine Talling
Publikováno v:
Journal of Pharmaceutical Sciences. 107:1020-1027
Intravaginal rings (IVRs) are an option for continuous administration of drugs in women. However, a considerable amount of excess drug often remains in the ring upon removal. The current study focuses on comparing 2 IVRs releasing levonorgestrel (LNG
Autor:
Mariane de Cássia Lima Dante, Marilisa Guimarães Lara, Márcia Carvalho de Abreu Fantini, Maria Bernadete Riemma Pierre, Fabíola Silva Garcia Praça, Lívia Neves Borgheti-Cardoso, Wanessa Silva Garcia Medina
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Celecoxib (CXB) is a widely used anti-inflammatory drug that also acts as a chemopreventive agent against several types of cancer, including skin cancer. As the long-term oral administration of CXB has been associated with severe side effects, the sk
Autor:
Jiaqiu Xu, Jiayu Wen, Xiaojie Zhu, Xiaoyu Lu, Di Zhao, Xijing Chen, Yang Lu, Yue Yang, Ning Li, Qi Liu
Publikováno v:
Journal of pharmaceutical sciences. 108(10)
Vincristine (VCR) has been used in the treatment of lung cancer. To improve its efficacy, the designs of elevating lung exposure to drug and decreasing the clearance with extended time were brought out. Pulmonary delivery is regarded as a good choice
Autor:
Dongjuan Yang, Mingshi Yang, Xiyan Wang, Shan Gao, Qi Wang, Yan Fang, Kai Shi, Xuechao Jin, Xiaojie Lin
Publikováno v:
Journal of pharmaceutical sciences. 108(9)
Gastrointestinal responsive polymeric nanospheres (NPs) based on hydroxypropyl methylcellulose phthalate were prepared using spontaneous emulsification solvent diffusion method for improved oral administration of insulin. The NPs prepared under optim