Zobrazeno 1 - 10
of 263
pro vyhledávání: '"John S"'
Autor:
Maryam Alhumaidi, Lea-Marie Nentwig, Hadiar Rahman, Lutz Schmitt, Andrew Rudrow, Andrzej Harris, Cierra Dillon, Lucas Restrepo, Erwin Lamping, Nidhi Arya, Suresh V. Ambudkar, John S. Choy, John Golin
Publikováno v:
Journal of Biological Chemistry. 298:102689
ATP-binding cassette (ABC) multidrug transporters are large, polytopic membrane proteins that exhibit astonishing promiscuity for their transport substrates. These transporters unidirectionally efflux thousands of structurally and functionally distin
Autor:
Arne Ittner, Glenda M. Halliday, Mian Bi, John R. Hodges, Matthew C. Kiernan, Astrid F. Feiten, Michael Kassiou, Jillian J. Kril, Yazi D. Ke, Gabriella Chan, Clement T. Loy, Julius Muller, Olivier Piguet, Lars M. Ittner, Greg T. Sutherland, Carol G. Au, John S. Mattick, Magdalena Przybyla, Kristie Stefanoska, Emmanuel Prikas
Publikováno v:
J Biol Chem
The microtubule-associated protein tau undergoes aberrant modification resulting in insoluble brain deposits in various neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy, and corticobasal degeneration
Autor:
Anna C. Salzberg, Premal Shah, John S. Favate, William P. Miller, Scot R. Kimball, Sadie K. Dierschke, Michael D. Dennis, Leonard S. Jefferson, Yuka Imamura Kawasawa
Publikováno v:
Journal of Biological Chemistry. 294:5508-5520
Diabetes promotes the posttranslational modification of proteins by O-linked addition of GlcNAc (O-GlcNAcylation) to Ser/Thr residues of proteins and thereby contributes to diabetic complications. In the retina of diabetic mice, the repressor of mRNA
Autor:
Xinming Cai, Zinger Yang, John S. Reece-Hoyes, Edmund Harrington, John Alford, Tim Schuhmann, Luis Llamas, Rob Maher, Alicia Lindeman, Stephen M. Canham, Irina Alimov, Nadire Cochran, Carsten Russ, Suchithra Menon, Gregory R. Hoffman, Qiong Wang, John Concannon
Publikováno v:
Journal of Biological Chemistry. 294:3359-3366
Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut microbiota. The conversion of bile acids by the gut microbiome is now recognized as a factor
Autor:
Lisa Garrett, Mary M. McKenna, John S. Gibson, Suilan Zheng, Anke Hannemann, Nathan A. Krump, Yen Hsing Li, Philip S. Low, David M. Bodine
Publikováno v:
Journal of Biological Chemistry. 294:2519-2528
Many erythrocyte processes and pathways, including glycolysis, the pentose phosphate pathway (PPP), KCl cotransport, ATP release, Na(+)/K(+)-ATPase activity, ankyrin–band 3 interactions, and nitric oxide (NO) release, are regulated by changes in O(
Autor:
Matthew C. Madison, Dev K. Chatterjee, David B. Corry, Ed Felix, Atul Varadhachary, John S. McMurray, Melissa M. Singh, Joel M. Sederstrom, Brandon Saxton, Pietro Morlacchi, Garbo Mak, Cameron T. Landers, Pijus K. Mandal, Brian E. Gilbert, J. Morgan Knight, Evan Li
Publikováno v:
Journal of Biological Chemistry. 293:10026-10040
Asthma is a chronic inflammatory disease of the lungs and airways and one of the most burdensome of all chronic maladies. Previous studies have established that expression of experimental and human asthma requires the IL-4/IL-13/IL-4 receptor α (IL-
Publikováno v:
The Journal of biological chemistry, vol 293, iss 6
The Journal of biological chemistry, vol 293, iss 18
The Journal of biological chemistry, vol 293, iss 18
Proprotein convertase subtilisin/kexin type 9 (PCSK9) down-regulates the low-density lipoprotein (LDL) receptor, elevating LDL cholesterol and accelerating atherosclerotic heart disease, making it a promising cardiovascular drug target. To achieve it
Autor:
John S. Millar, Swapnil V. Shewale, Raymond N. Sequeira, Daniel J. Rader, Minal B. Mehta, Nicholas J. Hand
Publikováno v:
Journal of Biological Chemistry. 292:10444-10454
Maintenance of whole-body glucose homeostasis is critical to glycemic function. Genetic variants mapping to chromosome 8p23.1 in genome-wide association studies have been linked to glycemic traits in humans. The gene of known function closest to the
Autor:
Lorenza Favrot, Adel A. Malek, Olivia Vergnolle, John S. Blanchard, Hua Xu, Jo Ann M. Tufariello, William R. Jacobs
Publikováno v:
Journal of Biological Chemistry. 291:22315-22326
Iron is an essential element for life, but its soluble form is scarce in the environment and is rarer in the human body. Mtb (Mycobacterium tuberculosis) produces two aryl-capped siderophores, mycobactin (MBT) and carboxymycobactin (cMBT), to chelate
Autor:
Kathleen M. Azzam, Prashant Rai, Jennifer H. Madenspacher, Anders M. Näär, Lihua Lai, Jim J. Aloor, Michael B. Fessler, Julie M. Lowe, Wan Chi Lin, John S. Parks, Kristin A. Gabor
Publikováno v:
Journal of Biological Chemistry. 291:19651-19660
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by promoting degradation and/or repressing translation of specific target mRNAs. Several miRNAs have been identified that regulate the amplitude of the innate immune response