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Autor:
Leandro J. Bertoglio, Reinaldo N. Takahashi, Ismael Galve-Roperh, Lucas Gazarini, Ana C. Vanvossen, Francisco Silveira Guimarães, Cristina A.J. Stern, Antonio Waldo Zuardi
Publikováno v:
European Neuropsychopharmacology. 25:958-965
Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the major constituents of the Cannabis sativa plant, which is frequently consumed by subjects exposed to life-threatening situations to relief their symptomatology. It is still unknown, howev
Publikováno v:
European Neuropsychopharmacology. 23:645-652
Cholecystokinin-tetrapeptide (CCK-4)-induced panic attacks are reportedly attenuated by effective treatment with antipanic antidepressants in patients with panic disorder, but in healthy volunteers such effects are not well studied. The aim of this s
Publikováno v:
European Neuropsychopharmacology. 26:S289-S290
Publikováno v:
European Neuropsychopharmacology. 20:236-244
In previous studies, acutely administered oral methylphenidate (MPD, 3 mg/kg) prior to testing improved performance on the radial arm maze in juvenile rats. In order to examine the mechanisms producing this improvement we administered MPD once prior
Publikováno v:
European Neuropsychopharmacology. 18:455-461
Current treatments for Obsessive Compulsive Disorder (OCD) rely primarily on serotonergic mechanisms. However, approximately 30% of patients do not respond to serotonin reuptake inhibitors and remain chronically ill. Given the behavioral similarities
Publikováno v:
European Neuropsychopharmacology. 18:41-47
Abolishment of anxiolytic-like effects of diazepam occurs during re-exposure to some animal tests of anxiety. We investigated the loss of anxiolytic-like effects of diazepam during Trial 2 on previously undrugged mice, namely one-trial tolerance (OTT
Publikováno v:
European Neuropsychopharmacology. 14:29-37
Since hyperventilation and shortness of breath are characteristic features of panic attacks, and since the attacks can be elicited by CO(2) inhalation, an involvement of central or peripheral chemoreceptors in the pathophysiology of panic disorder ha
Autor:
Dirk Wedekind, Uwe Bartmann, Andreas Broocks, E. Rüther, U. Hillmer-Vogel, Tim Meyer, Borwin Bandelow, G. Pekrun, M. Opitz, A. George
Publikováno v:
European Neuropsychopharmacology. 13:153-164
Blunted neuroendocrine and physiological responses to the selective 5-HT(1A) receptor agonist, ipsapirone, have been observed in patients with panic disorder and/or agoraphobia (PDA). In order to examine whether this hyporesponsiveness to ipsapirone
Publikováno v:
European Neuropsychopharmacology. 25:S566-S567
Publikováno v:
European Neuropsychopharmacology. 6:311-316
The N-methyl-d-aspartate (NMDA) receptor polyamine site antagonist, ifenprodil, had no effect on spontaneous alternation or locomotor activity in the Y-maze when given alone. The NMDA receptor/ion channel blocker, dizocilpine, induced a deficit in sp