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Autor:
Ronald Schilderink, Maria Vertzoni, Christina Pentafragka, Irena Tomaszewska, Susann Bellmann, Christos Reppas, Mans Minekus, Mark McAllister
Publikováno v:
Journal of Pharmaceutical Sciences. 111:197-205
We evaluated the environment in TIM-1 luminal compartments using paracetamol and danazol solutions and suspensions and the fed state configuration. Data were compared with recently published data in healthy adults. TIM-1 experiments were performed wi
Autor:
Craig R. Lee, Craig Sykes, Angela D. M. Kashuba, John K. Fallon, Rebecca J.B. Rementer, Melina M. Malinen, Kim L. R. Brouwer, Amanda P. Schauer, Merrie Mosedale, Paul B. Watkins, Philip C. Smith, Natasha Kulick, Raju Khatri, Kim A. Boggess
Publikováno v:
J Pharm Sci
Pregnancy-related hormones (PRH) have emerged as key regulators of hepatic cytochrome P450 (CYP) enzyme expression and function. The impact of PRH on protein levels of CYP3A4 and other key CYP enzymes, and the metabolism of nifedipine (a CYP3A4 subst
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2756-2764
The present study examined the significance of enterohepatic circulation and the effect of rifampicin [an inhibitor of organic anion-transporting polypeptide 1B (OATP1B)] on the plasma concentrations of bile acid-O-sulfates (glycochenodeoxycholate-O-
Autor:
John R. Ussher, Zaid H. Maayah, Dion R. Brocks, Ayman O.S. El-Kadi, Hamdah M. Al Nebaihi, Rami Al Batran
Publikováno v:
Journal of pharmaceutical sciences. 109(2)
The effects of a high-fat diet on mRNA and protein of cytochrome P450 (CYP) enzymes in rats and mice and its impact on lidocaine deethylation to its main active metabolite, monoethylglycinexylidide (MEGX), in rats were investigated. The effect of a c
Publikováno v:
Journal of Pharmaceutical Sciences. 106:2899-2903
Crizotinib, a tyrosine kinase inhibitor, exhibits some cases of an increase in serum creatinine levels. Creatinine is excreted by not only glomerular filtration but also active secretion by organic cation transporters such as organic cation transport
Autor:
Chong Wang, Zhihao Liu, Kexin Liu, Huijun Sun, Jian Cang, Changyuan Wang, Xiaokui Huo, Qiang Meng, Pengyuan Sun
Publikováno v:
Journal of Pharmaceutical Sciences. 106:2515-2523
Cilostazol undergoes extensive liver metabolism. However, the transporter-mediated hepatic disposition of cilostazol remains unknown. The present study was performed to investigate the hepatic uptake and biliary excretion of cilostazol and its metabo
Publikováno v:
Journal of Pharmaceutical Sciences. 106:961-967
In this study, we evaluated the effect of coadministered metformin on the biliary excretion and liver concentration of atorvastatin. To investigate the inhibitory effect of metformin on biliary efflux transporters, the transport of atorvastatin in MD
Autor:
Takuo Ogihara, Kaori Morimoto, Taichi Ohmachi, Kiko Ichiba, Yoko Idota, Masahiko Kanagawa, Hiroki Kamioka, Takumi Tomono, Yasuko Hatano, Kentaro Yano, Hiroshi Arakawa
Publikováno v:
Journal of Pharmaceutical Sciences. 105:339-342
We investigated the influence of sweet and umami (savory) tastants on the intestinal absorption of cephalexin (CEX), a substrate of peptide transporter 1 (PEPT1, SLC15A1) in rats. After oral administration of glucose or mannitol to rats, CEX was admi
Autor:
Dion R. Brocks, Marwa Al-Agili, Ali Abdussalam, Patrick R. Mayo, Raniah Q. Gabr, Hamdah M. Al Nebaihi
Publikováno v:
Journal of pharmaceutical sciences. 107(11)
The metabolism and biodistribution of the antiarrhythmic drug amiodarone (AM) was assessed in male Sprague-Dawley rats given either normal chow or high-fat and high-fructose diets for 14 weeks. After the feeding period, microsomes were prepared from
Publikováno v:
Journal of pharmaceutical sciences. 106(9)
The importance of multidrug resistance-associated protein 4 (Mrp4/Abcc4) in limiting the penetration of Mrp4 substrate compounds into the central nervous system across the blood-brain barrier was investigated using Mrp4-/- mice. Significant adenosine