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pro vyhledávání: ''
Autor:
Bianca J. Kuhn, Claudia Lohrey, Felix Hoppe-Seyler, Tobias D. Strobel, Karin Hoppe-Seyler, Jeroen Krijgsveld, Julia Bulkescher, Antonia Däschle, Anja L. Herrmann
Publikováno v:
International Journal of Cancer. 149:1137-1149
Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The viral E6/E7 oncogenes maintain the malignant growth of HPV-positive cancer cells. Targeted E6/E7 inhibition results in efficient induction of cellular senescence, which
Autor:
Huili Wang, Loren S. Michel, Richard J. Wong, Vatche Tchekmedyian, Daphna Y. Gelblum, Lara Dunn, Alisa Rybkin, Bhuvanesh Singh, Kenneth K.-S. Ng, Jung Julie Kang, Wanqing Iris Zhi, Marc Cohen, Snehal G. Patel, C. Jillian Tsai, Juliana Eng, Ian Ganly, James Vincent Fetten, Nader Mohammed, Eric J. Sherman, Stephanie Lobaugh, Yao Yu, Alan L. Ho, Luc G. T. Morris, David G. Pfister, Jay O. Boyle, Sean McBride, Anna Lee, Jennifer R. Cracchiolo, Nancy Y. Lee, Ming Fan, Zhigang Zhang, S. Kitpanit, Kaveh Zakeri, Linda Chen, Nadeem Riaz
Publikováno v:
Int J Cancer
High-dose (HD) cisplatin remains the standard of care with chemoradiation for locally advanced oropharyngeal cancer (OPC). Cooperative group trials mandate bolus-HD (100 mg/m2 × 1 day, every 3 weeks) cisplatin administration at the beginning of the
Autor:
Zoran Gatalica, Mina Nikanjam, Donald A. Barkauskas, Jeff Swensen, Razelle Kurzrock, David Arguello
Publikováno v:
International Journal of Cancer
International journal of cancer, vol 146, iss 11
International journal of cancer, vol 146, iss 11
Chemotherapy and checkpoint inhibitor immunotherapies are increasingly used in combinations. We determined associations between the presence of anti‐PD‐1/PD‐L1 therapeutic biomarkers and protein markers of potential chemotherapy response. Data
Publikováno v:
International Journal of Cancer. 147:1474-1484
Replication stress is a common feature of cancer cells. Ataxia telangiectasia-mutated (ATM) and Rad3-related (ATR) signalling, a DNA damage repair (DDR) pathway, is activated by regions of single-stranded DNA (ssDNA) that can arise during replication
Autor:
Jeong Won Jang, Sun Hong Yoo, U Im Chang, Hee Yeon Kim, Seung Kew Yoon, Do Seon Song, Sang Wook Choi, Jong Young Choi, Chang Wook Kim, Sung Won Lee, Kwon Yong Tak, Seok Hwan Kim, Pil Soo Sung, Hae Lim Lee, Jung Hyun Kwon, Myeong Jun Song, Jin Mo Yang, Hee Chul Nam
Publikováno v:
International Journal of Cancer. 147:1970-1978
Controlling adverse events (AEs) through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sorafenib dosing. The aim of this study was to evaluate whether sorafenib dosing could affect treatment outcom
Autor:
Markus Thiemann, Peter E. Huber, Christopher L Heidler, Eva K Roth, Michal Kovac, Beate Amthor, Claudia Blattmann, Gabriele Neu-Yilik, Ramon Lopez Perez, Andreas E. Kulozik
Publikováno v:
International Journal of Cancer
Progress in the systemic control of osteosarcoma has been limited over the past decades thus indicating the urgent clinical need for the development of novel treatment strategies. Therefore, we have recently developed new preclinical models to study
Autor:
Shuntaro Nagai, Maiko Nishibori, Kiyofumi Nitta, Kiyoshi Saeki, Masafumi Nakamura, Oki Sekizawa, Tatsuhiro Ishida, Kinuko Nagayoshi, Takashi Ueki, Tatsuya Manabe, Yoshihiko Sadakari, Yoshinao Oda, Hayato Fujita, Ryo Koba
Publikováno v:
International Journal of Cancer. 146:2498-2509
Oxaliplatin (l-OHP), a platinum-based drug, is a key chemotherapeutic agent for colorectal cancer (CRC), but drug resistance and toxic effects have been major limitations of its use. Synchrotron radiation X-ray fluorescence spectrometry (SR-XRF) is a
Autor:
Carol Wadham, Shiloh Middlemiss, Michelle J. Henderson, Richard B. Lock, Murray D. Norris, Angelika Bongers, Katerina Gurova, Chelsea Mayoh, Mawar Karsa, Andrei V. Gudkov, Angelika Kosciolek, Michelle Haber, Ursula R. Kees, Nickolay Neznanov, Rosemary Sutton, Ali El-Ayoubi, Klaartje Somers
Publikováno v:
International Journal of Cancer. 146:1902-1916
Around 10% of acute leukemias harbor a rearrangement of the MLL/KMT2A gene, and the presence of this translocation results in a highly aggressive, therapy-resistant leukemia subtype with survival rates below 50%. There is a high unmet need to identif
Autor:
Xiang Zeng, Kumuluzi Mulati, Naoki Horikawa, Mana Taki, David G. Hunstman, Kaoru Abiko, Masaki Mandai, Sachiko Kitamura, Budiman Kharma, Ken Yamaguchi, Ryusuke Murakami, Junzo Hamanishi, Noriomi Matsumura, Yuko Hosoe, Tsukasa Baba, Yuka Mise
Publikováno v:
International Journal of Cancer. 145:1635-1647
Uterine serous carcinoma (USC) is a highly aggressive histological subtype of endometrial cancers harboring highly metastatic and chemoresistant features. Our previous study showed that STAT1 is highly expressed in USC and acts as a key molecule that
Autor:
Koji Haratani, Yoshikane Nonagase, Hisato Kawakami, Kazuhiko Nakagawa, Ryoji Kato, Naoki Takegawa, Hidetoshi Hayashi, Osamu Maenishi, Junji Tsurutani, Masayuki Takeda, Kimio Yonesaka
Publikováno v:
International Journal of Cancer. 145:3414-3424
Therapies targeted to human epidermal growth factor receptor 2 (HER2) have proven effective against tumors positive for HER2 amplification, but there is an unmet clinical need for the treatment of tumors that express HER2 protein in the absence of HE