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Autor:
Jing Zhao, Han Xiao, Ping Liang, Ning Jiang, Li Zhang, Shuyue Zheng, Hui Gan, Xuan Zhai, Hui Chen, Lu Wang
Publikováno v:
Experimental and Molecular Medicine, Vol 53, Iss 11, Pp 1807-1818 (2021)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
The NLRC4 inflammasome, a member of the nucleotide-binding and oligomerization domain-like receptor (NLR) family, amplifies inflammation by facilitating the processing of caspase-1, interleukin (IL)–1β, and IL-18. We explored whether NLRC4 knockdo
Autor:
Jin-Kwan Lee, Si-Yeon Lee, Suhyeon Kim, Kyungrim Hwang, Heounjeong Go, Chang-Woo Lee, Seoyoon Bae
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1537-1549 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Psoriasis is one of the most common immune-mediated chronic inflammatory skin diseases. However, little is known about the molecular mechanism underlying the immunological circuits that maintain innate and adaptive immune responses in established pso
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1397-1406 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Probiotics have been defined as “Live microorganisms that when administered in adequate amounts confer a health benefit on the host”. This definition covers a wide range of applications, target populations and (combinations of) microorganisms. Im
Autor:
Jong Gil Park, Sinai Kim, Sang Hak Lee, Goo Taeg Oh, In Hyuk Jung, Na Young Ko, Se Jin Jeong, Jeong Ki Min, Min Ji Cho
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1587-1601 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease characterized by structural deterioration of the aorta caused by inflammation and oxidative stress, leading to aortic dilatation and rupture. Peroxiredoxin 2 (PRDX2), an antioxidant
Autor:
Yuxi Li, Jung-Chien Cheng, Sijia Wang, Zhen Wang, Xiaoyu Han, Yiran Li, Yingpu Sun, Yang Yan, Lanlan Fang, Ze Wu, Qiongqiong Jia
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1341-1350 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Ovarian hyperstimulation syndrome (OHSS) is one of the most life-threatening and potentially fatal complications associated with controlled ovarian hyperstimulation (COH) during in vitro fertilization (IVF) treatment. Although the pathogenesis of OHS
Autor:
Joshua Holtzman, Heedoo Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 6, Pp 887-895 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Extracellular vesicles (EVs) present numerous biomedical ways of studying disease and pathology. They function as protective packaging for the delivery of controlled concentrations of miRNAs and effector molecules, including cytokines, chemokines, ge
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 6, Pp 877-886 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Focal adhesion kinase (FAK) is an integrin-associated protein tyrosine kinase that is frequently overexpressed in advanced human cancers. Recent studies have demonstrated that aside from FAK’s catalytic activity in cancer cells, its cellular locali
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 5, Pp 815-831 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Colorectal cancer is a devastating disease with a low 5-year survival rate. Recently, many researchers have studied the mechanisms of tumor progression related to the tumor microenvironment. Here, we addressed the prognostic value of tumor-associated
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 5, Pp 781-792 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Endothelial-to-mesenchymal transition (EndMT) involves the phenotypic conversion of endothelial-to-mesenchymal cells, and was first discovered in association with embryonic heart development. EndMT can regulate various processes, such as tissue fibro
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 5, Pp 843-853 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Angiogenesis and synoviocyte hyperplasia, called ‘pannus,’ are pathologic hallmarks of rheumatoid arthritis (RA). To determine the clinical significance of angiogenic cytokines in RA, the levels of pro-angiogenic cytokines, including VEGF, placen