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Autor:
Mariano F. Zacarías-Fluck, Daniel Massó-Vallés, Fabio Giuntini, Íñigo González-Larreategui, Jastrinjan Kaur, Sílvia Casacuberta-Serra, Toni Jauset, Sandra Martínez-Martín, Génesis Martín-Fernández, Erika Serrano del Pozo, Laia Foradada, Judit Grueso, Lara Nonell, Marie-Eve Beaulieu, Jonathan R. Whitfield, Laura Soucek
Publikováno v:
Genes & Development. 37:303-320
MYC's key role in oncogenesis and tumor progression has long been established for most human cancers. In melanoma, its deregulated activity by amplification of 8q24 chromosome or by upstream signaling coming from activating mutations in the RAS/RAF/M
Autor:
Yulia Gonskikh, Julian Stoute, Hui Shen, Krista Budinich, Bianca Pingul, Kollin Schultz, Heidi Elashal, Ronen Marmorstein, Junwei Shi, Kathy Fange Liu
Publikováno v:
Genes & Development. 37:321-335
Several rRNA-modifying enzymes install rRNA modifications while participating in ribosome assembly. Here, we show that 18SrRNA methyltransferase DIMT1 is essential for acute myeloid leukemia (AML) proliferation through a noncatalytic function. We rev
Autor:
Manuel Guthmann, Chen Qian, Irene Gialdini, Tsunetoshi Nakatani, Andreas Ettinger, Tamas Schauer, Igor Kukhtevich, Robert Schneider, Don C. Lamb, Adam Burton, Maria-Elena Torres-Padilla
Publikováno v:
Genes & Development. 37:336-350
The majority of our genome is composed of repeated DNA sequences that assemble into heterochromatin, a highly compacted structure that constrains their mutational potential. How heterochromatin forms during development and how its structure is mainta
Autor:
Tian-Tian Liu, Feiya Ou, Julia A. Belk, Prachi Bagadia, David A. Anderson, Vivek Durai, Winnie Yao, Ansuman T. Satpathy, Theresa L. Murphy, Kenneth M. Murphy
Publikováno v:
Genes & Development. 37:291-302
Individual elements within a superenhancer can act in a cooperative or temporal manner, but the underlying mechanisms remain obscure. We recently identified anIrf8superenhancer, within which different elements act at distinct stages of type 1 classic
Autor:
Guillaume Andrey, Denis Duboule
Publikováno v:
Genes & Development. 37:261-276
Congenital genetic disorders affecting limb morphology in humans and other mammals are particularly well described, due to both their rather high frequencies of occurrence and the ease of their detection when expressed as severe forms. In most cases,
Autor:
Shujuan Song, Zhenyi Su, Ning Kon, Bo Chu, Huan Li, Xuejun Jiang, Jianyuan Luo, Brent R. Stockwell, Wei Gu
Publikováno v:
Genes & Development. 37:204-217
Although it is well established that Huntington's disease (HD) is mainly caused by polyglutamine-expanded mutant huntingtin (mHTT), the molecular mechanism of mHTT-mediated actions is not fully understood. Here, we showed that expression of the N-ter
Autor:
Lisa-Marie Appel, Johannes Benedum, Magdalena Engl, Sebastian Platzer, Alexander Schleiffer, Xué Strobl, Dea Slade
Publikováno v:
Genes & Development. 37:140-170
Since it was first described >20 yr ago, the SPOC domain (Spen paralog and ortholog C-terminal domain) has been identified in many proteins all across eukaryotic species. SPOC-containing proteins regulate gene expression on various levels ranging fro
Autor:
Kelly Mitchell, Samuel A. Sprowls, Sonali Arora, Sajina Shakya, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel E. Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, Jonathan D'Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Eric C. Holland, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia
Publikováno v:
Genes & Development. 37:86-102
Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors driven by populations of cancer stem cells (CSCs). However, few molecular mechanisms critical for CSC population maintenance have been exploited for therapeutic development. We develo
Publikováno v:
Genes & Development. 37:103-118
RNA-directed DNA methylation in plants is guided by 24 nt siRNAs generated in parallel with 23 nt RNAs of unknown function. We show that 23 nt RNAs function as passenger strands during 24 nt siRNA incorporation into AGO4. The 23 nt RNAs are then slic
Publikováno v:
Genes & Development. 37:80-85
Zygotic genome activation has been extensively studied in a variety of systems including flies, frogs, and mammals. However, there is comparatively little known about the precise timings of gene induction during the earliest phases of embryogenesis.