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Publikováno v:
European Journal of Neuroscience. 54:6355-6373
Prostaglandin E2 (PGE2) is a bioactive signalling molecule metabolized from the phospholipid membranes by the enzymatic activity of cycloxygenase-2 (COX-2). In the developing brain, COX-2 constitutively regulates the production of PGE2, which is impo
Autor:
Marco A. M. Prado, Vania F. Prado, Monica S. Guzman, Helena Janickova, Mohammed A. Al-Onaizi, Ornela Kljakic, Kevin S. Chen
Publikováno v:
European Journal of Neuroscience. 54:6075-6092
Disruptions in social behaviour are prevalent in many neuropsychiatric disorders such as schizophrenia, bipolar disorder and autism spectrum disorders. However, the underlying neurochemical regulation of social behaviour is still not well understood.
Autor:
L. Ray, Ian B. Hickie, Stuart Fogel, Joanne S. Carpenter, Rébecca Robillard, Khaoula Louati, Meggan Porteous
Publikováno v:
European Journal of Neuroscience. 54:5112-5119
Sleep fragmentation and reductions in sleep spindles have been observed in individuals with depression. Sleep spindles are known to play a protective role for sleep, and there are indications that melatonin agents can enhance spindles in healthy peop
Autor:
Christina J. Perry, Damien Battista, Diana Sketriene, Priya Sumithran, Robyn M Brown, Andrew J Lawrence
Publikováno v:
European Journal of Neuroscience. 54:4877-4887
Compulsive forms of eating displayed by some obese individuals share similarities with compulsive drug taking behaviour, a hallmark feature of substance use disorder. This raises the possibility that drug addiction treatments may show utility in the
Publikováno v:
European Journal of Neuroscience. 53:3743-3767
Several useful animal models for parkinsonism have been developed so far. Haloperidol-induced catalepsy is often used as a rodent model for the study of motor impairments observed in Parkinson's disease and related disorders and for the screening of
Autor:
Maxime Assous
Publikováno v:
Eur J Neurosci
The critical role of acetylcholine (ACh) in the basal ganglia is evident from the effect of cholinergic agents in patients suffering from several related neurological disorders, such as Parkinson's disease, Tourette syndrome, or dystonia. The striatu
Publikováno v:
European Journal of Neuroscience. 55:2684-2698
Failures to cognitively downregulate negative emotions are a crucial risk factor for mental disorders. Previous studies provide evidence for a stress-induced improvement of cognitive emotion regulation possibly mediated via glucocorticoid actions. Co
Publikováno v:
European Journal of Neuroscience. 55:2108-2121
Early life stress (ELS) programs hypothalamus-pituitary-adrenal (HPA) axis activity and affects synaptic plasticity and cognitive performance in adults; however, the effects of ELS during the temporal window of vulnerability are poorly understood. Th
Publikováno v:
European Journal of Neuroscience. 53:2541-2552
Chronic hyperglycemia induces activation of the polyol-sorbitol pathway, which is a major contributor to microvascular complications like stroke. The current study was designed to elucidate the therapeutic role of α-glucose inhibitor in chronic hype
Publikováno v:
Hales, C A, Bartlett, J M, Arban, R, Hengerer, B & Robinson, E S 2021, ' Effects of pro-depressant and immunomodulatory drugs on biases in decision-making in the rat judgement bias task ', European Journal of Neuroscience . https://doi.org/10.1111/ejn.15127
Studies in human and non‐human species suggest that decision‐making behaviour can be biased by affective state, also termed an affective bias. To study these behaviours in non‐human species, judgement bias tasks have been developed. Animals are