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Autor:
Seung Yoon Park, In San Kim
Publikováno v:
Experimental & Molecular Medicine
The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end, cells undergoing apoptosis must display engulfment signals, such as 'find-me' and 'eat-me' signals. Engulfment signals are recognized by multiple types of p
Autor:
Fredrik Y. Frejd, Kyu-Tae Kim
Publikováno v:
Experimental & Molecular Medicine
Affibody molecules can be used as tools for molecular recognition in diagnostic and therapeutic applications. There are several preclinical studies reported on diagnostic and therapeutic use of this molecular class of alternative scaffolds, and early
Publikováno v:
Experimental & Molecular Medicine
Natural killer (NK) cells have gained considerable attention as promising therapeutic tools for cancer therapy due to their innate selectivity against cancer cells over normal healthy cells. With an array of receptors evolved to sense cellular altera
Publikováno v:
Experimental & Molecular Medicine
Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell–cell communication by transferring nucleic acids and proteins to target cells and tissu
Publikováno v:
Experimental & Molecular Medicine
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can also alter the redox balance. Thus,
Publikováno v:
Experimental & Molecular Medicine
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual's health. The liver has a major role in the control of glucose homeostasis by controlling various pathways of glucose metabolism,
Autor:
Yong T.ae Kwon, Aaron Ciechanover
Publikováno v:
Experimental & Molecular Medicine
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the UPS, in w
Publikováno v:
Experimental & Molecular Medicine
Cancer cells and the immune system are closely related and thus influence each other. Although immune cells can suppress cancer cell growth, cancer cells can evade immune cell attack via immune escape mechanisms. Natural killer (NK) cells kill cancer
Autor:
Beom Seok Park, Jie-Oh Lee
Publikováno v:
Experimental & Molecular Medicine
Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria. Minute amounts of LPS released from infecting pathogens can initiate potent innate immune responses that prime the immune system against further infection.
Autor:
Connie J. Eaves, Michael R. Copley
Publikováno v:
Experimental & Molecular Medicine
Hematopoietic stem cells (HSCs) comprise a rare population of cells that can regenerate and maintain lifelong blood cell production. This functionality is achieved through their ability to undergo many divisions without activating a poised, but laten