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Publikováno v:
JOURNAL OF NEUROSCIENCE RESEARCH
Dopamine signaling in nucleus accumbens (NAc) is modulated by γ-aminobutyric acid (GABA), acting through GABA-A and GABA-B receptors: dysregulation of GABAergic control of dopamine function may be important in behavioral deficits in schizophrenia. W
Autor:
Julien Laffaire, Serguei Nabirotchkin, Noelle Callizot, Philippe Rinaudo, Peter Schmitt, Daniel Cohen, Lydie Boussicault, Rodolphe Hajj
Publikováno v:
Journal of Neuroscience Research
There is currently no therapy impacting the course of amyotrophic lateral sclerosis (ALS). The only approved treatments are riluzole and edaravone, but their efficacy is modest and short‐lasting, highlighting the need for innovative therapies. We p
Autor:
Selina Koilraj, Darrell Sawmiller, R. Douglas Shytle, David Rongo, Sadia Afrin Munna, Jun Tan, Glenn W. Currier, Ahsan Habib, Huayan Hou, Cesario V. Borlongan
Publikováno v:
Journal of Neuroscience Research. 97:1066-1080
Alzheimer’s disease (AD) is characterized by progressive decline of cognition and associated neuropsychiatric signs including weight loss, anxiety, depression, agitation, and aggression, which is particularly pronounced in the female gender. Previo
Autor:
Yi-Na Sun, Jian Liu, Lu Yao, Xing Dai, Qian Yang, Yong Wang, Yong Liu, Xinlin Chen, Li Zhang, Wen Xie
Publikováno v:
Journal of Neuroscience Research. 96:1663-1676
Monoamine oxidase B (MAO B) inhibitors, which inhibit dopamine decomposition by antagonizing MAO B activity, are approved and widely used for clinical treatment of Parkinson's disease (PD). Nonetheless, the mechanism of the abnormally increased MAO B
Autor:
Cynthia Moore, Michelle A. Nipper, Deborah A. Finn, Mo Xu, Charles K. Meshul, Jerry K. Bohlen, Carolyn E. Jones, Miranda M. Lim
Publikováno v:
J Neurosci Res
Sleep complaints are an early clinical symptom of neurodegenerative disorders. Patients with Parkinson's disease (PD) experience sleep disruption (SD). The objective of this study was to determine if preexisting, chronic SD leads to a greater loss of
Autor:
Sangeetha Gupta, Uma Sharma, Yogendra Kumar Gupta, Deepti Upadhayay, Naranamangalam R. Jagannathan
Publikováno v:
Journal of Neuroscience Research. 96:1277-1293
Oxidative stress and inflammation are implicated as cardinal mechanisms of neuronal death following stroke. In the present study citalopram (Cit) was investigated in a 2 h middle cerebral artery occlusion (MCAo) model of stroke in male Wistar rats. P
Autor:
Naveen Sharma, Choon-Gon Jang, Nam-Hun Kim, Ji Hoon Jeong, Huynh Nhu Mai, Eun Hee Cho, Toshitaka Nabeshima, Bao Trong Nguyen, Hyoung-Chun Kim, Phuong Tram Nguyen, Eun-Joo Shin, Yu Jeung Lee
Publikováno v:
Journal of Neuroscience Research. 96:1294-1310
We have previously demonstrated that repeated treatment with methamphetamine (MA) results in a recognition memory impairment via upregulation of protein kinase C (PKC) δ and downregulation of the glutathione peroxidase-1 (GPx-1)-dependent antioxidan
Autor:
Anwesha Banerjee, Gonzalo Flores, Michael P. Kilgard, María Elena Bringas, Roberto Cuevas-Olguin, Swagata Roychowdhury, Eric Esquivel-Rendon, Francisco Garcia-Oscos, Marco Atzori
Publikováno v:
Journal of Neuroscience Research. 95:2456-2468
Autism spectrum disorder (ASD) is a syndrome of diverse neuropsychiatric diseases of growing incidence characterized by repetitive conduct and impaired social behavior and communication for which effective pharmacological treatment is still unavailab
Publikováno v:
Journal of Neuroscience Research. 95:1776-1785
This study aimed to determine the potential systemic and local anti-nociceptive effects of simvastatin (SIM) and the possible role of peroxisome proliferator-activated receptor gamma (PPARγ) and nitric oxide (NO) pathways using a formalin assay in r
Publikováno v:
Journal of Neuroscience Research. 95:1917-1926
Traumatic brain injury (TBI) is the leading cause of injury-related death in children, with boys and children under 4 years having particularly poor outcomes. Activation of ATP- and calcium-sensitive (KATP and KCa ) channels produces cerebrovasodilat