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Publikováno v:
Development. 149
A long-standing biological question is how DNA cis-regulatory elements shape transcriptional patterns during metazoan development. The use of reporter constructs, cell culture and computational modeling has made enormous contributions to understandin
Autor:
Justin Crocker, Albert Tsai
Publikováno v:
Development. 149
An embryo experiences progressively complex spatial and temporal patterns of gene expression that guide the morphogenesis of its body plan as it matures. Using super-resolution fluorescence microscopy in Drosophila melanogaster embryos, we observed a
Publikováno v:
Development. 148
The shaping of tissues and organs in many animals relies on interactions between the epithelial cell layer and its underlying mesoderm-derived tissues. Inductive signals, such as receptor tyrosine kinase (RTK) signaling emanating from mesoderm, act o
Autor:
David Cobrinik, Angela Ferrario, Jennifer G. Aparicio, Sumitha Prameela Bharathan, G. Esteban Fernandez, Brendan H. Grubbs, Matthew E. Thornton, Carolyn Marks, Kayla Stepanian, Mark W. Reid, Justin S. Kim, Chloe Hutchens, Narine Harutyunyan, Aaron Nagiel
Publikováno v:
Development
The development of the first synapse of the visual system between photoreceptors and bipolar cells in the outer plexiform layer (OPL) of the human retina is crucial for visual processing but poorly understood. By studying the maturation state and spa
Publikováno v:
Development
Pericytes reside in capillary beds where they share a basement membrane with endothelial cells and regulate their function. However, little is known about embryonic pericyte development, in part, due to lack of specific molecular markers and genetic
Autor:
Paul M. Kulesa, Allison R. Scott, Rebecca McLennan, Jessica M. Teddy, Jennifer C. Kasemeier-Kulesa, Madelaine Gogol, Jason A. Morrison
Publikováno v:
Development. 148
The dynamics of multipotent neural crest cell differentiation and invasion as cells travel throughout the vertebrate embryo remain unclear. Here, we preserve spatial information to derive the transcriptional states of migrating neural crest cells and
Autor:
Tsuku Mogami
Publikováno v:
Development. 148
Autor:
Lichao Xu, Hanzhe Ye, Yan Zhou, Kuan Tian, Si Li, Ying Liu, Xiaojiao Hua, Junbao Wang, Andi Wang, Bo Zhang, Kun Wang, Dawei Huo, Xudong Wu, Tao Zeng, Qing-Feng Wu, Chen Zhao, Yue Zheng
Publikováno v:
Development. 148
The production and expansion of intermediate progenitors (IPs) are essential for neocortical neurogenesis during development and over evolution. Here, we have characterized an epigenetic circuit that precisely controls neurogenic programs, particular
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The acrosome is a cap-shaped, Golgi-derived membranous organelle that is located over the anterior of the sperm nucleus and highly conserved throughout evolution. Although morphological changes during acrosome biogenesis in spermatogenesis have been
Publikováno v:
Development. 149
B cell participation in early embryo/fetal development and the underlying molecular pathways have not been explored. To understand whether maternal B cell absence or impaired signaling interferes with placental and fetal growth, we paired CD19-defici