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Publikováno v:
Experimental and Molecular Medicine, Vol 53, Iss 11, Pp 1792-1806 (2021)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
In vitro fertilization (IVF) increases the risk of tumorigenesis in offspring. The increased oxidative damage during IVF may be involved in tumor formation. However, the molecular mechanisms underlying this phenomenon remain largely unclear. Using a
Autor:
Zhipeng Meng, Minmin Zhu, Huanzhong He, Xuefang Shen, Qichao Wu, Yuqin Hu, Qing Hua, Jing Liu, Jing Wang, Xiangyuan Chen, Yanguang Su, Wanxia Xiong, Zhiyao Wang
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 10, Pp 1715-1729 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Hyperglycemia-mediated endothelial inflammation participates in the pathogenesis of cardiovascular complications in subjects with diabetes. Previous studies reported that phosphatase and tensin homolog deleted on chromosome ten (PTEN) and SET8 partic
Autor:
Hansoo Park, Sungsoon Fang, Mongjoo Jang, Jeong Hyeon Park, Youngmin Yoon, Gihyeon Kim, Myung-Giun Noh
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1574-1586 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
The gut microbiota has pivotal roles in metabolic homeostasis and modulation of the intestinal environment. Notably, the administration of Lactobacillus spp. ameliorates diet-induced obesity in humans and mice. However, the mechanisms through which L
Autor:
Jin-Kwan Lee, Si-Yeon Lee, Suhyeon Kim, Kyungrim Hwang, Heounjeong Go, Chang-Woo Lee, Seoyoon Bae
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1537-1549 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Psoriasis is one of the most common immune-mediated chronic inflammatory skin diseases. However, little is known about the molecular mechanism underlying the immunological circuits that maintain innate and adaptive immune responses in established pso
Autor:
Jinho Yang, Yoon-Keun Kim, Young Koo Jee, Sun Ha Paek, Sungmin Kym, Andrea McDowell, Tae-Seop Shin, Hyung Woo Park, Hyo Eun Moon
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1602-1613 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
The human microbiome has been recently associated with human health and disease. Brain tumors (BTs) are a particularly difficult condition to directly link to the microbiome, as microorganisms cannot generally cross the blood–brain barrier (BBB). H
Autor:
Jinho Yang, Ju Kwang Choi, Yoon Jeong Park, Da Hyeon Choi, Jae Won Chang, Bon Seok Koo, Yoon Shin Park, Ho-Ryun Won, Won Hee Lee, Jiwon Park, Chan Oh, Ju Yeon Lee, Kyeong Eun Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1564-1573 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Oral microbes have the capacity to spread throughout the gastrointestinal system and are strongly associated with multiple diseases. Given that tonsils are located between the oral cavity and the laryngopharynx at the gateway of the alimentary and re
Autor:
Yuxi Li, Jung-Chien Cheng, Sijia Wang, Zhen Wang, Xiaoyu Han, Yiran Li, Yingpu Sun, Yang Yan, Lanlan Fang, Ze Wu, Qiongqiong Jia
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1341-1350 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Ovarian hyperstimulation syndrome (OHSS) is one of the most life-threatening and potentially fatal complications associated with controlled ovarian hyperstimulation (COH) during in vitro fertilization (IVF) treatment. Although the pathogenesis of OHS
Autor:
Hyonchol Jang, Jae-Woong Min, Yura Song, Hee Yeon Kim, Eunyoung Lee, Shiv Poojan, Woong-Yang Park, Hye Won Sim, Seung-Hyun Bae, Eun-Kyung Kang, Kyeong-Man Hong, Young-Ho Kim, Yourae Hong, Hae-Ock Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 7, Pp 1102-1115 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
To elucidate the epigenetic mechanisms of drug resistance, epigenetically reprogrammed H460 cancer cells (R-H460) were established by the transient introduction of reprogramming factors. Then, the R-H460 cells were induced to differentiate by the wit
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 7, Pp 1152-1163 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Rab coupling protein (RCP) is upregulated in head and neck squamous cell carcinoma (HNSCC) and is correlated with the progression and survival of patients. However, the role of RCP in one of the aggressive types of HNSCC, oral squamous cell carcinoma
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 4, Pp 643-657 (2020)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Chromosomal instability (CIN) in cancer cells has been reported to activate the cGAS–STING innate immunity pathway via micronuclei formation, thus affecting tumor immunity and tumor progression. However, adverse effects of the cGAS/STING pathway as