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Synthesis and biological activities study of novel phthalimides and phenylpyrazolo[1,5-a]pyrimidines
Autor:
Jianchun Jiang, Yajing Wang, Cao Yijing, Long Tang, Song Guoqiang, Feng Xiaoqing, Huang Xianfeng, Min Wei
Publikováno v:
Journal of Chemical Research. 45:731-737
Phosphodiesterase II (PDE2) is mainly distributed in brain and heart cells, and it is a potential therapeutic target for the treatment of central nervous system (CNS) diseases such as Alzheimer’s disease. Based on the structure of the existing PDE2