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Autor:
Ronald Schilderink, Maria Vertzoni, Christina Pentafragka, Irena Tomaszewska, Susann Bellmann, Christos Reppas, Mans Minekus, Mark McAllister
Publikováno v:
Journal of Pharmaceutical Sciences. 111:197-205
We evaluated the environment in TIM-1 luminal compartments using paracetamol and danazol solutions and suspensions and the fed state configuration. Data were compared with recently published data in healthy adults. TIM-1 experiments were performed wi
Publikováno v:
Journal of Pharmaceutical Sciences. 111:82-87
Drug-drug cocrystals, which can regulate physicochemical properties of individual drugs and might produce synergistic therapeutic effects, have drawn growing interest in the pharmaceutical industry. In this study, a novel drug-drug (1:1) cocrystal hy
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3464-3470
The improvement effect of the combined use of spermine (SPM), a polyamine, with sodium taurocholate (STC) on the pulmonary drug absorption was investigated utilizing poorly absorbable drugs with various molecular sizes in rats. The pulmonary absorpti
Autor:
Dyenefer P. Fonseca, Maíra P. Ferreira, Fabiana T. M. C. Vicentini, Érica Benassi-Zanqueta, Vinícius Pedrazzi, Amanda F. Silva-Alvarez, Tania Ueda-Nakamura, Thalita Zago Oliveira, Ana Clara Wada de Carvalho, Osvaldo de Freitas
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3450-3456
Mucocutaneous infections caused by Herpes simplex virus (HSV-1 and HSV-2) are characterized by the appearance of vesicles that cause pain and embarrassment to the carrier. The standard treatment is based on the use of antivirals in gels or ointments,
Autor:
Raj K.S. Badhan, He Yu
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3507-3519
Gefitinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, is used to treat non-small-cell lung cancer (NSCLC). Lung cancer rates are high in China and are expected to increase over the next decade. CYP 2D6 inter
Autor:
Susanna Edith Medellín-Garibay, Victoria Lima-Rogel, Silvia Romano-Moreno, María del Carmen Romero-Méndez, Tania Correa-López, Ingrid Kühn-Córdova, Leticia Olguin-Mexquitic, Melissa Romano-Aguilar
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3520-3526
Meropenem pharmacokinetics in neonates exhibits large interindividual variability due to developmental changes occurring during the first month of life. The objective was to characterize meropenem pharmacokinetics through a population approach to det
Autor:
Katsuhisa Inoue, Tomoko Yamaguchi, Yoshiharu Deguchi, Kenji Kawabata, Tatsuki Mochizuki, Toshiki Kurosawa, Yuma Tega, Hiroyuki Kusuhara, Daiki Sako, Naoki Ito
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3484-3490
The likelihood of reoccurrence of acute lymphoblastic leukemia is influenced by the cerebral concentration of the therapeutic agent 6-mercaptopurine (6-MP) during treatment. Therefore, it is important to understand the blood-brain barrier (BBB) trans
Autor:
Liangxiao Wang, Chunjie Sha, Yawen Yu, Liuxiang Chu, Kaoxiang Sun, Aiping Wang, Ronglin Kan, Junping Han, Xinran Xi
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3431-3438
Temozolomide is a first-line therapeutic drug for glioblastoma (GBM), and it has a low solubility, short biological half-life, and resistance to drug limits in clinical applications. Therefore, it is necessary to find more effective anti-tumor drugs
Autor:
Mehmet Salih Deveci, Mete Toptaş, Umut Can Oz, Burcu Devrim, Elif Ünsal, Asuman Bozkir, Hasan Bilgili, Berrin Küçüktürkmen, Ongun Mehmet Saka
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3200-3207
In recent years, biomaterial-based treatments, also called guided bone regeneration (GBR), which aim to establish a bone regeneration site and prevent the migration of gingival connective tissue and / or peripheral epithelium through the defective ar
Publikováno v:
Journal of Pharmaceutical Sciences. 110:2946-2954
Glioma-targeted drug delivery is a hugely challenging task because of the multibarrier in the brain. In this study, we report a magnetic T7 peptide&AS1411 aptamer-modified microemulsion for triple glioma-targeted delivery of shikonin and docetaxel (F