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Autor:
Satoshi Matsuoka, Yukari Takeda
Publikováno v:
Journal of Molecular and Cellular Cardiology. 164:42-50
Roles of mitochondria in sinoatrial nodal cells (SANCs) have not been fully clarified. We have previously demonstrated that mitochondrial Ca2+ efflux through the Na+-Ca2+ exchanger, NCXm, modulates sarcoplasmic reticulum (SR) Ca2+ content and automat
Publikováno v:
Journal of Molecular and Cellular Cardiology. 163:133-146
The integrity of the endothelial barrier is required to maintain vascular homeostasis and fluid balance between the circulatory system and surrounding tissues and to prevent the development of vascular disease. However, the origin of the newly develo
Autor:
Johannes Backs, Sebastian Guttzeit
Publikováno v:
Journal of Molecular and Cellular Cardiology. 162:53-61
Epigenetic modifications, such as histone or DNA modifications are key regulators of gene transcription and changes are often associated with maladaptive processes underlying cardiovascular disease. Epigenetic regulators therefore likely play a cruci
Publikováno v:
J Mol Cell Cardiol
For such a thin tissue, the aortic valve possesses an exquisitely complex, multi-layered extracellular matrix (ECM), and disruptions to this structure constitute one of the earliest hallmarks of fibrocalcific aortic valve disease (CAVD). The native v
Autor:
Jussara M. do Carmo, Elizabeth R. Flynn, Sydney P. Moak, Alexandre A. da Silva, John E. Hall, Nikaela M. Aitken, Ana C M Omoto, Xuan Li, Alan J. Mouton, Zhen Wang
Publikováno v:
J Mol Cell Cardiol
Myocardial infarction (MI) is one of the leading causes of mortality and cardiovascular disease worldwide. MI is characterized by a substantial inflammatory response in the infarcted left ventricle (LV), followed by transition of quiescent fibroblast
Publikováno v:
J Mol Cell Cardiol
We have created a novel in-vitro platform to study reverse remodeling of engineered heart tissue (EHT) after mechanical unloading. EHTs were created by seeding decellularized porcine myocardial sections with a mixture of primary neonatal rat ventricu
Autor:
Boudewijn P.T. Kruithof, Nina Ajmone Marsan, Martin J. Schalij, Marco C. De Ruiter, Vera van de Pol, Tamara Los, Kirsten Lodder, Marie-José Goumans
Publikováno v:
Journal of Molecular and Cellular Cardiology, 156, 95-104. ELSEVIER SCI LTD
Calcific aortic valve disease (CAVD) is a common progressive disease of the aortic valves, for which no medical treatment exists and surgery represents currently the only therapeutic solution. The development of novel pharmacological treatments for C
Autor:
Mohammed Mashali, Bryan A. Whitson, Jae-Hoon Chung, Nancy S. Saad, Eric J. Schultz, Ahmet Kilic, Nahush A. Mokadam, Mohammad T. Elnakish, Amanda W. Huang, Farbod Fazlollahi, Salome A. Kiduko, Brit L. Martin, Jason D. Murray, Paul M.L. Janssen, Kyra K. Peczkowski, Austin Hare, Peter J. Mohler, Benjamin D. Canan, Courtney M. Campbell, Nima Milani-Nejad
Publikováno v:
J Mol Cell Cardiol
Background Heart failure (HF) is associated with highly significant morbidity, mortality, and health care costs. Despite the significant advances in therapies and prevention, HF remains associated with poor clinical outcomes. Understanding the contra
Autor:
Robert M. Graham, Andrea Y. Chan, Jianxin Wu, Xenia Kaidonis, Siiri E. Iismaa, Scott H. Kesteven, Michael P. Feneley, Stephen F. Vatner, Wenxing Niu
Publikováno v:
Journal of Molecular and Cellular Cardiology. 155:78-87
The 'fight or flight' response to physiological stress involves sympathetic nervous system activation, catecholamine release and adrenergic receptor stimulation. In the heart, this induces positive inotropy, previously attributed to the β1-adrenergi
Autor:
Corrado Poggesi, Michael Regnier, Jennifer Davis, Momcilo Prodanovic, Michael A. Geeves, Joseph D. Powers, Srboljub M. Mijailovich
Publikováno v:
Journal of Molecular and Cellular Cardiology
J Mol Cell Cardiol
J Mol Cell Cardiol
One of the complexities of understanding the pathology of familial forms of cardiac diseases is the level of mutation incorporation in sarcomeres. Computational models of the sarcomere that are spatially explicit offer an approach to study aspects of