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Autor:
Ho Sup Lee, Yeon-Joo Song, Won Sik Lee, Jae-Cheol Jo, Min-Jung Kim, Da Jung Kim, Lee Chun Park, Ho-Jin Shin, Young Rok Do, Sung Yong Oh, Jee-Yeong Jeong
Publikováno v:
International Journal of Cancer. 145:2459-2467
Erythropoiesis-stimulating agents (ESAs), such as erythropoietin (EPO) and darbepoetin, may alleviate anemia in diffuse large B-cell lymphoma (DLBCL) patients. However, many cancer cells express EPO receptors (EPOR), through which exogenously adminis
Autor:
Alexandra Kourakli, Meletios A. Dimopoulos, Pavlina Konstantinidou, Georgia Christopoulou, Flora Zagouri, Maria Gavriatopoulou, Eirini Katodritou, Dimitrios Christoulas, Antonis Gerofotis, Efstathios Kastritis, Argiris Symeonidis, Evangelos Terpos, Ioannis Ntanasis-Stathopoulos
Publikováno v:
International Journal of Cancer. 145:559-568
There is limited data regarding the efficacy and safety of lenalidomide, adriamycin and dexamethasone (RAD) combination on newly diagnosed multiple myeloma (NDMM) patients. There is also scarce information about the effect of lenalidomide on bone met
Autor:
Anida Hasanovic, Sara Jung, Laurie Signetti, Felix Beuschlein, Massimo Terzolo, Enzo Lalli, Marco Volante, Ida Rapa, Carmen Ruggiero, Constanze Hantel, Monia Ben Hadj, Isabelle Mus-Veteau
Publikováno v:
International Journal of Cancer. 143:199-211
One of the crucial challenges in the clinical management of cancer is the resistance to chemotherapeutics. We recently demonstrated that the Hedgehog receptor Patched, which is overexpressed in many recurrent and metastatic cancers, is a multidrug tr
Autor:
Ji Won Kim, Seung Woo Chung, Ok Cheol Jeon, Hanul Lee, Young Seok Cho, Seong Who Kim, Seho Kweon, Beom Suk Lee, In San Kim, Sang Yoon Kim, Youngro Byun, Jeong Uk Choi, Gui Chul Kim, Foyez Mahmud
Publikováno v:
International Journal of Cancer. 141:1912-1920
Chemotherapy have commonly been used in maximum tolerated dose to completely eradicate the cancer. However, such treatments often failed due to the complex and dynamic nature of cancer. Therefore, it has been suggested that cancer should be treated a
Autor:
Alexander Zakharov, Andre Kajdacsy-Balla, Jennifer Poirier, Jamie Harris, Monika Pilichowska, Naohiko Ikegaki, Alexander V. Lyubimov, Jeannine M. Coburn, Bill Chiu, Hiroyuki Shimada, David L. Kaplan
Publikováno v:
International Journal of Cancer. 140:726-735
Neuroblastoma is the most common extracranial childhood solid tumor. Treatment of high risk tumors require intense multicycle chemotherapies, resulting in short- and long-term toxicities. Here, we present treatment of an orthotopic neuroblastoma mous
Autor:
Qian He, Ji Na Kong, Somsankar Dasgupta, Stefka D. Spassieva, Gu Zhu, Austin Kim, Guanghu Wang, Michael B. Dinkins, Erhard Bieberich
Publikováno v:
International Journal of Cancer. 137:1610-1620
Many breast cancer cells acquire multidrug resistance (MDR) mediated by ABC transporters such as breast cancer resistance protein (BCRP/ABCG2). Here we show that incubation of human breast cancer MDA-MB-231 cells with farnesoid X receptor antagonist
Publikováno v:
International Journal of Cancer. 137:731-743
Temperature-sensitive vesicles designed by inclusion of leucine zipper peptides within a lipid bilayer (Lp-Peptide hybrids) encapsulating Doxorubicin (DOX) have been reported. Intravenous administration of these constructs prolonged blood circulation
Autor:
Nicholas P. Gannon, Kristina A. Trujillo, Marco Bisoffi, Randi Garcia-Smith, Roger A. Vaughan
Publikováno v:
International Journal of Cancer. 136:E197-E202
Exercise has been shown to reduce risk and improve prognosis of several types of cancers. Irisin is a myokine linked to exercise and lean body mass, which is thought to favorably alter metabolism systemically, potentially providing benefit for metabo
Autor:
Mikko Siurala, Simona Bramante, Markus Vähä-Koskela, Anja Kipar, Siri Tähtinen, Anna Kanerva, Suvi Parviainen, Kilian Guse, Mari Hirvinen, Lotta Vassilev, Vincenzo Cerullo, Akseli Hemminki
Publikováno v:
International Journal of Cancer. 136:945-954
Despite originating from several different tissues, soft-tissue sarcomas (STS) are often grouped together as they share mesenchymal origin and treatment guidelines. Also, with some exceptions, a common denominator is that when the tumor cannot be cur
Autor:
Olaf van Tellingen, Alfred H. Schinkel, Jyoti Naik, Els Wagenaar, Selvi Durmus, Levi C.M. Buil
Publikováno v:
International Journal of Cancer. 135:1700-1710
Organic anion-transporting polypeptides (OATPs) are important drug uptake transporters, mediating distribution of substrates to several pharmacokinetically relevant organs. Doxorubicin is a widely used anti-cancer drug extensively studied for its int