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Publikováno v:
Journal of Cancer Research and Clinical Oncology. 148:565-575
Purpose: NRAS plays a pivotal role in progression of various kinds of somatic malignancies; however, the correlation between NRAS and lung adenocarcinoma is less known. We aim to analyze the prognostic value of NRAS expression in lung adenocarcinoma,
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose Cyclase-associated protein 1 (CAP1) is a ubiquitous protein which regulates actin dynamics. Previous studies have shown that S308 and S310 are the two major phosphorylated sites in human CAP1. In the present study, we aimed to investigate the
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 147:3627-3637
The purpose of our study is to investigate the roles of IL-18 gene variations in bladder cancer development in Thrace population of Turkey. This study was carried out with 103 bladder cancer patients and 81 healthy controls. Genotype distributions of
Autor:
Christian Röder, Sandra Krüger, Christine Halske, Anna Trauzold, Jan-Paul Gundlach, Anna Willms, Franka Maria Schlegel, Holger Kalthoff, Charlotte Hauser, Thomas E. Becker, Christoph Röcken
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose HMGA2 has frequently been found in benign as well as malignant tumors and a significant association between HMGA2 overexpression and poor survival in different malignancies was described. In pancreatic ductal adenocarcinoma (PDAC), nuclear HM
Autor:
Martha A. Zeiger, Zhiyang Liu, Brittany A. McKelvey, Leslie Cope, Christopher B. Umbricht, Yongchun Wang, Lisa M. Rooper
Publikováno v:
J Cancer Res Clin Oncol
BACKGROUND: While molecular testing is a promising strategy for preoperative assessment of cytologically indeterminate thyroid nodules, thyroid fine needle aspiration biopsy (FNA) presents unique challenges for molecular assays, including contaminati
Autor:
Robert H. Reid, Mina Swiha, Daniele Wiseman, Alireza Khatami, Amol Mujoomdar, Golmehr Sistani, Rami M Abazid, Jonathan Romsa, Duncan E. K. Sutherland, David Laidley
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose 177Lu-Dotatate is an emerging treatment modality for patients with unresectable or metastatic well-differentiated NETs. This study examines survival predictors in patients who received 177Lu-Dotatate. Methods A retrospective single-center rev
Autor:
Georg Hutarew, Barbara Zellinger, Peter A Winkler, Dorothee Hölzl, Hans U Schlicker, Karl Sotlar, Theo Kraus, Christoph Schwartz
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose Gliomas are the most frequent primary brain tumors of adults. Despite intensive research, there are still no targeted therapies available. Here, we performed an integrated analysis of glioma and programmed cell death ligand 1 (PD-L1) in 90 sa
Autor:
Thomas Karn, Friederike Hoellen, Uwe Holtrich, Stefan Kommoss, Achim Rody, Heidrun Gevensleben, David G. Huntsman, Z Drosos, Michael S. Anglesio, M Graeser-Mayer, Lars Hanker, G Gitas, Ahmed El-Balat
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose Sphingosine-kinase-1 (SPHK1) is a key enzyme of sphingolipid metabolism which is involved in ovarian cancer pathogenesis, progression and mechanisms of drug resistance. It is overexpressed in a variety of cancer subtypes. We investigated SPHK
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 146:2851-2859
TP53/EGFR co-mutation has been reported to affect the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in lung adenocarcinoma (LUAD). However, its impact on survival is unclear. In this analysis, we explored the p
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose Coronavirus disease 2019 (COVID-19) tends to affect multiple organs and induce abnormal laboratory parameters. We designed this study to investigate the association between carcinoembryonic antigen (CEA) elevation and SARS-CoV-2 infection. Me