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Autor:
Dean E. Schraufnagel
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 3, Pp 311-317 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Ultrafine particles (PM0.1), which are present in the air in large numbers, pose a health risk. They generally enter the body through the lungs but translocate to essentially all organs. Compared to fine particles (PM2.5), they cause more pulmonary i
Autor:
Yingpu Sun, Avinash Thakur, Peter C.K. Leung, Yiran Li, Sijia Wang, Jung-Chien Cheng, Yuxi Li, Lanlan Fang, Hsun-Ming Chang, Yang Yan, Yuyin Yi
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 3, Pp 450-460 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Ovarian hyperstimulation syndrome (OHSS) is one of the most serious and iatrogenic complications that can occur during in vitro fertilization treatment. Although the pathogenesis of OHSS is not fully understood, vascular endothelial growth factor (VE
Autor:
Thi Bich Tra Cao, Quoc Quang Luu, Seung-Hyun Kim, Thuy Van Thao Nguyen, Seo-Hee Kim, Hae-Sim Park, Hoang Kim Tu Trinh
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 2, Pp 253-265 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Patients with late-onset asthma (LOA) have poor clinical outcomes. Osteopontin (OPN) is associated with airway inflammation and remodeling. To investigate the role of OPN in LOA compared to early-onset asthma (EOA), serum OPN levels were compared bet
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 1, Pp 166-175 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Age-related hearing loss (ARHL) is the progressive, bilateral loss of high-frequency hearing in elderly people. Mutations in GJB2, encoding the cochlear gap junction protein connexin26 (Cx26), are the most frequent cause of hereditary deafness; howev
Autor:
Tae Hyun Kang, Sang Taek Jung
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 11, Pp 1-9 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Monoclonal antibodies (mAbs) are one of the most widely used drug platforms for infectious diseases or cancer therapeutics because they selectively target pathogens, infectious cells, cancerous cells, and even immune cells. In this way, they mediate
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 8, Pp 1-15 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Histone deacetylase inhibitors (HDACis) are a new class of anticancer drugs confirmed to have good therapeutic effects against gastric cancer (GC) in preclinical experiments, but most HDACis are non-selective (pan-HDACis), with highly toxic side effe
Autor:
Hye Won Sim, Hanseong Kim, Bang Wool Eom, Kyeong-Man Hong, Myeong-Cherl Kook, Jungnam Joo, Young-Ho Kim, Young-Woo Kim, Yura Song, Shiv Poojan
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 8, Pp 1-10 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Circulating tumor DNA (ctDNA) has emerged as a candidate biomarker for cancer screening. However, studies on the usefulness of ctDNA for postoperative recurrence monitoring are limited. The present study monitored ctDNA in postoperative blood by empl
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 6, Pp 1-13 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia signaling pathway have been performed. The role of HIF stabilization during hypoxia has been extended from the induction of a single gene erythropoietin to the upr
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 4, Pp 1-16 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Hepatic ischemia and reperfusion injury are characterized by impaired autophagy, mitochondrial dysfunction, and subsequent compromise of cellular homeostasis following hepatic surgery or transplantation. Nobiletin, a natural flavonoid, is a beneficia
Autor:
Zebin Liao, Lei Liu, Bailong Li, Qu Hongjin, Liu Zhe, Fu Gao, Yanyong Yang, Jianming Cai, Penglin Xia, Hongran Qin
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 4, Pp 1-17 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
As a common serious complication of thoracic radiotherapy, radiation-induced pulmonary fibrosis (RIPF) severely limits radiation therapy approaches. Epithelial–mesenchymal transition (EMT) is a direct contributor to the fibroblast pool during fibro