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pro vyhledávání: ''
Autor:
Md. Shenuarin Bhuiyan, A. Wayne Orr, Xiuping Yu, Nicholas E. Goeders, Judy A. King, James G. Traylor, Paari Dominic, Brandon Hartman, Karen Y. Stokes, Connie L. Arnold, Sadia Nitu, Richa Aishwarya, Mohammad Alfrad Nobel Bhuiyan, Shafiul Alam, Mahboob Morshed, Manikandan Panchatcharam, Gopi K. Kolluru, Christopher G. Kevil, Sunitha Chandran, Matthew D. Woolard, Sumitra Miriyala, Chowdhury S. Abdullah, Naznin Sultana Remex
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-20 (2020)
Communications Biology
Communications Biology
Methamphetamine-associated cardiomyopathy is the leading cause of death linked with illicit drug use. Here we show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy and defined the molecular mechanisms using autopsy s
Autor:
Maria Celeste Varela, Roberto R. Rosato, Matthew Ojeda Saavedra, Agustina Taglialegna, James J. Davis, Melanie Roch, Scott Wesley Long, Adriana E. Rosato, Rafael E Hernandez, Lucas R. Hoffman, Warren E. Rose
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology
Communications Biology
Chronic airways infection with methicillin-resistant Staphylococcus aureus (MRSA) is associated with worse respiratory disease cystic fibrosis (CF) patients. Ceftaroline is a cephalosporin that inhibits the penicillin-binding protein (PBP2a) uniquely
Autor:
Ryul Kim, Sung Soo Yoon, Keonyong Lee, Nam Hoon Kwon, Yoosik Kim, Sunghoon Kim, Youngil Koh, Namseok Lee, Min A. Kim, Daeyoon Kim, Seulki Song, Dongchan Kim, Jayoung Ku
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications biology, vol 3, iss 1
Communications Biology
Communications biology, vol 3, iss 1
Aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a non-enzymatic component required for the multi-tRNA synthetase complex. While exon 2 skipping alternatively spliced variant of AIMP2 (AIMP2-DX2) compromises AIMP2 activity a
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology
Communications Biology
Traditional influenza vaccines primarily induce a narrow antibody response that offers no protection against heterosubtypic infections. Murine studies have shown that T cells can protect against a broad range of influenza strains. However, ferrets ar
Autor:
Nduka Enemchukwu, James T. Handa, Guogang Zhang, Megan Shen, Qing Yan, Longhou Fang, Lingping Zhu, Mackenzie Parker, Yingbin Fu
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Communications Biology
Communications Biology
Many patients of choroidal neovascularization (CNV) are unresponsive to the current anti-VEGF treatment. The mechanisms for anti-VEGF resistance are poorly understood. We explore the unique property of the apolipoprotein A-I (apoA-I) binding protein
Autor:
Vincent Vuaroqueaux, Isabella H. Wulur, Swee-Seong Wong, Manuel Landesfeind, Greg Donoho, Kerstin Klingner, Steven M. Bray, Han-Kwang Yang, Peter Bronsert, Anne-Lise Peille, Amit Aggarwal, Seong-Ho Kong, Woo Ho Kim, Bruno Zeitouni, Jason C. Ting, Christoph Reinhard, Nina Zanella, Heinz-Herbert Fiebig, Hyuk-Joon Lee
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology
Communications Biology
Patient-derived xenografts (PDX) have emerged as an important translational research tool for understanding tumor biology and enabling drug efficacy testing. They are established by transfer of patient tumor into immune compromised mice with the inte
Autor:
Jan Van Zundert, Elizaveta E Elgaeva, Pradeep Suri, Alexandra S. Shadrina, Yakov A. Tsepilov, Sodbo Zh Sharapov, Yurii S. Aulchenko, Frances M K Williams, Maxim B. Freidin, Lennart С Karssen
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications Biology, 3(1):329. Nature Publishing Group
Communications Biology
Communications Biology, 3(1):329. Nature Publishing Group
Chronic musculoskeletal pain affects all aspects of human life. However, mechanisms of its genetic control remain poorly understood. Genetic studies of pain are complicated by the high complexity and heterogeneity of pain phenotypes. Here, we apply p
Autor:
D. Kacy Cullen, Halimulati Kaisaier, Zarina S. Ali, Kevin D. Browne, Foteini Mourkioti, Melanie C Hilman, Franco A Laimo, Carlos A. Aguilar, Suradip Das, Joseph C. Maggiore
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology
Communications Biology
Volumetric muscle loss (VML) is the traumatic or surgical loss of skeletal muscle beyond the inherent regenerative capacity of the body, generally leading to severe functional deficit. Formation of appropriate somato-motor innervations remains one of
Autor:
Anabel Bergeron, Vanessa Garcia, Rozanne Arulanandam, Fanny Tzelepis, Jean-Simon Diallo, Harsimrat Kaur Birdi, Anne Landry, Andrew Chen, Anna Jirovec, Oliver Varette, Keara Sutherland, Mohammed Selman, Zaid Taha, Nouf Alluqmani, Elizabeth Macdonald, Barbara C. Vanderhyden
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology
Communications Biology
We have demonstrated that microtubule destabilizing agents (MDAs) can sensitize tumors to oncolytic vesicular stomatitis virus (VSVΔ51) in various preclinical models of cancer. The clinically approved T-DM1 (Kadcyla®) is an antibody-drug conjugate
Autor:
Pladsen, A.V., Nilsen, G., Rueda, O.M., Aure, M.R., Borgan, Ø., Liestøl, K., Vitelli, V., Frigessi, A., Langerød, A., Mathelier, A., Bathen, T.F., Borgen, E., Børresen-Dale, A.-L., Engebråten, O., Fritzman, B., Garred, Ø., Geisler, J., Geitvik, G.A., Hofvind, S., Kristensen, V., Kåresen, R., Lingjærde, O.C., Mælandsmo, G.M., Naume, B., Russnes, H.G., Sahlberg, K.K., Sauer, T., Skjerven, H.K., Schlichting, E., Sørlie, T., Wedge, D.C., Van Loo, P., Caldas, C.
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-9 (2020)
Communications Biology
Pladsen, A V, Nilsen, G, Rueda, O M, Aure, M R, Borgan, Ø, Liestøl, K, Vitelli, V, Frigessi, A, Langerød, A, Mathelier, A, Bathen, T F, Borgen, E, Børresen-Dale, A-L, Engebråten, O, Fritzman, B, Garred, Ø, Geisler, J, Geitvik, G A, Hofvind, S, Kristensen, V, Kåresen, R, Langerød, A, Lingjærde, O C, Mælandsmo, G M, Naume, B, Russnes, H G, Sahlberg, K K, Sauer, T, Skjerven, H K, Schlichting, E, Sørlie, T, Engebråten, O, Kristensen, V, Wedge, D C, Van Loo, P, Caldas, C, Børresen-Dale, A-L, Russnes, H G & Lingjærde, O C 2020, ' DNA copy number motifs are strong and independent predictors of survival in breast cancer ', Communications Biology . https://doi.org/10.1038/s42003-020-0884-6
Communications Biology
Pladsen, A V, Nilsen, G, Rueda, O M, Aure, M R, Borgan, Ø, Liestøl, K, Vitelli, V, Frigessi, A, Langerød, A, Mathelier, A, Bathen, T F, Borgen, E, Børresen-Dale, A-L, Engebråten, O, Fritzman, B, Garred, Ø, Geisler, J, Geitvik, G A, Hofvind, S, Kristensen, V, Kåresen, R, Langerød, A, Lingjærde, O C, Mælandsmo, G M, Naume, B, Russnes, H G, Sahlberg, K K, Sauer, T, Skjerven, H K, Schlichting, E, Sørlie, T, Engebråten, O, Kristensen, V, Wedge, D C, Van Loo, P, Caldas, C, Børresen-Dale, A-L, Russnes, H G & Lingjærde, O C 2020, ' DNA copy number motifs are strong and independent predictors of survival in breast cancer ', Communications Biology . https://doi.org/10.1038/s42003-020-0884-6
Somatic copy number alterations are a frequent sign of genome instability in cancer. A precise characterization of the genome architecture would reveal underlying instability mechanisms and provide an instrument for outcome prediction and treatment g