Zobrazeno 41 - 50
of 111
pro vyhledávání: ''
Publikováno v:
Experimental & Molecular Medicine
Natural killer (NK) cells have gained considerable attention as promising therapeutic tools for cancer therapy due to their innate selectivity against cancer cells over normal healthy cells. With an array of receptors evolved to sense cellular altera
Publikováno v:
Experimental & Molecular Medicine
Alectinib, an inhibitor of anaplastic lymphoma kinase (ALK), was approved by the Food and Drug Administration (FDA) for the treatment of patients with ALK-positive non-small cell lung cancer (NSCLC). Here we investigated the reversal effect of alecti
Publikováno v:
Experimental & Molecular Medicine
Developmental information aids stem cell biologists in producing tissue-specific cells. Recapitulation of the developmental profile of a specific cell type in an in vitro stem cell system provides a strategy for manipulating cell-fate choice during t
Autor:
Aerin Yoon, Sukmook Lee, Taek Keun Kim, Kangseung Lee, Hee Jun Na, Chang Sik Park, Junho Chung
Publikováno v:
Experimental & Molecular Medicine
Tumor necrosis factor alpha (TNFα)-induced angiogenesis plays important roles in the progression of various diseases, including cancer, wet age-related macular degeneration, and rheumatoid arthritis. However, the relevance and role of vascular cell
Publikováno v:
Experimental & Molecular Medicine
Tumor growth is governed by the coordinated action of various types of cells that are present in the tumor environment. Fibroblasts, which constitute a major fraction of the stroma, participate actively in various signaling events and regulate tumor
Autor:
In Gyu Kim, Ji Hyeon Kim, Min Wook Lee, Kwang Pyo Kim, Jung Hoon Lee, Seung Kyun Shin, Hak Joong Kim, Sue Ah Noh, Young Hoon Son, Min Jae Lee
Publikováno v:
Experimental & Molecular Medicine
Proteasomes are the primary degradation machinery for oxidatively damaged proteins that compose a class of misfolded protein substrates. Cellular levels of reactive oxygen species increase with age and this cellular propensity is particularly harmful
Autor:
Somi Kim, Bong-Kiun Kaang
Publikováno v:
Experimental & Molecular Medicine
Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes. Among the various processes occurring at differ
Publikováno v:
Experimental & Molecular Medicine
Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell–cell communication by transferring nucleic acids and proteins to target cells and tissu
Publikováno v:
Experimental & Molecular Medicine
We sought to identify common key regulators and build a gene-metabolite network in different nonalcoholic fatty liver disease (NAFLD) phenotypes. We used a high-fat diet (HFD), a methionine-choline-deficient diet (MCDD) and streptozocin (STZ) to esta
Publikováno v:
Experimental & Molecular Medicine
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can also alter the redox balance. Thus,