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Autor:
Eike Gallmeier, Ana Sofia Cardoso Martins, Kirsten Lauber, Claus Belka, Lars H. Lindner, Dominique Harnicek, Roland Kanaar, Simone Mörtl, Yang Guo, Wolfgang Hiddemann, Roman Hennel, Ulrich Mansmann, Rolf D. Issels, Tomas Hucl, Eric Kampmann
Publikováno v:
International Journal of Cancer. 139:467-479
The tetrahydroisoquinoline trabectedin is a marine compound with approved activity against human soft-tissue sarcoma. It exerts antiproliferative activity mainly by specific binding to the DNA and inducing DNA double-strand breaks (DSB). As homologou
Autor:
Miriam R. Anver, Frances P. Noonan, Faith M. Strickland, Agnieszka Wolnicka-Glubisz, Edward C. De Fabo, Albert R. Wielgus, Glenn Merlino
Publikováno v:
International Journal of Cancer. 136:752-760
Melanocortin 1 receptor (MC1R) signaling stimulates black eumelanin production through a cAMP-dependent pathway. MC1R polymorphisms can impair this process, resulting in a predominance of red phaeomelanin. The red hair, fair skin and UV sensitive phe
Autor:
Ralf Schreck, Ulf R. Rapp
Publikováno v:
International Journal of Cancer. 119:2261-2271
Raf kinase signaling has been thoroughly investigated over the last 20 years. A-Raf, B-Raf and C-Raf, the 3 mammalian members of the Raf family, are involved in a variety of cellular processes such as growth, proliferation, survival, differentiation
Autor:
Albert Altés, Eugenio Marcuello, Angeles César, Elisabeth del Río, Montserrat Baiget, Anna Menoyo
Publikováno v:
International Journal of Cancer. 112:733-737
Thymidylate synthase (TS) is the primary target of 5-fluorouracil (5-FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5-FU-based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the se
Publikováno v:
International Journal of Cancer. 72:700-705
Development of anti-estrogen resistance limits the benefit of endocrine therapy of breast cancer. The mechanistic basis for resistance to the anti-estrogen tamoxifen may involve (epi)genetic alterations within tumor cells. We have initiated a random
Publikováno v:
International Journal of Cancer. 65:426-431
Testicular germ cell tumours (TGCT) are cured in over 80% of patients by using combination chemotherapy. However, the mechanism regulating this sensitivity has not been defined. Because cells derived from patients with DNA repair syndromes are simila
Publikováno v:
International Journal of Cancer. 65:506-512
The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes alkyl groups from the O6 position of guanine in DNA and thus may protect cells against genotoxic effects of agents inducing this lesion. To analyze quantitatively the level
Publikováno v:
International Journal of Cancer. 65:365-371
To investigate the mechanism of resistance to an antineoplastic natural product homoharringtonine (HHT) in leukemic cells, we have established 5 sub-lines of human myeloid leukemia K562 cells, designated as K-H30, K-H100, K-H200, K-H300 and K-H400, w
Autor:
Mario de Luise, John D. Parkin, Shelagh E. L. Mirski, Phillip Kantharidis, Vickie Vrazas, Gabrielle Nadalin, Susan P.C. Cole, Xiu F. Hu, Lynda J. Campbell, John Zalcberg, Dominic M. Wall
Publikováno v:
International Journal of Cancer. 57:522-528
Separate mechanisms underlying the multidrug resistant (MDR) phenotype were identified in 2 independent approaches to select tumour cells resistant to low concentrations of doxorubicin (Dox) from the sensitive T cell leukemia cell line CCRF-CEM. The
Autor:
Bridget T. Hill, Sharon A. Shellard, Sally L. Davies, Mary K. Danks, Louise K. Hosking, Richard D. H. Whelan, Ian D. Hickson
Publikováno v:
International Journal of Cancer. 57:259-267
Mechanisms of resistance to VP-16 were monitored in a series of sublines of the human testicular teratoma cell line (SuSa) derived following exposure either to fractionated X-irradiation (DXR-10) or to VP-16 using pulsed 24-hr exposures (VP 10) or co