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Publikováno v:
Journal of Clinical Pathology. 70:1084-1087
Heparin can induce the formation of antibodies against a heparin complex with a platelet factor 4 (PF4), leading to platelet activation and the development of heparin-induced thrombocytopaenia (HIT). Because screening ELISA does not discriminate betw
Autor:
Diane Zlotnik, Bernard Le Bonniec, Anne-Céline Martin, Leyla Calmette, Pascale Gaussem, Isabelle Gouin-Thibault, Anne Godier, Christilla Bachelot-Loza
Publikováno v:
Journal of Clinical Pathology. 70:733-739
AimManagement of ticagrelor-induced bleeding is challenging as platelet transfusion is ineffective. An effective strategy is needed. This study aimed to investigatein vitrothe efficacy of four haemostatic drugs (HDs), namely recombinant activated fac
Autor:
Giovanni Ciuffetti, Rita Lombardini, Matteo Pirro, Leonella Pasqualini, Elmo Mannarino, P Dragani
Publikováno v:
Journal of Clinical Pathology. 55:946-950
Aims: In humans, little is known about the effects of platelet–leucocyte interactions on blood viscosity and microvascular perfusion. This study tested the hypotheses that (1) activation and interactions between platelets and leucocytes may have an
Autor:
T P Baglin
Publikováno v:
Journal of Clinical Pathology. 54:272-274
Heparin induced thrombocytopenia thrombosis (HIT/T) is associated with a high morbidity and mortality. Diagnosis is essentially clinical and negative results of laboratory assays do not exclude the diagnosis. Treatment involves stopping all heparin i
Publikováno v:
Williams, K J, Bax, R P, Brown, H & Machin, S J 1991, ' Antibiotic treatment and associated prolonged prothrombin time ', Journal of Clinical Pathology, vol. 44, no. 9, pp. 738-41 .
The incidence and type of pathology causing a prolonged prothrombin time and clinical bleeding episodes were assessed in a multicentre study of 1109 patients receiving cefotetan, a N-methyl-thiotetrazole (NMTT), or equivalent antibiotics. There was n
Publikováno v:
Journal of Clinical Pathology. 47:159-161
AIMS--To assess whether r-HuEPO (recombinant human erythropoietin) has any effect on thrombopoiesis in patients with chronic renal failure. METHODS--This was a retrospective study of 78 patients with chronic renal failure undergoing either haemodialy
Publikováno v:
Journal of Clinical Pathology. 43:476-478
Fifty seven patients with schistosomiasis of the liver and spleen in both the compensated and decompensated states and 15 non-bilharzial subjects were studied. Fibrinogen, plasminogen, fibrinogen/fibrin degradation products, alpha 2-macroglobulin, an
Autor:
Dimitri P. Mikhailidis, J.Y. Jeremy, G.R.V. Hughes, Ronald A. Hutton, Paresh Dandona, R M Bernstein
Publikováno v:
Journal of Clinical Pathology. 37:182-187
Platelet function was studied in 11 patients with Raynaud's syndrome and 11 healthy controls. Platelets obtained from patients with Raynaud's syndrome were significantly more responsive to adrenaline, produced more thromboxane A2, and were resistant
Publikováno v:
Journal of Clinical Pathology. 36:570-573
The presence or absence of venous thrombosis was determined by the technique of autologous 111indium-labelled platelets in 64 patients following reduction and fixation of fractures of the neck of femur. Venous thrombosis was found in 41 (64%) of thes
Publikováno v:
Journal of Clinical Pathology. 36:1382-1386
Platelet concentrates were prepared for in vitro storage in either Fenwal PL-732 or Cutter CLX platelet packs. The units were stored at 22 degrees C for seven days with either horizontal or tumbler agitation. Measurement of pH, hypotonic shock respon