Zobrazeno 1 - 10
of 12
pro vyhledávání: ''
Autor:
Zhongquan Dai, Hongyu Zhang, Feng Wu, Hailong Wang, Chao Yang, Yu Li, Yinghui Li, Yongjie Chen, Kai Li, Ji Xu, Jian Chen
Publikováno v:
Experimental & Molecular Medicine
Long-term spaceflight affects numerous organ systems in the body, including metabolic dysfunction. Recently, ample evidence has demonstrated that the liver is a vulnerable organ during spaceflight. However, the changes in hepatocyte proliferation and
Autor:
Xing-Li Fu, Jun Peng, Huilin Yang, Lei Liu, Jinzhi Wang, Zhenhuan Jiang, Zhijun Ge, Yong-Fei Tan, Jiannong Jiang
Publikováno v:
Experimental & Molecular Medicine
Osteosarcoma is suggested to be caused by genetic and molecular alterations that disrupt osteoblast differentiation. Recent studies have reported that transmembrane protein 119 (TMEM119) contributes to osteoblast differentiation and bone development.
Autor:
Shuping Han, Xuehua Liu, Mengmeng Li, Jing Xu, Zhangbin Yu, Shasha Zhu, Xiaoshan Hu, Yuzhu Peng
Publikováno v:
Experimental & Molecular Medicine
MicroRNAs (miRNAs) are small, non-coding single-stranded RNAs that suppress protein expression by binding to the 3' untranslated regions of their target genes. Many studies have shown that miRNAs have important roles in congenital heart diseases (CHD
Publikováno v:
Experimental & Molecular Medicine
Sur8, a scaffold protein of the Ras pathway, interacts with Ras and Raf and modulates the Ras-extracellular signal-regulated kinase (ERK) pathway. Here we show that Sur8 is overexpressed in established human colorectal cancer (CRC) cell lines and CRC
Autor:
Seo Yeon Jin, Dong Hyung Lee, Seung-Hoon Baek, Hye Sun Lee, Sun Sik Bae, Young-Hwan Kim, Hwa Kyoung Shin, Sang Heon Song, Jung Min Ha, Sun Ja Kim, Chi Dae Kim
Publikováno v:
Experimental & Molecular Medicine
Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein endothelial cells (HUVEC
Publikováno v:
Experimental & Molecular Medicine
Neointimal proliferation after vascular injury is a key mechanism of restenosis, a major cause of percutaneous transluminal angioplasty failure and artery bypass occlusion. Emodin, an anthraquinone with multiple physiological activities, has been rep
Autor:
Young Myeong Kim, Byeong Hwa Jeon, Il Hwan Park, Hyung-Joo Kwon, Hye Mi Hwang, Kwang Lae Hoe, Sungwoo Ryoo
Publikováno v:
Experimental & Molecular Medicine
Elevated plasma concentration of native low-density lipoprotein (nLDL) is associated with vascular smooth muscle cell (VSMC) activation and cardiovascular disease. We investigated the mechanisms of superoxide generation and its contribution to pathop
Autor:
Sei-Myoung Han, Sang-Hun Han, Jeong Chan Ra, Sung Keun Kang, Hee-Woo Lee, Ye-Rin Coh, Hwa-Young Youn, Goo Jang
Publikováno v:
Experimental & Molecular Medicine
Mesenchymal stem cells (MSCs) are attractive candidates for clinical repair or regeneration of damaged tissues. Oct4 and Sox2, which are essential transcription factors for pluripotency and self-renewal, are naturally expressed in MSCs at low levels
Publikováno v:
Experimental & Molecular Medicine
Type 1 diabetes is an autoimmune disease caused by permanent destruction of insulin-producing pancreatic β cells and requires lifelong exogenous insulin therapy. Recently, islet transplantation has been developed, and although there have been signif
Publikováno v:
Experimental & Molecular Medicine
Gastric cancer overexpressing the human epidermal growth factor 2 (HER2) protein has a poor outcome, although a combination of chemotherapy and the anti-HER2 antibody trastuzumab has been approved for the treatment of advanced gastric cancer. Vascula