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Autor:
Ji Eun Kim, Youngmi Jung
Publikováno v:
Experimental & Molecular Medicine
Although radiotherapy (RT) is used for the treatment of cancers, including liver cancer, radiation-induced liver disease (RILD) has emerged as a major limitation of RT. Radiation-induced toxicities in nontumorous liver tissues are associated with the
Autor:
Seung Yoon Park, In San Kim
Publikováno v:
Experimental & Molecular Medicine
The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end, cells undergoing apoptosis must display engulfment signals, such as 'find-me' and 'eat-me' signals. Engulfment signals are recognized by multiple types of p
Publikováno v:
Experimental & Molecular Medicine
Co-transcriptional methylations of histone H3 at lysines 4 and 36, highly conserved methyl marks from yeast to humans, have profound roles in regulation of histone acetylation. These modifications function to recruit and/or activate distinct histone
Autor:
Fredrik Y. Frejd, Kyu-Tae Kim
Publikováno v:
Experimental & Molecular Medicine
Affibody molecules can be used as tools for molecular recognition in diagnostic and therapeutic applications. There are several preclinical studies reported on diagnostic and therapeutic use of this molecular class of alternative scaffolds, and early
Publikováno v:
Experimental & Molecular Medicine
Natural killer (NK) cells have gained considerable attention as promising therapeutic tools for cancer therapy due to their innate selectivity against cancer cells over normal healthy cells. With an array of receptors evolved to sense cellular altera
Autor:
Somi Kim, Bong-Kiun Kaang
Publikováno v:
Experimental & Molecular Medicine
Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes. Among the various processes occurring at differ
Publikováno v:
Experimental & Molecular Medicine
Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell–cell communication by transferring nucleic acids and proteins to target cells and tissu
Publikováno v:
Experimental & Molecular Medicine
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can also alter the redox balance. Thus,
Autor:
Magdy M. Mahfouz, Ayman Eid
Publikováno v:
Experimental & Molecular Medicine
Molecular scissors engineered for site-specific modification of the genome hold great promise for effective functional analyses of genes, genomes and epigenomes and could improve our understanding of the molecular underpinnings of disease states and
Publikováno v:
Experimental & Molecular Medicine
Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among different anatomical depots stems from their intrinsic differences in cellular and physiological properties, including developmental origin, adipogenic and proliferativ